mTOR

The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T67704	MTOR inhibitor 9e	1144075-40-0	98.80%
T67704	mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.
T6072	BGT226 maleate	1245537-68-1	98.78%
T6072	BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
T67706	MTOR inhibitor 9c	1144075-36-4	98.73%
T67706	mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.
T6251	PF-04691502	1013101-36-4	98.63%
T6251	PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
T14886	Cbz-B3A	1884710-81-9	98.63%
T14886	Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.
T4488	GSK-25	874119-56-9	98.59%
T4488	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
T6303L	CCT128930 hydrochloride	2453324-32-6	98.55%
T6303L	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest...
T3514	CZ415	1429639-50-8	98.44%
T3514	CZ415 is a potent and highly selective mTOR inhibitor.
T5S0506	Rotundic acid	20137-37-5	98.43%
T5S0506	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (N...
T6103	VS-5584	1246560-33-7	98.41%
T6103	VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.
T67701	MTOR inhibitor 9f	1144075-42-2	98.39%
T67701	mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.
T2475	KU-0063794	938440-64-3	98.35%
T2475	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.
T36200	AZD 3147	1101810-02-9	98.34%
T36200	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI...
T6731	WYE-354	1062169-56-5	98.31%
T6731	WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selec...
T36316	MTOR inhibitor-8	2489196-70-3	98.11%
T36316	mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, whic...
T5472	PQR620	1927857-56-4	98.11%
T5472	PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
T9950	ElteN378	1421366-99-5	98.09%
T9950	ElteN378 is a highly potent synthetic inhibitor of FKBP12 with Ki of 0.5 nM, a low atomic weight ligand with affinity comparable to that of the macrolide Rapamyc...
T1537	Rapamycin	53123-88-9	98.09%
T1537	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity...
T3986	SF2523	1174428-47-7	98.06%
T3986	SF2523 is a highly selective and potent inhibitor.
T16156	MT 63-78	1179347-65-9	98.03%
T16156	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathway...