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Uremia Modeling

Uremia represents the end-stage phase of chronic kidney disease (CKD), characterized by severe metabolic disturbances and toxin accumulation. Common models include long-term adenine feeding and 5/6 nephrectomy combined with a high-protein diet. These models are used to investigate toxin clearance mechanisms, complication pathogenesis, and advanced renal replacement therapies.

cyclosporin a
T094559865-13-3
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).
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