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BMI-1

Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.

  • PRT4165
    T311031083-55-3
    PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
    • $38
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    TargetMol | Citations Cited
  • PTC-209
    T2345315704-66-6
    PTC-209 is a potent and selective BMI-1 inhibitor.
    • $47
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    TargetMol | Citations Cited
  • PTC-028
    T166801782970-28-8
    PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis.
    • $38
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  • Unesbulin
    T125751610964-64-1
    Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).
    • $89
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  • XMD8-92
    T18431234480-50-2
    XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
    • $48
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  • PTC-209 hydrobromide
    T61781217022-63-3
    PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
    • $51
    5 days
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