Home Tools
Log in
Cart

Search Result

Search Results for " antiangiogenic "

Targets

77

Compounds

16

Natural Products

26

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T79364 Antiangiogenic agent 4 Akt
Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].
T72363 Antiangiogenic agent 3
Antiangiogenic agent 3 is a potent antiangiogenic agent. Antiangiogenic agent 3 is an inhibitor of human umbilical vein endothelial cells (HUVEC). Antiangiogenic agent 3 inhibits HUVEC migration and chemotactic motilitie...
T62931 Antiangiogenic agent 2
Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.
T21593 AAL-993 VEGFR
AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...
T29797 AKB-6899 AKB6899 VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...
T8742 G5-7 JAK2 inhibitor G5-7 Apoptosis , JAK
JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for g...
T6027 Delanzomib CEP-18770 Apoptosis , NF-κB , Proteasome
Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylglutamyl activities of the proteosome.
T1792L Regorafenib monohydrate Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...
T41003 KG5 Raf , FLT , PDGFR , c-Kit
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.
T3289 Amifostine Ethyol,WR2721,Gammaphos Others , HIF/HIF Prolyl-Hydroxylase
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T6381 Amifostine trihydrate Ethyol trihydrate,WR2721,Amifostine Others , HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
T21334 Bucillamine DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019 VEGFR , Antioxidant
Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and...
T1792 Regorafenib BAY 73-4506,Fluoro-Sorafenib Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.
T2586 Cabozantinib XL184,BMS-907351 Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
Cabozantinib (BMS-907351) (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 nM).
T5164 Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T16545 Pivanex Pivalyloxymethyl butyrate,AN-9 Apoptosis , HDAC , Bcr-Abl
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.
T19668 Tiomolibdate diammonium Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,Coprexa Others
Tiomolibdate diammonium (NSC-286644) is an inhibitor of superoxide dismutase 1 (SOD1) exerting antiangiogenic and antitumor activities. Tiomolibdate diammonium inhibits the activities of cuproenzymes, including SOD1 and ...
T2456 Tivozanib AV-951,KRN951 VEGFR , PDGFR , Ephrin Receptor
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.
T73368 UniPR505 Ephrin Receptor
UniPR505 is a potent EphA2 antagonist (IC50: 0.95 µM), a novel 3α-carbamoyloxy derivative with antiangiogenic properties.
T1996 Defactinib PF-04554878,VS-6063 FAK
Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
T2644 (E)-Daporinad Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866 NAMPT , Transferase , Autophagy
(E)-Daporinad (FK866) is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities.
T1178 Temozolomide NSC 362856,TZM,CCRG 81045,TMZ Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy.
T2577 Dienogest STS 557 Apoptosis , Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy
Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therap...
T21746 Terameprocol tetramethyl Nordihydroguaiaretic Acid,EM-1421 HIV Protease
Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol sh...
T13178 Toceranib PHA 291639E,SU11654 VEGFR , PDGFR , c-Kit
Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitu...
T6091 CP-673451 VEGFR , PDGFR , c-Kit
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors.
T16380 OGT 2115 Others
OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM).
T1608 ADH-1 trifluoroacetate Exherin trifluoroacetate Dehydrogenase
ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-c...
T76941 Carotuximab DE-122,TRC105 TGF-beta/Smad , Immunology/Inflammation related
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab h...
T15181 DuP-697 COX
DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic...
T10883L CRA-026440 hydrochloride CRA-026440 hydrochloride(847460-34-8 Free base) HDAC
CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM...
T22443 Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI Apoptosis
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk...
T14871 Carboxyamidotriazole Orotate L-651582 Orotate,CAI Orotate Calcium Channel
Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate (L-651582 Orotate) is the o...
T6695 Tasquinimod ABR-215050 HDAC
Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac...
T15616 JNJ-10198409 JNJ-​10198409 PDGFR
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, ant...
T26047 Razoxane, (R)- ICRF-186,ICRF186,NSC-169779,ICRF 186,NSC 169779
Razoxane, (R)- shows antiangiogenic effects.
T24657 YLT192 YLT 192,YLT-192
YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.
T70609 Bisnafide mesylate
Bisnafide is a Naphthalimide Analogue that acts as DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent. Antiangiogenic agents can normalize tumor vessels and promote the delivery of cytotoxic agent...
T2358L ENMD-2076 tartrate ENMD-2076,L-(+) Tartrate salt of ENMD-981693,ENMD2076,ENMD 2076
ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.
T25290 DAT1 DAT-1,DAT 1
DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin.
T71488 Cremastranone
Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.
T37377 Aminohexylgeldanamycin
Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].
T70724 GSK-2256098 HCl
GSK-2256098 HCl is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
T28348 PD 404182 PD404182,PD-404182
PD-404182, an inhibitor of KDO 8-P synthase (Ki = 26 nM), is a otential antibiotic of gram negative bacteria. PD-404182 also exhibits antiviral and antiangiogenic activity in vitro.
T69487 ZK-261557
ZK-261557 is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.
T15234 ENMD-1198 IRC 110160,ENMD-119,ENMD 1198 HIF , STAT
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T69460 TSRI265
TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.
T71208 GO-Y078
GO-Y078 is an antiangiogenic curcumin analog which inhibits actin stress fiber formation, thereby resulting in mobility inhibition.
T25159 Bisnafide DMP 840
Bisnafide is a Naphthalimide Analogue that acts as a DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent that can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites...
T11930 M8891 Others
M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor(IC50 :54nM;Ki:4.33 nM).M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates ...

