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target/NF_κB/2

" in TargetMol Product Catalog
  • Inhibitor Products
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    TargetMol | Activity
3-(7,7-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-1H-indole-7-carbonitrile
T97522759137-87-4In house
3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.
  • $148
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Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
T60001863589-52-0
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including diabetes, cardiovascular disease, bloo
  • $85
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sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate
T50009L144254-93-3
sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.
  • $37
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Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
T63898849150-59-0In house
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is the R-isomer of Aleglitazar.
  • $195
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Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine
T62750L2738485-99-7In house
rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.
  • $320
In Stock
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(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one
T83554491572-18-0
(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone featuring a complex bicyclic structure [1].
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Cucurbitacin B 2-O-beta-D-glucoside
TN153465247-27-0
Cucurbitacin B 2-o-α²-D-glucoside has anticancer activity.
  • $2,510
Backorder
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4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate
T8333197941-42-9
4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate is an α-arabinopyranosides analogue isolated from the aboveground parts of barley [1].
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Multi-target kinase inhibitor 2
T81739
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 values between 40 to 204 nM. It exhibits cytotoxic effects on HepG2, HeLa, MDA-MB-231, and MCF-7 cell lines, with IC50 values of 41, 57, 51, and 59 μM, respectively. Additionally, it induces cell cycle arrest and apoptosis specifically in HepG2 cells.
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DNA gyrase B-IN-2
T79240
DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition (IC 50 < 10 nM) and a broad-spectrum antibacterial effect, with minimum inhibitory concentrations below 0.03 μg/mL for most Gram-positive species and between 4–16 μg/mL for Gram-negative species including E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. DNA gyrase B-IN-2 is applicable in infection research [1].
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NF-κΒ activator 2
T399242375281-44-8
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].
  • $158
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AChE/BuChE/MAO-B-IN-2
T78679
AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM, indicating good in vitro blood-brain barrier (BBB) permeability. It is effective in reducing excessive AChE and BuChE levels associated with Alzheimer's disease (AD) and holds potential for use in anti-Alzheimer's research [1].
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2’-Deoxy-2’-fluoro-b-D-arabino-6-azauridine
TNU0302908129-24-8
2'-Deoxy-2'-fluoro-b-D-arabino-6-azauridine is a Nucleoside Derivative - 6-Aza-uridine; Fluoro-modified nucleoside; Arabino nucleoside.
  • Inquiry Price
7-10 days
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NF-κB-IN-2
T603571821386-63-3
NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.
  • $1,520
6-8 weeks
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1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
T66536256376-65-5
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.
    7-10 days
    Inquiry
    2-Amino-4-chloro-5-iodo-N2-pivaloyl-7-[2-deoxy-3,5-di-O- (4-methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine
    TNU1291199938-73-3
    2-Amino-4-chloro-5-iodo-N2-pivaloyl-7-[2-deoxy-3,5-di-O- (4-methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deazapurine nucleoside; Halo-nucleoside.
    • Inquiry Price
    7-10 days
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    2’-Amino-2’-deoxy-b-D-arabino-5-methyl uridine
    TNU0501135304-48-2
    Nucleoside Derivatives - 2’-Modified nucleosides; Amino nucleosides
    • Inquiry Price
    7-10 days
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    Dual AChE-MAO B-IN-2
    T621521801157-64-1
    Dual AChE-MAO B-IN-2 is a potent, dual inhibitor of AChE (IC50: 0.12 μM) and MAO B (IC50: 0.01 μM).Dual AChE-MAO B-IN-2 has potential for Alzheimer's disease studies.
    • $1,520
    6-8 weeks
    Size
    QTY
    1-(2-C-b-Methyl-b-D-ribofuranosyl)-5-nitropyridine-2(1H)-one
    TNU08002072145-17-4
    1-(2-C-b-Methyl-b-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyridine nucleoside; 2'-C-Methyl nucleoside.
