Antioxidant agent-2

Antioxidant agent-2 (comp 3c), a BBB-penetrating and selective metal ion chelator, exhibits significant neuroprotective and hepatoprotective effects, making it beneficial for Alzheimer's disease research.

Antioxidant agent-20 (Compound 3d) exhibits potent anti-inflammatory and antioxidant activities. It reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 demonstrates photoprotective effects on UVB-exposed human skin keratinocytes (HaCaT) (IC50=5.13 µM) by activating Nrf2 HO-1 signaling and inhibiting the NF-κB pathway.

Antioxidant agent-21 is an antioxidant found in Pueraria montana var. lobata. This compound exhibits DPPH radical scavenging activity with an IC50 of 42 μg mL.

1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug mL. 4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM. 6. Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells. 7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against enveloped and non-enveloped viruses, suppressing virus propagation and modulating the expression of inflammatory cytokines for use as an anti-influenza virus agent [3]. It effectively inhibits the fusion of the virus with host cells [1] [2] and is an efficient inhibitor of SARS-CoV-2 in vitro [2].

1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses potent anti-proliferative and anti-invasive effects, it also has inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity. 3. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. 4. 1, 2, 3, 4, 6-Penta- O -galloyl-β- d -glucose has vasodilatory and anti-inflammatory effects, it dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO) cGMP signaling. 5. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose can decrease the level of extracellular hepatitis B virus (HBV) (IC5, 1. microg ml) in a dose-dependent manner, it also can reduce the HBsAg level by 25% at a concentration of 4 microg ml; the gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity, suggests that PGG could be a candidate for developing an anti-HBV agent. 6. 1, 2, 3, 4, 6-Penta-O-galloyl-β-D-glucose has anti-parasitic activity, displays an EC5 value of 67 μM, at least 6.6-fold more effective than the standard drug benznidazole against trypomastigote forms of T. cruzi.

1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3. Eriodictyol may be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness inAtopic dermatitis.

1. Artemitin (Erianthin) has anti-inflammatory activity. 2. Artemitin (Erianthin) protects endothelial function by acting as antioxidant and antiapoptotic agent and through the activation of ERK1 2 and Akt. 3. Intravenous injection of Artemitin (Erianthin)(.75 mg kg) significantly reduces the hypertensive response to angiotensin I while increases the average length of bradykinin-induced hypotension.

Neuroprotective agent 5 (compound 28) acts as a brain-penetrating agent with anti-neuroinflammatory, antioxidant, and neuroprotective properties. It exhibits potent inhibition of nitric oxide (NO) with an EC50 of 0.49 μM and suppresses the release of pro-inflammatory mediators PGE2 and TNF-α. Additionally, it downregulates the expression of iNOS and COX-2 proteins, facilitating the polarization of BV-2 cells from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. Neuroprotective agent 5 also dose-dependently inhibits acetylcholinesterase (AChE) activity and the aggregation of Aβ42. This compound is useful for research into Alzheimer's disease.

Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant and protective agent against oxidative stress and apoptosis in human platelets. It is a Cox-2 inhibitor.

1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be a novel anti-breast-cancer bone me

1. Oxypeucedanin hydrate (Prangolarin Hydrate) has antioxidant activity. 2. Oxypeucedanin hydrate is an antimutagenic agent. 3. Oxypeucedanin hydrate exhibits carbohydrate metabolizing enzymes inhibitory effect.

1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristics. 5. 8-Gingerol seems to be effect

Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activities. Licochalcone C exhibit inhibitory activity with cytotoxicity in a rat basophilic leukaemia cell line, RBL-2H3. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells, it may be a potential adjuvant therapeutic agent for bladder cancer.

Vanicoside E is an antioxidant and antitumor agent that inhibits L-Tyrosine and L-DOPA with IC50 values of 45.23 μM and 189.96 μM, respectively [1] [2].

Antioxidant Agent-9, a peptide featuring the Asp-Trp sequence, exhibits antioxidant properties and demonstrates potential as an antiviral against SARS-CoV-2, possessing an affinity strength comparable to that of Chloroquine and Favipiravir [1] [2].

Polygalacturonic acid (Galacturonic acid polymer), a transparent colloid, constitutes a significant portion of the cell wall. It is employed in the synthesis of silver nanoparticles (AgNPs), serving both as an antioxidant and anti-inflammatory agent to shield cells from the harmful impacts of elevated reactive oxygen species (ROS) and to expedite wound healing. Additionally, Polygalacturonic acid nanoparticles exhibit antibacterial properties [1] [2].

Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits antioxidant and anti-inflammatory properties by inhibiting oxidative stress-induced cell death and neuroinflammation through the suppression of Keap1, COX-2, and iNOS. It demonstrates low acute toxicity in mice with an LD50 of 1000 mg kg [1].

Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity with an IC50 value of 15.44 nM, and effectively inhibits tumor cell growth in Hela, Hep G2, and Caco-2 cells, with respective IC50 values of 395.26 nM, 400.4 nM, and 24.6 nM [1].

Antioxidant Agent-16 (Product 2) exhibits potent antioxidant activity, as demonstrated by its IC50 value of 6.93 ppm [1].

Compound 2 (Antioxidant agent-4) is a potent antioxidant with notable antilipid peroxidative properties [1].

JE-133, an optically active isochromane-2H-chromene conjugate, displays both antioxidant and anti-inflammatory properties. As a neuroprotective agent, it effectively counters neuronal oxidative damage through modulation of the PI3K Akt and MAPK signaling pathways. Additionally, JE-133 can suppress lipopolysaccharide (LPS)-induced neuroinflammation by influencing the JAK STAT and Nrf2 signaling pathways [1] [2].

Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotective effects on cells under oxidative

Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. It (100 ug disc) displays potential anticandidal effect against Candia albica