MLK

Mixed-lineage kinases (MLKs) are serine/threonine-directed protein kinases. MLKs are members of mitogen-activated-protein kinase (MAPK) modules that contain c-Jun amino-terminal kinase (JNKs) or p38 MAPKs.

Cat. No.	Product name	CAS No.	Purity
T13564L2	AZ7550 Mesylate (1421373-99-0 free base)	T13564L2	98%
T13564L2	AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T6104	Cerdulatinib hydrochloride	1369761-01-2	98%
T6104	Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T7129	Necrosulfonamide	432531-71-0	98%
T7129	Necrosulfonamide is a novel inhibitor of MLKL.
T24160	IM-54	861891-50-1	99.05%
T24160	IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
T11520	GW806742X	579515-63-2	99.07%
T11520	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity...
T6904	Necrosulfonamide	1360614-48-7	99.17%
T6904	(E)-Necrosulfonamide is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-...
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T2696	PRT062607 hydrochloride	1370261-97-4	99.93%
T2696	PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
T2048	LY-364947	396129-53-6	99.96%
T2048	LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.