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PAD

In enzymology, a protein-arginine deiminase is an enzyme that catalyzes a form of post translational modification called arginine de-imination or citrullination. his chemical reaction induces citrullinated proteins formation with altered structure and function, leading to numerous pathological diseases, including inflammation and autoimmune diseases. These pathologies established the PADs as therapeutic targets and multiple PAD inhibitors are known. Humans encode five PADs, designated PADs 1-4 and PAD6. Of the five PAD isozymes (PAD1, 2, 3, 4 and 6), only four (PADs1-4) are catalytically active. PAD activity is tightly regulated by Ca2+ and PADs contain 4 (PAD1), 5 (PAD3, 4) or 6 (PAD2) Ca2+-binding sites. Dysregulated PAD activity, most notably PAD2 and PAD4, is associated with multiple inflammatory diseases (e.g., rheumatoid arthritis) as well as cancer, and PAD inhibitors, such as Cl-amidine and BB-Cl-amidine, show efficacy in multiple preclinical animal models of disease.
Cat. No. Product name CAS No. Purity Chemical Structure
T9828 N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide 1965308-76-2 98%
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide is a racemic form of Cl-amidine (S enantiomer). Cl-amidine is an orally active peptidylargin...
T8861 GSK199 1549811-53-1 98%
GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium).
T10831L Cl-amidine hydrochloride 1373232-26-8 98%
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in can...
T10482 BB-Cl-Amidine 1802637-39-3 98%
BB-Cl-Amidine is an inhibitor of peptidyl arginine deminase (PAD).
T22277 BMS-P5 1549811-36-0 98%
BMS-P5 is a novel Peptidylarginine Deiminase 4 (PAD4) inhibitor that blocks delays progression of multiple myeloma and formation of neutrophil extracellular tr...
TQ0067 GSK484 hydrochloride 1652591-81-5 98%
GSK484 hydrochloride (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC...
T24105 GSK121 1652591-80-4 98%
GSK121 is an inhibitor of selective PAD4.
T2205 Acefylline 652-37-9 98%
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T22277L BMS-P5 free base 1550371-22-6 98%
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Del...
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide
T9828
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide is a racemic form of Cl-amidine (S enantiomer). Cl-amidine is an orally active peptidylargin...
GSK199
T8861
GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium).
Cl-amidine hydrochloride
T10831L
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in can...
BB-Cl-Amidine
T10482
BB-Cl-Amidine is an inhibitor of peptidyl arginine deminase (PAD).
BMS-P5
T22277
BMS-P5 is a novel Peptidylarginine Deiminase 4 (PAD4) inhibitor that blocks delays progression of multiple myeloma and formation of neutrophil extracellular tr...
GSK484 hydrochloride
TQ0067
GSK484 hydrochloride (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC...
GSK121
T24105
GSK121 is an inhibitor of selective PAD4.
Acefylline
T2205
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
BMS-P5 free base
T22277L
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Del...