NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T10808	CHPG sodium salt	1303993-73-8	98%
T10808	CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
T3005	4-Hydroxychalcone	20426-12-4	98%
T3005	4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
T6S1572	Sauchinone	177931-17-8	98%
T6S1572	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
T11060	DMAPT	870677-05-7	98%
T11060	DMAPT (Dimethylamino Parthenol) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor. For cell populations in AML cells, the...
TN1576	Diallyl disulfide	2179-57-9	98%
TN1576	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
T25150	BI-69A11	1233322-09-2	98%
T25150	BI-69A11 is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt...
T2947	Indole-3-carbinol	700-06-1	98%
T2947	Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T1296	4-Aminosalicylic acid	65-49-6	98%
T1296	Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T5795	Suberosin	581-31-7	98%
T5795	Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mo...
TN1664	Ganoderic acid H	98665-19-1	98%
TN1664	Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting i...
TN1016	Kukoamine A	75288-96-9	98%
TN1016	Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T0646	5-Aminosalicylic Acid	89-57-6	98%
T0646	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T3627	IQ-1S free acid	23146-22-7	98%
T3627	IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cart...
T3147	Pyrrolidinedithiocarbamate ammonium	5108-96-3	98%
T3147	Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
T5681	ETHYL CAFFEATE	102-37-4	98%
T5681	In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-re...
T4S2063	Tetrahydrocoptisine	4312-32-7	98%
T4S2063	1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
T5688	Micheliolide	68370-47-8	98%
T5688	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5660	Menthone	10458-14-7	98%
T5660	Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
T6S1487	Ginsenoside Rg5	186763-78-0	98%
T6S1487	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production a...
TN5284	Sodium Houttuyfonate	83766-73-8	98%
TN5284	Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including ...