69
7
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2433 | NU 7026 | NU7026,DNA-PK Inhibitor II,LY293646 | Apoptosis , ATM/ATR , DNA-PK , PI3K |
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR. | |||
T15789 | LTURM34 | DNA-PK , PI3K , PI4K | |
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K . | |||
T4339 | YU238259 | DNA-PK , Others | |
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays. | |||
T2461 | PIK-90 | DNA-PK , PI3K | |
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) . | |||
T6100 | Torin 2 | Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy | |
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2... | |||
T3986 | SF2523 | DNA-PK , Epigenetic Reader Domain , PI3K , mTOR | |
SF2523 is a highly selective and potent inhibitor. | |||
T3541 | CC-115 | CC 115 | DNA-PK , PI3K , mTOR |
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). | |||
T4459 | PK11000 | DNA Alkylator/Crosslinker | |
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. | |||
T79165 | DNA-PK-IN-10 | DNA-PK | |
DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1]. | |||
T61751 | DNA-PK-IN-3 | ||
DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tum... | |||
T62034 | DNA-PK-IN-7 | ||
DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5). | |||
T62191 | DNA-PK-IN-5 | ||
DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits the activity of DNA-PKcs, significantly reduces tumour DNA repair and induces apoptosis. DNA-PK-IN-5 improves the sensitivity of tumour tissue to radiothe... | |||
T61857 | DNA-PK-IN-4 | ||
DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly imp... | |||
T9760 | IC 86621 | DNA-PK | |
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell... | |||
T62648 | DNA-PK-IN-1 | ||
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research. | |||
T61633 | DNA-PK-IN-2 | ||
DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications i... | |||
T61533 | DNA-PK-IN-9 | ||
DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1]. | |||
T61370 | DNA-PK-IN-6 | ||
DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 ampli... | |||
T61828 | DNA-PK-IN-8 | ||
DNA-PK-IN-8 is a potent, selective, and orally active inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.8 nM. It displays synergistic antiproliferative effects across various cancer cel... | |||
T6557 | KU-0060648 | KU0060648 | DNA-PK , PI3K , mTOR |
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM. | |||
T6276 | KU-57788 | NU7441 | DNA-PK , CRISPR/Cas9 |
NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM). | |||
T2667 | PIK-75 | Apoptosis , DNA-PK , PI3K | |
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM). | |||
T6143 | PI-103 | PI103,PI 103 | Apoptosis , DNA-PK , PI3K , mTOR , Autophagy |
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK). | |||
T25399 | ETP-45658 | ETP45658,ETP 45658 | DNA-PK , PI3K , mTOR |
ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively... | |||
T7122 | AZD-7648 | DNA-PK | |
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. | |||
T3586 | Compound 401 | 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one | DNA-PK |
Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K. | |||
T6883 | Samotolisib | GTPL8918,LY3023414 | DNA-PK , PI3K , mTOR , Autophagy |
Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, ... | |||
T25069 | AMA-37 | DNA-PK Inhibitor V,ArylMorpholine Analog 37,AMA 37 | |
AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor. | |||
T13017 | STL127705 | Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione | DNA-PK , Others |
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM. | |||
T2008 | LY294002 | LY 294002,NSC 697286,SF 1101 | Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy |
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ... | |||
T4079 | LY-294002 hydrochloride | SF 1101,LY 294002,NSC 697286 | PI3K |
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation... | |||
T2287 | PIK-75 hydrochloride | PIK-75 HCl,PIK-75 | Apoptosis , DNA-PK , PI3K |
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays. | |||
TQ0031 | Nedisertib | M3814 | DNA-PK |
Nedisertib (M3814) (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM). | |||
T9498 | BAY-8400 | DNA-PK | |
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combination with targeted alpha therapies. BAY-8400 can be used for... | |||
T1826 | PI3K-IN-1 | Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 | DNA-PK , PI3K |
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. | |||
T6612 | NU6027 | ATM/ATR , DNA-PK , CDK | |
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. | |||
T7014 | Voxtalisib | XL765,SAR245409 | DNA-PK , PI3K , mTOR |
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | |||
T62083 | Camonsertib | ATR inhibitor 4,RP-3500 | ATM/ATR |
Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR... | |||
T8637 | DMNB | 6-Nitroveratraldehyde | DNA-PK |
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c... | |||
T11067 | VX-984 | M9831 | DNA-PK |
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commo... | |||
T8651 | CAL-101 | (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib | PI3K |
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than... | |||
T2415 | PP121 | Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck | |
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM). | |||
T6319 | OSI-027 | ASP4786,OSI027 | DNA-PK , PI3K , mTOR , Autophagy |
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1. | |||
T2685 | KU-55933 | ATM Kinase Inhibitor | ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy |
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor. | |||
T12672 | (Rac)-Nedisertib | (Rac)-M3814 | DNA-PK |
(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM). | |||
T13444 | (R)-Nedisertib | (R)-M3814 | Others |
(R)-Nedisertib is a less active R-enantiomer of Nedisertib(IC50 in the range of 7-30 nM for DNA-PK). | |||
T6283 | Wortmannin | SL-2052,KY-12420 | ATM/ATR , DNA-PK , Serine/threonin kinase , PLK , PI3K , Antibiotic , Autophagy |
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy. | |||
T68192 | OK-1035 | ||
OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of conse... | |||
T24559 | NU-7163 | NU 7163,NU7163 | |
NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK. | |||
T69286 | IC87361 | ||
IC87361 is a potent and specific inhibitor of DNA-PK. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00476 | DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) | Dictyostelium discoideum | E. coli |
DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-02287 | Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa... | |||
TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... | |||
TMPK-00972 | PK-1/PROK1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r... | |||
TMPH-02315 | XRCC5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPH-02314 | XRCC5 Protein, Human, Recombinant (His & MBP) | Human | Baculovirus |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPY-02465 | PARP Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... |