veratrum

The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

3,4-Dimethoxyphenylacetic acid (Homoveratrumic acid) is the papaverine intermediate, used to synthesis cardiovascular drugs.

Veratric acid (3,4-Dimethoxybenzoic acid) is a benzoic acid derivative from plants and fruits, possessing antioxidant, anti-inflammatory, and blood pressure-lowering properties.

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

2,3-Dimethoxybenzaldehyde (5,6-Dimethoxybenzaldehyde) is a benzoic acid analog, with high Antifungal activity (MIC=2.5 mM). 2,3-Dimethoxybenzaldehyde could be used for the synthesis of berberine.

Veratramine (NSC-23880)(NSC-17821; NSC-23880) is a potent signal transduction inhibitor for treating tumors.

1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.

Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervine has the potential to advance to t

Teinemine also known as Muldamine, is a phytosterol alkaloid isolated from Veratrum californicum. It is the acetate ester of the piperidine steroid teinemine.

Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation. Velutin has anti-inflammatory property. Velutin exhibits the greatest potency among all flavones which reduce TNF-α and IL-6 production.

Cycloposine, a steroidal alkaloid present in the roots and rhizomes of Veratrum californicum, is known to possess teratogenic properties.

(-)-Verazine is an antifungal agent isolated from the dried roots and rhizome of Veratrum maackii Regel, which induces DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. It has applications in research related to fungal infections and neurological diseases [1] [2].

Jervinone, an alkaloid metabolite derived from Veratrum, is isolated from the mold Cunninghamella echinulata [1].

Grandivine A, a steroid alkaloid, has been isolated from Veratrum grandiflorum [1].

Veratridine (Standard) is a reference standard for research and analysis in studies involving Veratridine. Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.

Veratrosine (Veratramine-beta-D-glucoside) is an alkaloid isolated from the herbs of Veratrum nigrum. Veratrosine exhibits feeble inhibition activity against platelet aggregation.

Pseudojervine (O-beta-D-Glucopyranosyljervine) is derived from Veratrum nigrum L. Pseudojervine exhibits feeble inhibition activity against platelet aggregation.