Magnesium ion indicator

Mag-Fluo-4 AM is a Mg 2+ (magnesium ion) dye and a low-affinity Ca 2+ (calcium ion) dye and fluorescent indicator with Kd of 4.7 mM and 22 µM, respectively, that localizes Ca 2+ in the lumen of endoplasmic reticulum-like tubules in many cell types, and is commonly used in live cell assays.

KMG-104AM is a selective fluorescein-derived magnesium fluorescent membrane-permeable probe. It is successfully used to Intracellular 3D Mg2+ Imaging.

Mem-C1C18, a polarity-sensitive fluorescent probe, exhibits superior plasma membrane anchoring and high brightness, alongside a sensitive alteration in fluorescence lifetime in response to environmental polarity changes. This compound facilitates the quantification of plasma membrane polarity fluctuations during ferroptosis [1].

Mag-Fura-2 AM, a cell-permeable fluorescent compound, serves as a selective indicator for magnesium ions (Mg2+), demonstrating significant preference for Mg2+ over other bivalent ions including zinc (Zn2+), copper (Cu2+), and calcium (Ca2+). It notably exhibits over 13,000-fold greater selectivity for Mg2+ compared to Ca2+ (Mg2+Kd = 1.9 nM vs. Ca2+Kd = 25 μM). The excitation and emission peak wavelengths are 369 nm and 511 nm, respectively. Further, Mag-Fura-2 AM is utilized as an indirect measure of ATP consumption or production due to its magnesium ion sensitivity.

Compound 3, formally known as ethyl benzo[6,7]-4-oxo-4H-quinolizine-3-carboxlate, serves as a Mg 2+ selective fluorescent indicator [1].

Mag-indo-1/AM, a cell-permeable fluorescent indicator for Mg2+ and Ca2+ (Ex=340-390 nm, Em=410-490 nm), is used to determine intracellular Mg2+ and Ca2+ concentrations [1][2].

BAPTA Tetrasodium is a selective fluorescent chelator for calcium. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+.

Mag-Indo-1 tetrapotassium salt is a cell-impermeable fluorescent probe designed for detecting Mg2+ [1].

Mag-Fura-2 tetrapotassium, a UV-excitable fluorescent Mg²⁺/Ca²⁺ indicator (Ex=334-360 nm, Em=510 nm), is used to determine Mg²⁺ and Ca²⁺ concentrations [1] [2].