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Search Result

Search Results for " copd "

Targets

Others Antibacterial

72

Compounds

4

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1532 Pidotimod Others , Antibacterial
Pidotimod is a synthetic dipeptide with immunomodulatory properties.
T2320 Indacaterol Adrenergic Receptor
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.
T25376 Ensifentrine Ensifentrina,Ensifentrinum PDE
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...
T9448 IL-17A inhibitor 1 IL Receptor
IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM.
T9499 Icenticaftor QBW251 CFTR
Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.
T15430 GSK2256294A GSK 2256294 Others , Epoxide Hydrolase
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.
T30258 AZD-4818 CCR1 antagonist CCR
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
T4503 Talniflumate Somalgen Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T22245 Arformoterol Tartrate (R,R)-Formoterol tartrate Adrenergic Receptor
Arformoterol Tartrate ((R,R)-Formoterol tartrate) is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity[2].
T6445 Cilomilast SB-207499,Ariflo PDE
Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.
T0794 Mepenzolate Bromide Colibantil,Cantil,Cantilaque AChR
Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions.
T1239 Indacaterol maleate QAB149 Adrenergic Receptor
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
T5159 Olodaterol hydrochloride BI-1744 HCl,BI 1744 hydrochloride Adrenergic Receptor
Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors...
T34387 Ronomilast ELB353,ELB 353,ELB-353,Elbimilast
Ronomilast(Elbimilast, ELB 353) is a PDE4 inhibitor for chronic inflammatory disease. Ronomilast is developed to treat chronic obstructive pulmonary disease (COPD).
T33386 Milveterol HCl Milveterol,GSK-159797,GSK 159797,GSK159797 Adrenergic Receptor
Milveterol HCl is a long-acting β(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD).
T31207 GSK233705 Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B AChR
GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans.
T30232 AWD 12-281 GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470 PDE
AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory and bronchodilator activity used in the study of chronic obstructive pulmonary disease (COPD).
T83168 Aderamastat FP-025 MMP
Aderamastat (FP-025) is an orally active inhibitor of matrix metalloproteinase 12 (MMP-12), utilized in the research of conditions such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis [1].
T13106 TD-5471 hydrochloride Adrenergic Receptor
TD-5471 hydrochloride is a selective and potent long-acting human β2-adrenergic receptor agonist for the treatment of chronic obstructive pulmonary disease (COPD).
T33941 PF-03635659 PF03635659,PF 03635659 AChR
PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD).
T76910 Astegolimab RG 6149,MSTT 1041A Interleukin
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe ast...
T6505 Formoterol fumarate Formoterol Hemifumarate,NSC 299587,Eformoterol Hemifumarate,CGP 25827A,Eformoterol,YM 08316 Adrenergic Receptor
Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.
T70047 Bedoradrine Bedoradrine free base Adrenergic Receptor
Bedoradrine free base is a novel, highly selective β2-adrenoceptor agonist for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
T72031 BI 1015550 PDE
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo...
T39719 Nrf2 activator-1 Nrf2 activator-1 Nrf2
Nrf2 activator-1 is a potent activator of NF-E2-related factor 2 (Nrf2).Nrf2 activator-1 can be used to study COPD and other respiratory diseases including asthma, acute lung injury (ALI), acute respiratory distress synd...
T72918 JNJ-49095397 RV568
