P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T10632	Bucolome	841-73-6	99.83%
T10632	Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.
T7088	Diflubenzuron	35367-38-5	99.83%
T7088	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also be...
T6215	Abiraterone Acetate	154229-18-2	99.83%
T6215	Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of me...
T3355	Naloxegol oxalate	1354744-91-4	99.82%
T3355	Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
T2770	Gentiopicroside	20831-76-9	99.8%
T2770	Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki ...
T1010	Verapamil hydrochloride	152-11-4	99.79%
T1010	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T2143	Bergapten	484-20-8	99.77%
T2143	Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
T21548	PF-4981517	1390637-82-7	99.77%
T21548	PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 μM,17 μM...
T3411	Curdione	13657-68-6	99.76%
T3411	Curdione ((+)-Curdione) inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Cu...
T0100L	Atazanavir	198904-31-3	99.76%
T0100L	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T6050	TAK-700	426219-18-3	99.75%
T6050	TAK-700 (Orteronel) (Orteronel) is a potent and highly selective human 17, 20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs...
T3736	Olivetol	500-66-3	99.74%
T3736	Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in...
T11218	ε-Viniferin	62218-08-0	99.73%
T11218	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1...
TN1691	Glabrol	59870-65-4	99.72%
TN1691	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T1650	Chlorzoxazone	95-25-0	99.72%
T1650	Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
T15641	K777	233277-99-1	99.71%
T15641	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 a...
T5715	(E)-Flavokawain A	37951-13-6	99.7%
T5715	(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-depende...
T0100	Atazanavir sulfate	229975-97-7	99.67%
T0100	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with ...
T70489	Enerisant HCl	1152749-07-9	99.66%
T70489	Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins....
T2175	Apigenin	520-36-5	99.66%
T2175	Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for i...