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Sophora

  • Kurarinone
    T5S099334981-26-5
    Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response.
    • $39
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  • Sophoridine
    T33396882-68-4
    Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
    • $50
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  • Genistin
    T2882529-59-9
    Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities
    • $60
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  • Aloperine
    T637756293-29-9
    Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
    • $45
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  • (-)-Sophoranone
    TN222123057-55-8In house
    (-)-Sophoranone is a natural product from Sophora subprostrata.
    • $480
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  • Kurarinol
    TN1840855746-98-4
    Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.
    • $2,320
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  • Sophorabioside
    TN22182945-88-2
    Sophorabioside is a natural product from Sophora japonica.
    • $440
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  • Sophoflavescenol
    TN2217216450-65-6
    Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects. Sophoflaves
    • $657
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  • Puerol B
    TN4858112343-17-6
    (+/-)-Puerol B shows inhibitory activity on AGEs formation in vitro.
    • $870
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  • (2S)-2'-Methoxykurarinone
    TN1215270249-38-2
    (2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone displays cytotoxic activity against human myeloid leukemia HL-60 cells.
    • $58
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  • 8-Prenylkaempferol
    TN134728610-31-3
    8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and
    • $1,560
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  • 2,4,6,6-Tetramethyl-3(6H)-pyridinone
    TN2709203524-64-5
    2,4,6,6-Tetramethyl-3(6H)-pyridinone is a natural product for research related to life sciences. The catalog number is TN2709 and the CAS number is 203524-64-5.
    • $360
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  • Kushenol X
    TN1847254886-77-6
    Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
    • $2,289
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  • Kushenol C
    TN439999119-73-0
    Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan
    • $1,329
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  • Kushenol B
    TN439899217-64-8
    Kushenol B is a natural product for research related to life sciences. The catalog number is TN4398 and the CAS number is 99217-64-8.
    • $153
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  • Sophoraflavanone I
    TN5038136997-69-8
    Sophoraflavanone I is a natural product from Sophora moorcroftiana.
    • $342
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  • Isowighteone
    TN544568436-47-5
    Isowighteone, a compound that is not naturally produced in this species, accumulated by medicago truncatula hairy roots expressing LaPT1, indicates a strategy for metabolic engineering of novel antimicrobial compounds in legumes; it may have antimicrobial
    • $2,289
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  • Kushenol L
    TN1844101236-50-4
    Kushenol L is a natural product of Sophora, Fabaceae. The catalog number is TN1844 and the CAS number is 101236-50-4. Kushenol L can be used as a reference standard.
    • $640
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  • Kushenol K
    TN1843101236-49-1
    Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus types I and II.
    • $760
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  • Kushenol W
    TN1846254886-76-5
    Kushenol W is a natural product
    • $920
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  • Kuraridine
    TN439734981-25-4
    Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
    • $2,198
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  • Baptifoline
    TN3488732-50-3
    Baptifoline has cytotoxic activity.
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  • 6-Methylgenistein
    TN317997575-49-0
    6-Methylgenistein is a natural product from Sophora dunnii.
    • $1,980
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  • N-Methylcytisine
    T5S0994486-86-2
    1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of .1 mM, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki=7 nM).
    • $59
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  • Sepinol
    TN499372061-63-3
    Sepinol is a natural product for research related to life sciences. The catalog number is TN4993 and the CAS number is 72061-63-3.
    • $8,189
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  • Sophoranol
    TN22203411-37-8
    (+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. It also shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion.
    • $700
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  • Leachianone G
    TN5463152464-78-3
    Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Leachianone G shows potent antiviral
    • $555
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  • Kushenol E
    T821499119-72-9
    Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity.
    • $261
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  • 3-Hydroxy-2-methylpyridine
    T59011121-25-1
    3-Hydroxy-2-methylpyridine could as a promising molecular scaffold for the future development of novel fibrillization inhibitors.
    • $41
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  • Trifolirhizin
    T4S09986807-83-6
    Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer activities.Trifolirhizin shows in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells. Trifolirhizin inhibits acetylcholine mediated airway smooth muscle (ASM) contraction or directly relaxes pre-contracted ASM independent of β 2 -adrenoceptors.
    • $34
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  • Homopterocarpin
    TN4223606-91-7
    Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property
    • $460
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  • alpha-Isowighteone
    TN338665388-03-6
    alpha-Isowighteone is a natural product for research related to life sciences. The catalog number is TN3386 and the CAS number is 65388-03-6.
    • $590
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  • 6-Hydroxywogonin
    TN317376844-70-7
    6-Hydroxywogonin is a natural product for research related to life sciences. The catalog number is TN3173 and the CAS number is 76844-70-7.
    • $570
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  • Kushenol A
    TN184199217-63-7
    Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
    • $320
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  • Matrine
    T2870519-02-8
    Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
    • $36
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  • Isokurarinone
    TN178152483-02-0
    Isokurarinone is a natural product from Sophora flavescens Ait.
    • $156
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  • Kushenol I
    TN184299119-69-4
    Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumerinum.
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    • Neosophoramine
      TN464452932-74-8
      Neosophoramine is a natural product of Sophora, Fabaceae. The catalog number is TN4644 and the CAS number is 52932-74-8. Neosophoramine can be used as a reference standard.
      • $630
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    • Oxymatrine
      T275416837-52-8
      Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.It can also inhibit iNOS expression and TGF - β / Smad pathway.
      • $41
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      TargetMol | Citations Cited
    • Puerol A
      TN5672152784-32-2
      Puerol A exhibits potent inhibitory effects on aldose reductase with IC50 values of 6.4 uM. dl-Puerol A has antioxdiant activity, it shows inhibitory effects on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro.
      • $660
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    • Sophoraflavanone H
      TN5037136997-68-7
      Sophoraflavanone H is a natural product from Sophora moorcroftiana.
      • $2,559
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    • Leachianone A
      TN185697938-31-3
      Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
      • $73
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    • Sophocarpine
      T66776483-15-4
      Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
      • $45
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    • 6-Methoxywogonin
      TN30963162-45-6
      6-Methoxywogonin shows weak anti-inflammatory effect.
      • $540
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    • Sophoracarpan A
      TN50351674359-82-0
      Sophoracarpan A is a natural product from Sophora tomentosa L.
      • $64
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    • Sophoracarpan B
      TN50361674359-84-2
      Sophoracarpan B is a natural product from Sophora tomentosa L.
      • $590
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    • 8-Lavandulylkaempferol
      TN3287883859-83-4
      8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows inhibitory activities against aldose reductase, with the the IC50 of 0.79 microM.
      • $670
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    • Allomatrine
      T6S1010641-39-4
      Lumichrome is an endogenous compound in humans, produced by photodegradation of riboflavin. It utilizes a p53-dependent mechanism to inhibit growth and induce apoptosis in human lung cancer cells.
      • $35
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    • Kushenol N
      TN1845102490-65-3
      Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells .
      • $630
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    • Sophoraflavanone G
      T5S100097938-30-2
      Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
      • $41
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      TargetMol | Citations Cited