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Cat No. | Product Name | Synonyms | Targets |
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T80131 | C5a Anaphylatoxin (human) | Complement System | |
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses, including allergic asthma [1] [2]. | |||
T80265 | C5a Receptor agonist, mouse, human | Complement System | |
C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as an agonist for the C5a receptor. This peptide plays a role in mediat... | |||
T9915 | Eculizumab | Complement System | |
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5 | |||
T17250 | W-54011 | ROS , Complement System | |
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g... | |||
T82797 | C5aR1 antagonist peptide | ||
C5aR1 antagonist peptide, a biologically active linear peptide originating from the C-terminus of the chemokine complement fragment 5 anaphylatoxin (C5a), inhibits C5a binding and activity at human and rat C5a receptors.... | |||
T73261 | C5aR-IN-1 | ||
C5aR-IN-1 is a potent inhibitor of C5aR . Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-1 has the potential for the research of inflammation di... | |||
T73262 | C5aR-IN-3 | ||
C5aR-IN-3 is a potent inhibitor of C5aR . Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-3 has the potential for the research of inflammation di... | |||
T64200 | C5aR-IN-2 | ||
C5aR-IN-2 is a potent inhibitor of C5aR. C5aR-IN-2 has shown potential for the study of inflammatory diseases. | |||
TP1834 | MUC5AC motif peptide | ||
MUC5AC motif peptide is a 16-amino acid fragment of mucin 5. | |||
T60161 | CP-289 | Complement System | |
CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM. | |||
T12506L1 | PMX 205 acetate(514814-49-4 free base) | Complement System | |
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88). | |||
T60151 | CP-447697 | Complement System | |
CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation. | |||
T8223 | Avacopan | CCX168 | Complement System |
Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model o... | |||
TP2334 | PMX 53 acetate(219639-75-5 free base) | Complement System | |
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an ag... | |||
T9316 | JR14a | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride | Complement System |
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. | |||
T12506L | PMX 205 | Others | |
PMX 205 is an effective complement antagonist of the C5a receptor. | |||
T73710 | PMX 205 Trifluoroacetate | ||
PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist. | |||
T76913 | Avdoralimab | ||
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases an... | |||
T12506 | PMX 205 Trifluoroacetate (514814-49-4 free base) | PMX 205 Trifluoroacetate | Others |
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor. | |||
T76958 | Vilobelimab | ||
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti- C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhi... | |||
T83669 | PMX-53 TFA | AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53 | |
PMX-53, a macrocyclic complement 5a (C5a) peptidomimetic and C5a receptor antagonist (IC50 = 0.3 µM), effectively inhibits the C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes... | |||
T35836 | PMX-205 (trifluoroacetate salt) | ||
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3... | |||
T28429 | PMX-53 | PMX53,PMX 53 | |
PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR(CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-... | |||
T74551 | Avacincaptad pegol sodium | ||
Avacincaptad pegol (ARC1905) is is an anti-C5 RNA aptamer that inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. Avacincaptad pegol is being used for the study of age-related macular degeneration (AMD). | |||
T74552 | Non-PEGylated/naked ARC1905 | ||
Non-PEGylated/naked ARC1905 is is an anti-C5 RNA aptamer without PEG conjugation. Non-PEGylated/naked ARC1905 inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. Non-PEGylated/naked ARC1905 is being used ... | |||
T77107 | Olendalizumab | ||
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K i =60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be us... | |||
T74650 | JPE-1375 | ||
JPE-1375 is a complement C5a receptor 1 ( C5aR1 ) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization ( EC 50 =6.9 µM) and reduces TNF levels ( EC 50 =4.5 µM) in mice. JPE-1375 can be used ... | |||
T79376 | SARS-CoV-2 3CLpro-IN-19 | SARS-CoV | |
SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of 0.7 μM. It demonstrates broad-spectrum efficacy against inf... |
Cat No. | Product Name | Species | Expression System |
