T5996 |
CB1-IN-1
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DBPR211,1-(2,4-二氯苯基)-N-1-哌啶基-4-[[(1-吡咯烷基磺酰基)氨基]甲基]-5-[5-[2-[4-(三氟甲基)苯基]乙炔基]-2-噻吩基]-1H-吡唑-3-甲酰胺 |
Cannabinoid Receptor
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CB1-IN-1 是新型的外周大麻素-1受体 (CB1R) 拮抗剂,作用于CB1R (EC50 = 3 nM) 和 CB2R 的Ki 分别为0.3 nM 和 21 nM。 |
T30252 |
AZD1940
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AZD 1940,UNII-0J0035E9FT,AZD-1940 |
Cannabinoid Receptor
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AZD1940是一种高亲和力的大麻素CB(1)/CB(2)受体激动剂,具有口服活性,应用于口面疼痛的研究。 |
T10697 |
CB2R-IN-1
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Others
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CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM). |
T5S1897 |
Linderalactone
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JAK
,
Apoptosis
,
Others
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Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯,通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。 |
T8425 |
Linoleoyl Ethanolamide
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|
TRP/TRPV Channel
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Linoleoyl ethanolamide 是脂肪酸乙醇酰胺。它可弱结合 CB1 和 CB2 受体,并分别抑制[3H]CP-55,940的结合,Ki 分别为 10 和 25μM。它在引起小鼠过氧化氢酶方面的效力是 anandamide 的... |
T4654 |
(±)-Ibipinabant
|
(±)-SLV319,SLV319,(±)-BMS6462 |
Cannabinoid Receptor
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|
SLV319 是一种有效选择性的大麻素-1 (CB-1) 受体拮抗剂,IC50=22 nM。(±)-SLV319 是 SLV319的消旋体。 |
T36520 |
COR659
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Cannabinoid Receptor
,
GABA Receptor
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COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。 |
T23099 |
O-2050
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Others
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O-2050 是一种高亲和力的大麻素CB1受体拮抗剂,Ki 为 2.5 nM。O-2050 抑制大麻素 CB2受体,Ki 为 0.2 nM。O-2050 减少了小鼠的食物摄入量,并且引起小鼠运动。 |
T28235 |
OMDM169
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OMDM-169,OMDM 169 |
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OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity vi... |
T61336 |
Numidargistat dihydrochloride
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|
|
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Numidargistat dihydrochloride (CB-1158) is a highly potent and orally active chemical compound that effectively inhibits... |
T38028 |
(R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide
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|
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N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Doc... |
T39309 |
Telaglenastat hydrochloride
|
CB-839 hydrochloride |
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Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1... |
T38029 |
(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide
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|
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N-Acyl ethanolamines have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ... |
T38138 |
Arachidonoyl 2'-Chloroethylamide
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Arachidonoyl 2'-Chloroethylamide,2'-chloro-AEA,ACEA |
|
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Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1... |
T38204 |
GAT229
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GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator ... |