JNJ-49095397 (RV568), an inhaled narrow-spectrum kinase inhibitor (NSKI), targets the α and γ isoforms of p38 MAPK and the SRC kinase family, particularly haematopoietic kinase (HCK). Demonstrating potent anti-inflammato...
T60196 IHMT-PI3Kδ-372 S-isomer PI3K
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ...
T6653 Salmeterol Xinafoate Salmetedur,GR 33343X xinafoate,Arial HIV Protease , Adrenergic Receptor
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptom...
T77601 (2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid GPR
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con...
T1179 Tiotropium bromide Tiopropium,BA679 BR AChR
Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a...
T6707 Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR AChR
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a...
T6547 Ipratropium Bromide Sch 1000,Itrop,Atrovent AChR
Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
T2555 Aclidinium bromide LAS 34273,LAS-W 330 AChR
Aclidinium bromide (LAS-W 330) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing li...
T1139 Salbutamol Albuterol,AH-3365 Adrenergic Receptor
Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol ...
T27290 Etamiphylline Camsylate R 3588,Etamiphylline Camsilate,Milliphylline,Soluphyline,R-3588,R3588
Etamiphylline Camsylate is used for the treatment of chronic obstructive pulmonary disease (COPD).
T28519 Reproterol hydrochloride D 1959,D1959,D-1959,W-2946M,W 2946M
Reproterol hydrochloride, a β2 adrenoreceptor agonist, is used to treat asthma and chronic obstructive pulmonary disease (COPD).
TP2406 Seretide Adoair,Advair,Fluticasone/Salmeterol
Seretide, a combination of fluticasone and salmeterol, controls symptoms of asthma and chronic obstructive pulmonary disease (COPD).
T20829 Pivampicillin
Pivampicillin, a pivalate ester analog of Ampicillin, is used to treat chronic obstructive pulmonary disease (COPD) in children and young adults.
T30265 Navafenterol saccharinate AZD8871 saccharinate,LAS-191351 saccharinate,LAS191351 saccharinate,AZD-8871 saccharinate
AZD-8871 saccharinate is a dual-acting bronchodilator which may be useful in the treatment of Chronic Obstructive Pulmonary Disease (COPD).
T68240 AZD-9819
AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD).
T16509 PF-610355 Others
PF-610355 is a long-acting inhaled β2-adrenoreceptor agonist (EC50: 0.26 nM). PF-610355 has the potential for the study of asthma and COPD.
T30264 Navafenterol AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351
AZD-8871 can present a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]).
T60071 PF 00356231 MMP
PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).
T38944 Tetomilast OPC-6535,Tetomilast
Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).
T28878 Sul-121 HCl Sul-121 Hydrochloride
Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidati...
T13277 Valategrast R-411 free base Others
Valategrast is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, with the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.
T25030 Albuterol stearate
Albuterol stearate is a salt of Albuterol. Albuterol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 r...
T71240 AS 703026
AS 703026 has been shown to inhibit LPS-induced TNFα production in macrophages/monocytes as well as protect from LPS-induced endotoxin shock. AS 703026 may be useful as an anti-inflammatory therapy for COPD patients.
T79538 PDE4-IN-13
PDE4-IN-13 is a phosphodiesterase 4 (PDE4) inhibitor exhibiting anti-inflammatory and antioxidant activities, with an half maximal inhibitory concentration (IC50) value of 1.56 μM. It is used in the research of chronic o...
T26628 Andolast CR2039,CR-2039,CR 2039
Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesi...