Compounds

Antiangiogenic agent 4
T79364
Synonym:
Target: Akt
Antiangiogenic agent 3
T72363
Synonym:
Target:
Antiangiogenic agent 2
T62931
Synonym:
Target:
AAL-993
T21593
Synonym:
Target: VEGFR
AKB-6899
T29797
Synonym: AKB6899
Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF
G5-7
T8742
Synonym: JAK2 inhibitor G5-7
Target: Apoptosis, JAK
Delanzomib
T6027
Synonym: CEP-18770
Target: Apoptosis, NF-κB, Proteasome
Regorafenib monohydrate
T1792L
Synonym:
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy
KG5
T41003
Synonym:
Target: Raf, FLT, PDGFR, c-Kit
Amifostine
T3289
Synonym: Ethyol,WR2721,Gammaphos
Target: Others, HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate
T6381
Synonym: Ethyol trihydrate,WR2721,Amifostine
Target: Others, HIF/HIF Prolyl-Hydroxylase
Bucillamine
T21334
Synonym: DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019
Target: VEGFR, Antioxidant
Regorafenib
T1792
Synonym: BAY 73-4506,Fluoro-Sorafenib
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy
Cabozantinib
T2586
Synonym: XL184,BMS-907351
Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit
Cabozantinib hydrochloride
T5164
Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351
Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR
Pivanex
T16545
Synonym: Pivalyloxymethyl butyrate,AN-9
Target: Apoptosis, HDAC, Bcr-Abl
Tiomolibdate diammonium
T19668
Synonym: Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,Coprexa
Target: Others
Tivozanib
T2456
Synonym: AV-951,KRN951
Target: VEGFR, PDGFR, Ephrin Receptor
UniPR505
T73368
Synonym:
Target: Ephrin Receptor
Defactinib
T1996
Synonym: PF-04554878,VS-6063
Target: FAK
(E)-Daporinad
T2644
Synonym: Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866
Target: NAMPT, Transferase, Autophagy
Temozolomide
T1178
Synonym: NSC 362856,TZM,CCRG 81045,TMZ
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Dienogest
T2577
Synonym: STS 557
Target: Apoptosis, Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy
Terameprocol
T21746
Synonym: tetramethyl Nordihydroguaiaretic Acid,EM-1421
Target: HIV Protease
Toceranib
T13178
Synonym: PHA 291639E,SU11654
Target: VEGFR, PDGFR, c-Kit
CP-673451
T6091
Synonym:
Target: VEGFR, PDGFR, c-Kit
OGT 2115
T16380
Synonym:
Target: Others
ADH-1 trifluoroacetate
T1608
Synonym: Exherin trifluoroacetate
Target: Dehydrogenase
Carotuximab
T76941
Synonym: DE-122,TRC105
Target: TGF-beta/Smad, Immunology/Inflammation related
DuP-697
T15181
Synonym:
Target: COX
CRA-026440 hydrochloride
T10883L
Synonym: CRA-026440 hydrochloride(847460-34-8 Free base)
Target: HDAC
Triglycidyl isocyanurate
T22443
Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI
Target: Apoptosis
Carboxyamidotriazole Orotate
T14871
Synonym: L-651582 Orotate,CAI Orotate
Target: Calcium Channel
Tasquinimod
T6695
Synonym: ABR-215050
Target: HDAC
JNJ-10198409
T15616
Synonym: JNJ-​10198409
Target: PDGFR
Razoxane, (R)-
T26047
Synonym: ICRF-186,ICRF186,NSC-169779,ICRF 186,NSC 169779
Target:
YLT192
T24657
Synonym: YLT 192,YLT-192
Target:
Bisnafide mesylate
T70609
Synonym:
Target:
ENMD-2076 tartrate
T2358L
Synonym: ENMD-2076,L-(+) Tartrate salt of ENMD-981693,ENMD2076,ENMD 2076
Target:
DAT1
T25290
Synonym: DAT-1,DAT 1
Target:
Cremastranone
T71488
Synonym:
Target:
Aminohexylgeldanamycin
T37377
Synonym:
Target:
GSK-2256098 HCl
T70724
Synonym:
Target:
PD 404182
T28348
Synonym: PD404182,PD-404182
Target:
ZK-261557
T69487
Synonym:
Target:
ENMD-1198
T15234
Synonym: IRC 110160,ENMD-119,ENMD 1198
Target: HIF, STAT
TSRI265
T69460
Synonym:
Target:
GO-Y078
T71208
Synonym:
Target:
Bisnafide
T25159
Synonym: DMP 840
Target:
M8891
T11930
Synonym:
Target: Others
1 2
Cat No. Product Name Synonyms Targets
TN1112 Morellic acid Others
Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity.
T3776 Rhapontigenin Protigenin P450 , Antibacterial , Antifungal
Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...
