zo-1

KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)

BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.

BTZO-15 is a novel ARE activator, ameliorating DSS- and TNBS-induced colitis in rats.

2,3,5,6-Tetramethylbenzo-1,4-quinone is a quinone compound widely used in biochemical experiments and drug synthesis research.

Dibenzo-18-crown-6 is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Benzo-18-crown-6-ether (B18C6) is an organic compound used to create stable microcapsule responsive layers, which can be assembled into bilayer microcapsules. For instance, 18-Crown-6-ether is employed to prepare a responsive layer and then coated with a K+-stabilized G-quadruplex cross-linked hydrogel layer. When Mg2+ ions are present, 18-Crown-6-ether and K+ ions enable dissociation and locking with the G-quadruplex cross-linked layer, allowing for switchable controlled release of the load.

Benzo-15-crown-5-ether can serve as a chelating agent for sodium and potassium.

Bis(Benz-15-crown-5) [Bis[(Benzo-15-crowN-5)-4-methyl]pimelate] is a biochemical analysis reagent suitable for use in chemical synthesis.

4-Aminobenzo-12-crown-4 is a pharmaceutical intermediate used in the synthesis of various active compounds.

Puromycin aminonucleoside (NSC 3056) is an aminonucleoside antibiotic and a purine analog of puromycin. It can reversibly inhibit dipeptidyl peptidase and cytosolic alanine aminopeptidase, increase podocyte permeability by regulating ZO-1 in an oxidative stress-dependent manner, induce apoptosis, and promote the secretion of migrasomes. It is commonly used to induce nephrotic syndrome models in research.

SARS-CoV-2-IN-117 (Compound C19) is an inhibitor of the SARS-CoV-2 E protein. It effectively disrupts the interaction between the SARS-CoV-2 E protein and the host ZO-1 PDZ2 domain. This compound exhibits potent antiviral activity and significantly reduces viral replication. SARS-CoV-2-IN-117 is applicable for COVID-19 research.

Ethyl-3,4-dephostatin is a novel inhibitor of the interactions of CFTR-associated ligand and PSD-95/Dlg1/ZO-1 domain.

3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.