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MLK

Mixed-lineage kinases (MLKs) are serine/threonine-directed protein kinases. MLKs are members of mitogen-activated-protein kinase (MAPK) modules that contain c-Jun amino-terminal kinase (JNKs) or p38 MAPKs.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13564L2 AZ7550 trimesylate salt 2319837-99-3 98%
AZ7550 trimesylate salt
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of n...
T2696 PRT062607 hydrochloride 1370261-97-4 99.93%
PRT062607 hydrochloride
PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases...
T2048 LY-364947 396129-53-6 99.65%
LY-364947
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
T6104 Cerdulatinib hydrochloride 1369761-01-2 99.23%
Cerdulatinib hydrochloride
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for ...
T6904 Necrosulfonamide 1360614-48-7 99.17%
Necrosulfonamide
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of recep...
T11520 GW806742X 579515-63-2 99.07%
GW806742X
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity...
T24160 IM-54 861891-50-1 99.05%
IM-54
IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
T41027 MLKL-IN-2 899759-16-1 98.61%
MLKL-IN-2
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
T7129 (E/Z)-Necrosulfonamide 432531-71-0 98%
(E/Z)-Necrosulfonamide
(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.
T13564 AZ7550 1421373-99-0 97.07%
AZ7550
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T6057 URMC-099 1229582-33-5 98%
URMC-099
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
AZ7550 trimesylate salt
T13564L2
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of n...
PRT062607 hydrochloride
T2696
PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases...
LY-364947
T2048
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
Cerdulatinib hydrochloride
T6104
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for ...
Necrosulfonamide
T6904
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of recep...
GW806742X
T11520
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity...
IM-54
T24160
IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
MLKL-IN-2
T41027
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
(E/Z)-Necrosulfonamide
T7129
(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
TargetMol