T1011 Itraconazole R51211 P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T1335 Mycophenolic acid Mycophenolate,RS-61443 Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal
Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T3S2027 Rubusoside Others
1. Rubusoside is a natural sweetener . 2. Rubusoside is a solubilizing agent with antiangiogenic and antiallergic properties.
T3878 Raddeanin A NSC382873,Anemodeanin A,Raddeanin R3 Apoptosis , HDAC
Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.
T4S0999 (2S)-Isoxanthohumol Isoxanthohumol Virus Protease , HSV
1. (2S)-Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol with antioxidant, anti-inflammatory, and antiangiogenic ...
T7032 Eupatorin Others , P450
Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...
T3864 Erianin BCL , Antibacterial
Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metaboli...
T2S0886 Terrestrosin D Apoptosis , Others
Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action...
T5S2343 Acetylshikonin Acetyl shikonin Others , P450 , AChE
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...
T40942 (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, an antiangiogenic homoisoflavonoid, exhibits activity against human retinal microvascular endothelial cells.
TN2892 3,5,7-Trihydroxychromone Others
3,5,7-Trihydroxychromone exhibits weak antiangiogenic activity.
TMA1743 Ergosterol peroxide ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
TN2553 1-Methyl-2-undecyl-4(1H)-quinolone 1-Methyl-2-undecylquinolin-4(1H)-one MAO
1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinol...
T36749 Herboxidiene
Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00948 Endostatin Protein, Mouse, Recombinant (His) Mouse Human Cells
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑termi...
TMPY-00979 HRG/HPRG Protein, Human, Recombinant (His) Human HEK293
Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-01030 TFPI Protein, Human, Recombinant (His) Human HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. Wit...
TMPH-02636 Elastin Protein, Mouse, Recombinant (His) Mouse E. coli
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
TMPH-02637 Embigin Protein, Mouse, Recombinant (His) Mouse in vitro E. coli expression system
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
TMPH-01213 DNASE1L3 Protein, Human, Recombinant (His) Human Baculovirus
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma gr...
TMPK-00867 EMAP-II/AIMP1 Protein, Mouse, Recombinant (His) Mouse E. coli
The potent antiangiogenic and proinflammatory protein Endothelial Monocyte Activating Polypeptide II (EMAP II) has been described as a mediator of pulmonary vascular and alveolar formation and its expression is inversely...
TMPK-00474 IL-22RA1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o...
TMPY-01868 TIMP-2 Protein, Human, Recombinant Human HEK293
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompas...
TMPY-04287 IL-22RA1 Protein, Rat, Recombinant (His) Rat HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal...
TMPY-04286 IL-22RA1 Protein, Rat, Recombinant (hFc) Rat HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal...
TMPY-00933 TIMP-2 Protein, Human, Recombinant (hFc) Human HEK293
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompas...
TMPY-04087 IL-22RA1 Protein, Canine, Recombinant (His) Canine HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal...
TMPY-04002 IL-22RA1 Protein, Canine, Recombinant (hFc) Canine HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal...
TMPJ-00292 CD36 Protein, Human, Recombinant (hFc) Human Human Cells
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPJ-00685 BAI3 Protein, Human, Recombinant (His) Human Human Cells
Human Brain-Specific Angiogenesis Inhibitor 3 (BAI3) is a 177 kDa seven-span transmembrane (TM) protein, which is thought to be a member of the secretin receptor family. It is synthesized by neurons of the CNS and likely...
TMPY-05179 TFPI Protein, Human, Recombinant (His), Biotinylated Human HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. Wit...