Compounds

Pidotimod
T1532
Synonym:
Target: Others, Antibacterial
Indacaterol
T2320
Synonym:
Target: Adrenergic Receptor
Ensifentrine
T25376
Synonym: Ensifentrina,Ensifentrinum
Target: PDE
IL-17A inhibitor 1
T9448
Synonym:
Target: IL Receptor
Icenticaftor
T9499
Synonym: QBW251
Target: CFTR
GSK2256294A
T15430
Synonym: GSK 2256294
Target: Others, Epoxide Hydrolase
AZD-4818
T30258
Synonym: CCR1 antagonist
Target: CCR
Talniflumate
T4503
Synonym: Somalgen
Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger
Arformoterol Tartrate
T22245
Synonym: (R,R)-Formoterol tartrate
Target: Adrenergic Receptor
Cilomilast
T6445
Synonym: SB-207499,Ariflo
Target: PDE
Mepenzolate Bromide
T0794
Synonym: Colibantil,Cantil,Cantilaque
Target: AChR
Indacaterol maleate
T1239
Synonym: QAB149
Target: Adrenergic Receptor
Olodaterol hydrochloride
T5159
Synonym: BI-1744 HCl,BI 1744 hydrochloride
Target: Adrenergic Receptor
Ronomilast
T34387
Synonym: ELB353,ELB 353,ELB-353,Elbimilast
Target:
Milveterol HCl
T33386
Synonym: Milveterol,GSK-159797,GSK 159797,GSK159797
Target: Adrenergic Receptor
GSK233705
T31207
Synonym: Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B
Target: AChR
AWD 12-281
T30232
Synonym: GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470
Target: PDE
Aderamastat
T83168
Synonym: FP-025
Target: MMP
TD-5471 hydrochloride
T13106
Synonym:
Target: Adrenergic Receptor
PF-03635659
T33941
Synonym: PF03635659,PF 03635659
Target: AChR
Astegolimab
T76910
Synonym: RG 6149,MSTT 1041A
Target: Interleukin
Formoterol fumarate
T6505
Synonym: Formoterol Hemifumarate,NSC 299587,Eformoterol Hemifumarate,CGP 25827A,Eformoterol,YM 08316
Target: Adrenergic Receptor
Bedoradrine
T70047
Synonym: Bedoradrine free base
Target: Adrenergic Receptor
BI 1015550
T72031
Synonym:
Target: PDE
Nrf2 activator-1
T39719
Synonym: Nrf2 activator-1
Target: Nrf2
JNJ-49095397
T72918
Synonym: RV568
Target:
IHMT-PI3Kδ-372 S-isomer
T60196
Synonym:
Target: PI3K
Salmeterol Xinafoate
T6653
Synonym: Salmetedur,GR 33343X xinafoate,Arial
Target: HIV Protease, Adrenergic Receptor
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid
T77601
Synonym:
Target: GPR
Tiotropium bromide
T1179
Synonym: Tiopropium,BA679 BR
Target: AChR
Tiotropium Bromide hydrate
T6707
Synonym: BA-679 BR hydrate,BA 679BR
Target: AChR
Ipratropium Bromide
T6547
Synonym: Sch 1000,Itrop,Atrovent
Target: AChR
Aclidinium bromide
T2555
Synonym: LAS 34273,LAS-W 330
Target: AChR
Salbutamol
T1139
Synonym: Albuterol,AH-3365
Target: Adrenergic Receptor
Etamiphylline Camsylate
T27290
Synonym: R 3588,Etamiphylline Camsilate,Milliphylline,Soluphyline,R-3588,R3588
Target:
Reproterol hydrochloride
T28519
Synonym: D 1959,D1959,D-1959,W-2946M,W 2946M
Target:
Seretide
TP2406
Synonym: Adoair,Advair,Fluticasone/Salmeterol
Target:
Pivampicillin
T20829
Synonym:
Target:
Navafenterol saccharinate
T30265
Synonym: AZD8871 saccharinate,LAS-191351 saccharinate,LAS191351 saccharinate,AZD-8871 saccharinate
Target:
AZD-9819
T68240
Synonym:
Target:
PF-610355
T16509
Synonym:
Target: Others
Navafenterol
T30264
Synonym: AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351
Target:
PF 00356231
T60071
Synonym:
Target: MMP
Tetomilast
T38944
Synonym: OPC-6535,Tetomilast
Target:
Sul-121 HCl
T28878
Synonym: Sul-121 Hydrochloride
Target:
Valategrast
T13277
Synonym: R-411 free base
Target: Others
Albuterol stearate
T25030
Synonym:
Target:
AS 703026
T71240
Synonym:
Target:
PDE4-IN-13
T79538
Synonym:
Target:
Andolast
T26628
Synonym: CR2039,CR-2039,CR 2039
Target:
1 2
Cat No. Product Name Synonyms Targets
TN1355 Acanthoside B Immunology/Inflammation related
Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation.
T0480 Doxofylline Doxophylline PDE , Adenosine Receptor
Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with s...
T4120 N-Methylsarcosine N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,DMG Endogenous Metabolite
N-Methylsarcosine (Dimethylglycine) is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of p...
T5S0313 Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside Liquiritin apioside Others , TNF
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as p...

Natural Products

Acanthoside B
TN1355
Synonym:
Target: Immunology/Inflammation related
Doxofylline
T0480
Synonym: Doxophylline
Target: PDE, Adenosine Receptor
N-Methylsarcosine
T4120
Synonym: N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,DMG
Target: Endogenous Metabolite
Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside
T5S0313
Synonym: Liquiritin apioside
Target: Others, TNF

Recombinant Proteins

Species：
Human (4)
Mouse (1)
Expression System：
Human Cells (4)
HEK293 (1)
Tag：
C-6His (2)
C-6His-Avi (1)
C-Fc (1)
His (1)
Cat No. Product Name Species Expression System
TMPY-04321 CHRNA5 Protein, Human, Recombinant (His) Human HEK293
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in ...
TMPJ-00078 IL-17C Protein, Human, Recombinant (His) Human Human Cells
Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. Thes...
TMPJ-00077 IL -17C Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. Thes...
TMPJ-01208 IL-17RE Protein, Mouse, Recombinant (His) Mouse Human Cells
Interleukin 17 Receptor E (IL 17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL 17 receptors. IL 17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma ...
TMPJ-01230 IL-17RE Protein, Human, Recombinant (hFc) Human Human Cells
Interleukin 17 Receptor E (IL 17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL 17 receptors. IL 17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma ...
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