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TMPY-00653 | Complement C5 Protein, Human, Recombinant (Complement C5a) | Human | E. coli |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-04902 | Complement C5a Protein, Mouse, Recombinant | Mouse | E. coli |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-05057 | Complement C5 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPH-03107 | Complement C5a Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | Yeast |
Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT3 and more rarely with PMT2 to transfer mannose from Dol-P-mannose to Ser or Thr ... | |||
TMPY-05459 | Complement C5a Protein, Mouse, Recombinant, Biotinylated | Mouse | E. coli |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-06814 | Complement C5 Protein, Human, Recombinant (Flag) | Human | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPK-01205 | MDL-1/CLEC5A Protein, Human, Recombinant (hFc) | Human | HEK293 |
In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, i... | |||
TMPY-03760 | CLEC5A Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesio... | |||
TMPK-01218 | MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, i... | |||
TMPY-00999 | UNC5A Protein, Human, Recombinant (His) | Human | HEK293 |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu... | |||
TMPY-00648 | UNC5A Protein, Human, Recombinant (hFc) | Human | HEK293 |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu... | |||
TMPH-01023 | C5AR1 Protein, Human, Recombinant (Cell-Free, His) | Human | in vitro E. coli expression system |
TMPH-02121 | SLC5A5 Protein, Human, Recombinant (B2M & His) | Human | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPY-03872 | CLEC5A Protein, Rat, Recombinant (His) | Rat | HEK293 |
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesio... | |||
TMPY-03928 | CLEC5A Protein, Rhesus, Recombinant (mFc) | Rhesus | HEK293 |
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesio... | |||
TMPH-03074 | UBC5A Protein, Japonica rice, Recombinant (His & Myc) | Rice | E. coli |
TMPH-01022 | C5AR1 Protein-VLP, Human, Recombinant (His) | Human | HEK293 |
TMPH-02119 | SLC5A2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activi... | |||
TMPH-02032 | GPRC5A Protein, Human, Recombinant (GST) | Human | E. coli |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator... | |||
TMPH-02120 | SLC5A5 Protein, Human, Recombinant (His) | Human | E. coli |
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l... | |||
TMPY-06137 | Complement C5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPH-03529 | Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) | Staphylococcus aureus | Yeast |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leu... | |||
TMPH-03528 | Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc) | Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leu... | |||
TMPY-06538 | Complement C5 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPH-03184 | P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc) | Pseudomonas phage phi6 | E. coli |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leu... | |||
TMPH-03183 | Alginate lyase Protein, Pseudomonas fluorescens, Recombinant (His & Myc) | Pseudomonas fluorescens | E. coli |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leu... | |||
TMPH-01594 | CT83 Protein-VLP, Human, Recombinant (His) | Human | HEK293 |
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane pro... | |||
TMPH-03230 | PHB depolymerase Protein, Ralstonia pickettii, Recombinant (His) | Ralstonia pickettii | E. coli |
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a ... | |||
TMPH-03578 | SCIN Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a ... | |||
TMPH-03232 | HSD17B13 Protein, Rat, Recombinant (His) | Rat | Baculovirus |
Plays an essential role in immune evasion by helping bacteria to resist complement-mediated killing by neutrophils. Inhibits the deposition of host C3b on bacterial surfaces and the release of the chemoattractant C5a by ... | |||
TMPH-03580 | Zinc metalloproteinase aureolysin Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli |
Plays an essential role in immune evasion by helping bacteria to resist complement-mediated killing by neutrophils. Inhibits the deposition of host C3b on bacterial surfaces and the release of the chemoattractant C5a by ... | |||
TMPY-06679 | CD55/DAF Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-00713 | CD55/DAF Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-01292 | CD55/DAF Protein, Human, Recombinant (His) | Human | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-02616 | CD55/DAF Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... | |||
TMPY-03004 | CD55/DAF Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It... |