βenolase

SF2312 is a natural phosphonate antibiotic produced by Actinobacillus microsporus and is a potent inhibitor of the glycolytic enzyme enolase.SF2312 has antimicrobial activity and inhibits bacterial growth against both Gram-negative and Gram-negative bacteria. SF2312 inhibits human recombinant ENO1 and ENO2.

Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor.

AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.