(±)-Evodiamine

(±)-Evodiamine is an alkaloid isolated from Evodiae fructus and a topoisomerase I inhibitor. It also inhibits adipocyte differentiation and diabetes by downregulating IGF-1/HIF-1α and IL-6/STAT pathways. As an inhibitor of NF-κB activation, it suppresses invasion, promotes apoptosis, and inhibits TNF-induced Akt activation.

3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. It enhances the expression of glucose transporter 1 (GLUT1) and inhibits topoisomerase I/II activity. Additionally, 3-Fluoro-evodiamine glucose induces apoptosis and causes cell cycle arrest at the G2/M phase. This compound demonstrates anti-tumor activity both in vivo and in vitro, with no significant toxicity observed.

Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.

Dehydroevodiamine (Standard) is a reference standard for research and analysis in studies involving Dehydroevodiamine. Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Hydroxyevodiamine is a natural product

Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3/ASC/IL-1 axis activation.

CRC-IN-1 (compound (-) -15h) is an effective agent against colorectal cancer (CRC) both in vitro and in vivo, and it is a derivative of the anticancer substance Evodiamine.

1-Methyl-2-undecyl-4(1H)-quinolone, along with dihydroevocarpine and evodiamine, should serve as chemical markers for the quality control of Evodia rutaecarpa (Juss.) Benth. This compound selectively inhibits type B MAO (MAO-B) activity with an IC(50) value of 15.3 microM using the substrate kynuramine, while not inhibiting type A MAO (MAO-A) activity. It can mitigate high phosphate-induced calcification in human aortic valve interstitial cells (HAVICs) by inhibiting phosphate cotransporter (PiT-1) gene expression and exhibits moderate antiangiogenic activity against human tumor cells.