GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.

Cat. No.	Product name	CAS No.	Purity
TN1717	Guvacine	498-96-4	98%
TN1717	Guvacine can enhance the inhibition of spinal neurones by GABA.
T11686	Isotanshinone I	20958-17-2	98%
T11686	Isotanshinone I with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I has inhibitory activity against α-glucosidase and for...
T12043	(-)-Bicuculline methobromide	73604-30-5	98%
T12043	(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .
TN5147	Tilifodiolide	126724-95-6	98%
TN5147	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
T16794	RO 4938581	883093-10-5	98%
T16794	RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, ...
T14938	CGP 36742	123690-78-8	98%
T14938	CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful ...
TN3351	Aflatrem	70553-75-2	98%
TN3351	Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocam...
T16717	Radequinil	219846-31-8	98%
T16717	Radequinil is a benzodiazepine receptor partial inverse agonist. Rade quinil binds to GABA(-) and GABA(+) ligand (Kis: 5.15 and 6.11 nM, respectively).
T21793	CGP 35348	123690-79-9	98%
T21793	CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after n...
T28479	PZ-II-029	164025-44-9	98%
T28479	PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.
T16539	Piperazine citrate	144-29-6	98%
T16539	Piperazine Citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmi...
T8268	6,2'-Dihydroxyflavone	92439-20-8	98%
T8268	6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
T32098L	Homocarnosine acetate		98%
T32098L	Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-infla...
T37190	L-Allylglycine	16338-48-0	98%
T37190	L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
T3173	DAA-1106	220551-92-8	98%
T3173	DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), acting as a potent and selective agonist at the peripheral benzodiazepine ...
T22616	Bretazenil	84379-13-5	98%
T22616	GABAA benzodiazepine site partial agonist
T77568	6,7-dimethylisatin	20205-43-0	98%
T77568	6,7-Dimethylisatin inhibits hGAT3 with IC50 of 108 μM. 6,7-Dimethylisatin also inhibits hBGT1, hGAT2.
TN1308	6-Hydroxyflavanone	4250-77-5	98%
TN1308	6-Hydroxyflavanone, a compound extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxyge...
T8193	α-Thujone	546-80-5	98%
T8193	Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T5880	Aminooxyacetic acid hemihydrochloride	2921-14-4	98%
T5880	Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.