aβ1-42 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S2227	Spinosin	Flavoayamenin	Others
	1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato...		Others
T60940	ChE/Aβ1-42-IN-1
	ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability. The IC50 values of ChE/Aβ1-42-IN-1 for AChE, BuChE and Aβ 1-42 aggregation are 0.062, 0.767 and 1.227 μM...
T64238	Aβ1–42 aggregation inhibitor 1
	Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), demonstrating IC50 values of 2.64 μM and 1.29 μM, respectively. At a concentration of 25 μM, it also redu...
T61388	HAChE/Aβ1-42-IN-1
	Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa...
T60671	MAO-B-IN-9		Beta Amyloid , Serotonin Transporter , Monoamine Oxidase
	MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-9 has neuroprotective effects against Aβ1-42-induced neuron...		Beta Amyloid , Serotonin Transporter , Monoamine Oxidase
T12532	PQM130		Beta Amyloid
	PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.		Beta Amyloid
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T21792	CGP 3466B maleate	Omigapil (Maleate),Omigapil maleate	Apoptosis
	CGP 3466B maleate (Omigapil maleate) is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil male...		Apoptosis
T4001	Euxanthone	1,7-Dihydroxyxanthone	Autophagy
	Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stres...		Autophagy
T3914	Saikosaponin C		Beta Amyloid , Caspase
	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.		Beta Amyloid , Caspase
T2873	Ginsenoside Rg2	Chikusetsusaponin I,Panaxoside Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2	Beta Amyloid , GSK-3 , NF-κB
	Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.		Beta Amyloid , GSK-3 , NF-κB
T23599	Ab42-IN-C2	Ab42-inhibitor-C2,Ab42 inhibitor-C2,Ab42 inhibitor C2
	Ab42-IN-C2 is an Aβ1-42 inhibitor.
T63689	Aβ-IN-2
	Aβ-IN-2 is a peptide inhibitor of Aβ1-42. Aβ-IN-2 inhibits the in vitro self-aggregation of Aβ1-42 by delaying the growth phase of the Aβ1-42 index or by reducing the number of protofibrils in the steady state.
T76434	Biotinyl-Amyloid β-Protein (1-42) (ammonium)
	Biotinyl-Amyloid β-Protein (1-42) ammonium, a biotinylated variant of Amyloid β-Protein (1-42), is utilized in research focused on the conversion of Aβ1-42 to Aβ1-40 in the brain [1].
T63307	AChE-IN-6
	AChE-IN-6 is an optimal multifunctional ligand that significantly inhibits AChE activity with IC50 values of 0.20 μM and 37.02 nM for EeAChE and HuAChE, respectively, and has anti-Aβ activity (IC50= 1.92 μM for self-indu...
T10530	BF 227		Others
	BF 227 is a candidate for an amyloid imaging probe for PET (Ki: 4.3 nM for Aβ1-42 fibrils).		Others
T10529	BF-168		Others
	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).		Others
T76464	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
	FITC-β-Ala-Amyloid β-Protein (1-42) ammonium, a fluorescein isothiocyanate (FITC)-tagged monomer peptide of Aβ1-42, is instrumental in Alzheimer’s disease pathogenesis [1].
TN4571	Mirabijalone D		Beta Amyloid
	Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.		Beta Amyloid
T68763	PQQ-TME
	PQQ-TME exhibits greater inhibitory activity against fibrillation of α-synuclein, Aβ1-42, and prion protein than PQQ. PQQ-TME also has twice the BBB permeability than PQQ in vitro.