Zinc Ion Probe

Zinquin ethyl ester is a cell membrane-penetrating and selective fluorescent probe for zinc ions that measures intracellular levels of Zn(2+) and Ca(2+) ions and can be used to stain early embryos.

TSQ is a zinc fluorescent probe and zinc fluorescent chelator that binds to zinc to form a complex that induces apoptosis and can be used for imaging zinc proteins (λmax ~470 nm.) Light emitted by TSQ can be quenched by the Zn(2+) chelator, TPEN.

ZnAF-1F, with a Kd value of 2.2 nM, serves as a powerful fluorophore and is effective as fluorescent probes for Zn2+ in cellular applications. It exhibits an excitation wavelength (λ excitation) of 489 nm and an emission wavelength (λ emission) of 514 nm [1] [2] [3].

ZnAF-1, a zinc sensor compound, utilizes a fluorescein-based structure incorporating the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit. Its primary function lies in the detection of Zn2+ ions. Through its binding capability, ZnAF-1 achieves a 1:1 stoichiometry with Zn(II).

5-Br-PAPS, a highly specific Zn 2+ metallochromic indicator, is utilized in assays to measure free Zn 2+ by forming a deeply colored red Zn 2+ complex [1].

Meldola blue serves as a biosensor for measuring lactate in serum, utilizing screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) and coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.

Zinquin is a fluorescent sensor used in the observation of reactive Zn2+ (λex: 364 nm, em: 385 nm).

Zinquin AM ester, the AM ester form of Zinquin, is a fluorescent dye commonly used as a sensor for cellular Zn^2+ status [1].

ZnAF-2, 6-iso- is a cell-impermeable, high-affinity Zn2-specific fluorescent probe (Kd = 2.7 nM) that remains relatively non-fluorescent until it binds to Zn2 in a stoichiometric (1:1) ratio, resulting in an approximately 51-fold increase in fluorescence intensity. It shows minimal affinity for Ca2, Mg2, Na, or K.

Zincon sodium is a premier colorimetric reagent for detecting zinc and copper ions in aqueous solutions and can also be utilized for determining zinc, copper, and cobalt ions in metalloproteins [1].

ZnAF-2F DA is a versatile dye that plays a critical role in biological research. It assists in observing and analyzing cellular structures, tracking biomolecules, evaluating cell functions, distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms. Its applications span from fundamental scientific research to diverse clinical diagnostics. Additionally, dyes are extensively utilized in traditional areas like textile dyeing and emerging sectors including functional textile processing, food pigments, and dye-sensitized solar cells.

ZnAF-2DA is available for testing Zn(2+) fluorescence as a Zn(2+) probe (after esterase hydrolysis).

PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, exhibits an 85 nm redshift in emission upon Zn 2+ induction. This cell membrane-permeable probe effectively images Zn 2+ within living cells [1].