    • Inquiry Price
    7-10 days
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    2-Amino-4-chloro-N2-pivaloyl-7-[2-deoxy-3,5-di-O-(4- methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine
    TNU12901878120-03-6
    2-Amino-4-chloro-N2-pivaloyl-7-[2-deoxy-3,5-di-O-(4- methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deazapurine nucleoside; Halo-nucleoside.
    • Inquiry Price
    7-10 days
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    5-(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine
    T644371265884-98-7
    5-(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64437.
      7-10 days
      Inquiry
      1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol
      TNU16411117893-19-2
      1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.
      • Inquiry Price
      7-10 days
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      (S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid
      T6616472120-71-9
      (S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66164 and the CAS number is 72120-71-9.
        7-10 days
        Inquiry
        N4-Benzoyl-2’-deoxy-2’-fluoro-b-D-arabinocytidine
        TNU1174
        N4-Benzoyl-2’-deoxy-2’-fluoro-b-D-arabinocytidine is a useful organic compound for research related to life sciences and the catalog number is TNU1174.
        • Inquiry Price
        7-10 days
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        2’-C-b-Methyl-4-deoyuridine
        TNU01141106032-88-5
        Nucleosides and Reagents - 4-Deoxypyrimidine nucleoside; 2’-C-Methyl nucleoside
        • Inquiry Price
        7-10 days
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        2’-b-C-Ethynyladenosine
        TNU0474640725-76-4
        2'-b-C-Ethynyladenosine is a Nucleoside Derivative - 2'-Modified nucleoside.
        • Inquiry Price
        7-10 days
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        7-(2-Deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
        TNU103293366-89-3
        Nucleoside Derivatives - 7-Deaza-purine nucleosides; 6-De-aminopurine nucleosides
        • Inquiry Price
        7-10 days
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        QTY
        1-(b-D-Xylofuranosyl)-2-thiouracil
        TNU03712305416-17-3
        Nucleoside Derivatives - Xylo-nucleosides, Thio-nucleosides
        • Inquiry Price
        7-10 days
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        2’-Deoxy-2’-fluoro-4’-thio-b-D-arabinouridine
        TNU0518941610-00-0
        2'-Deoxy-2'-fluoro-4'-thio-b-D-arabinouridine is a Nucleoside Derivative - Thio-nucleoside;Fluoro-modified -nucleoside.
        • Inquiry Price
        7-10 days
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        B-Raf IN 2
        T402842649372-20-1
        B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.
        • $52
        In Stock
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        1-(b-D-Ribofuranosyl)-5-nitropyridine-2(1H)-one
        TNU011359892-36-3
        1-(b-D-Ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyrimidine nucleoside.
        • Inquiry Price
        7-10 days
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        2’-Deoxy-2’-fluoro-b-D-arabino-2-thiouridine
        TNU03721006872-85-0
        Nucleoside Derivatives - Fluoro-modified nucleosides, 2’-Modified nucleosides, Thio-nucleosides
        • Inquiry Price
        7-10 days
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        7-Deaza-2’-deoxyguanosine;  2-Amino-7-(2-deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one
        TNU102786392-75-8
        Nucleoside Derivatives - 7-Deaza-purine nucleoside
        • Inquiry Price
        7-10 days
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        4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
        TNU0323124137-35-5
        4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 7-deaza-8-aza purine nucleoside.
        • Inquiry Price
        7-10 days
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        3’-b-Amino-2’,3’-dideoxyuridine
        TNU0971101062-04-8
        Nucleoside Derivatives - Amino-nucleosides, Xylo-nucleosides, 2’,3’-Didexoy nucleosides, 3’-Modified nucleosides
        • Inquiry Price
        7-10 days
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        6-chloro-purine-9-b-D-(2-O-acetyl-3,5-di-O-benzoyl)xylo-furanoside
        TNU1002132370-61-7
        Nucleoside Derivatives - Xylo-nucleoside; Halo-nucleoside; Scaffolds and Templates
        • Inquiry Price
        7-10 days
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        6-Chloro-2-fluoropurine-9-b-D-(3,5-bis-O-(p-toluoyl)-2-deoxy)riboside
        TNU1086
        Nucleoside Derivatives - Fluoro-modified nucleoside; Halo-nucleoside
        • Inquiry Price
        7-10 days
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        (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
        T6596842399-49-5
        (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one is a useful organic compound for research related to life sciences. The catalog number is T65968 and the CAS number is 42399-49-5.