TMPY-00928 TFPI Protein, Mouse, Recombinant (His) Mouse HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. Wit...
TMPY-04000 Angiopoietin-like 7 Protein, Canine, Recombinant (hFc) Canine HEK293
ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04788 HRG/HPRG Protein, Rat, Recombinant (His) Rat HEK293
Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-04001 Angiopoietin-like 7 Protein, Canine, Recombinant (His) Canine HEK293
ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04004 Angiopoietin-like 7 Protein, Rhesus, Recombinant (His) Rhesus HEK293
ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04501 Angiotensinogen Protein, Rat, Recombinant (His) Rat HEK293
Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essenti...
TMPY-02232 Angiotensinogen Protein, Mouse, Recombinant (His) Mouse HEK293
Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essenti...
TMPY-01232 Angiotensinogen Protein, Human, Recombinant (His) Human HEK293
Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essenti...
TMPH-02374 OmpK36 Protein, Klebsiella pneumoniae, Recombinant (His) Klebsiella pneumoniae E. coli
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi...
Endostatin Protein, Mouse, Recombinant (His)
TMPJ-00948
Species: Mouse
Expression System: Human Cells
HRG/HPRG Protein, Human, Recombinant (His)
TMPY-00979
Species: Human
Expression System: HEK293
TFPI Protein, Human, Recombinant (His)
TMPY-01030
Species: Human
Expression System: HEK293
Elastin Protein, Mouse, Recombinant (His)
TMPH-02636
Species: Mouse
Expression System: E. coli
Embigin Protein, Mouse, Recombinant (His)
TMPH-02637
Species: Mouse
Expression System: in vitro E. coli expression system
DNASE1L3 Protein, Human, Recombinant (His)
TMPH-01213
Species: Human
Expression System: Baculovirus
EMAP-II/AIMP1 Protein, Mouse, Recombinant (His)
TMPK-00867
Species: Mouse
Expression System: E. coli
IL-22RA1 Protein, Cynomolgus, Recombinant (His)
TMPK-00474
Species: Cynomolgus
Expression System: HEK293
TIMP-2 Protein, Human, Recombinant
TMPY-01868
Species: Human
Expression System: HEK293
IL-22RA1 Protein, Rat, Recombinant (His)
TMPY-04287
Species: Rat
Expression System: HEK293
IL-22RA1 Protein, Rat, Recombinant (hFc)
TMPY-04286
Species: Rat
Expression System: HEK293
TIMP-2 Protein, Human, Recombinant (hFc)
TMPY-00933
Species: Human
Expression System: HEK293
IL-22RA1 Protein, Canine, Recombinant (His)
TMPY-04087
Species: Canine
Expression System: HEK293
IL-22RA1 Protein, Canine, Recombinant (hFc)
TMPY-04002
Species: Canine
Expression System: HEK293
CD36 Protein, Human, Recombinant (hFc)
TMPJ-00292
Species: Human
Expression System: Human Cells
BAI3 Protein, Human, Recombinant (His)
TMPJ-00685
Species: Human
Expression System: Human Cells
TFPI Protein, Human, Recombinant (His), Biotinylated
TMPY-05179
Species: Human
Expression System: HEK293
TFPI Protein, Mouse, Recombinant (His)
TMPY-00928
Species: Mouse
Expression System: HEK293
Angiopoietin-like 7 Protein, Canine, Recombinant (hFc)
TMPY-04000
Species: Canine
Expression System: HEK293
HRG/HPRG Protein, Rat, Recombinant (His)
TMPY-04788
Species: Rat
Expression System: HEK293
Angiopoietin-like 7 Protein, Canine, Recombinant (His)
TMPY-04001
Species: Canine
Expression System: HEK293
Angiopoietin-like 7 Protein, Rhesus, Recombinant (His)
TMPY-04004
Species: Rhesus
Expression System: HEK293
Angiotensinogen Protein, Rat, Recombinant (His)
TMPY-04501
Species: Rat
Expression System: HEK293
Angiotensinogen Protein, Mouse, Recombinant (His)
TMPY-02232
Species: Mouse
Expression System: HEK293
Angiotensinogen Protein, Human, Recombinant (His)
TMPY-01232
Species: Human
Expression System: HEK293
OmpK36 Protein, Klebsiella pneumoniae, Recombinant (His)
TMPH-02374
Species: Klebsiella pneumoniae
Expression System: E. coli
Cat No. Product Name
L4800 Angiogenesis related Compound Library

1370 compounds
A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
TargetMol