sgi

SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.

SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.

SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.

Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .

Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.

RNAP-NusG-IN-1 is an inhibitor of RNAP-NusG. It exhibits antibacterial (bacterial) activity against Gram-positive bacteria, with the most potent effect observed in Streptococcus pneumoniae, where the minimum inhibitory concentration (MIC) is 1 μg/mL.

Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.

20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial cells(HUVEC) and has anti-angiogenesis activities.

MPS-Gαi3, a cell-penetrating peptide, facilitates drug delivery [1].

Aspergillus giganteus α-sarcin is a ribosome-inactivating protein that induces apoptosis in rhabdomyosarcoma cells (apoptosis). α-Sarcin is utilized for triggering apoptosis and inhibiting protein synthesis.

Lipopolysaccharides are endotoxins composed of lipopolysaccharide structures and serve as TLR-4 activators, triggering pathogen-associated molecular patterns (PAMP) of the immune system and inducing cellular secretion of vesicles. Extracted from the outer leaflet of the outer membrane of Gram-negative bacteria, they consist of an O-antigen-specific chain, a core oligosaccharide, and lipid A. Lipopolysaccharides, from P. gingivalis, refer specifically to the endotoxin derived from Porphyromonas gingivalis.