          7-10 days
          Inquiry
          1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium chloride
          T64494719300-59-1
          1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium chloride is a useful organic compound for research related to life sciences and the catalog number is T64494.
            7-10 days
            Inquiry
            Monoamine Oxidase B inhibitor 2
            T60806
            Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective inhibitor of monoamine oxidase B (MAO-B) (IC50 = 1.33 nM) which can across the blood-brain barrier (BBB). Monoamine Oxidase B inhibitor 2 shows antioxidant and anti-neuroinflammatory activities which can be used in the study of Parkinson’s disease [1].
            • $1,520
            10-14 weeks
            Size
            QTY
            1-(5-O-Methoxytrityl-2-deoxy-b-D-xylofuranosyl)uracil
            TNU09282072145-82-3
            Nucleoside Derivatives - Xylo-nucleosides, 2’-Deoxy-nucleosides; ; Protected nucleosides with NH2/OH group
            • Inquiry Price
            7-10 days
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            2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride
            T65734138564-60-0
            2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65734 and the CAS number is 138564-60-0.
              7-10 days
              Inquiry
              3’-b-Amino-2’,3’-dideoxy-5’-O-methoxytrityl-5-methyluridine
              TNU0973204688-08-4
              3'-b-Amino-2',3'-dideoxy-5'-O-methoxytrityl-5-methyluridine is a Nucleoside Derivative - Amino-nucleoside, Xylo-nucleoside, 2',3'-Didexoy nucleoside, 3'-Modified nucleoside; Protected nucleoside with NH2/OH group.
              • Inquiry Price
              7-10 days
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              6-Amino-2,5-dihydro-2-(b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one
              TNU032285426-86-4
              6-Amino-2,5-dihydro-2-(b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one is a Nucleoside Derivative - 7-deaza-8-aza purine nucleoside.
              • Inquiry Price
              7-10 days
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              hMAO-B/MB-COMT-IN-2
              T60658
              hMAO-B/MB-COMT-IN-2 is a dual inhibitor of MAO-B/MB-COMT with IC 50s of 4.27 μΜ and 2.69 μΜ for hMAO-B and MB-COMT, respectively. hMAO-B/MB-COMT-IN-2 protects cells from oxidative damage that can be used in the neurodegeneration disease research, for example, Parkinson’s Disease (PD) [1].
              • $1,520
              10-14 weeks
              Size
              QTY
              6-Chloro-2-hydroxy-9-(2,3,5-tri-O-acetyl)-b-D-ribofuranosyl-9H-purine
              TNU1077161923-50-8
              Nucleoside Derivatives - Halo-nucleoside
              • Inquiry Price
              7-10 days
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              6-Amino-4-hydroxyamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
              TNU0325
              6-Amino-4-hydroxyamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU0325.
              • Inquiry Price
              7-10 days
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              QTY
              5-Naphthyl-b-methylaminocarbony-3’-O-acetyl-2’-O-methyluridine
              TNU00122095417-03-9
              Nucleoside Derivatives - 5-Modified pyrimidine nucleoside; 2’-Modified nucleoside; Protected nucleosides with NH2/OH open
              • Inquiry Price
              7-10 days
              Size
              QTY
              6-Amino-3-(furan-2-yl)-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
              TNU0390
              6-Amino-3-(furan-2-yl)-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.
              • Inquiry Price
              7-10 days
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              6-Amino-4-hydrozino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
              TNU0324
              6-Amino-4-hydrozino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU0324.
              • Inquiry Price
              7-10 days
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