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Search Results for " selective,?retinoid "

12

Compounds

Cat No. Product Name Synonyms Targets
T7586 Trifarotene CD5789 Retinoid Receptor , Autophagy
Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).
T6410 Bexarotene Ro 26-4455,Targretin,LGD1069 Retinoid Receptor , Autophagy
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
T14912 CD3254 Retinoid Receptor
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.
T21714 BMS453 BMS 453,BMS-189453 Retinoid Receptor
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
T17209 UVI 3003 Retinoid Receptor , Autophagy
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).
TN6735 Bigelovin Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR 
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T24857 TBTC
TBTC is a selective agonist of retinoid X receptor α that acts by improving behavioral deficit in Alzheimer's disease model mice.
T71715 CU239
CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration.
T19703 LG100268 LG 100268,LG-100268
LG100268 is an effective and selective rexinoid and retinoid-X receptor agonist. LG100268 binds to the α, β, and γ RXR receptors (IC50 = 3-4 nM).
T69921 BRF110
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and str...
T37414 CAY10771
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)...
T14144 AGN-195183 Others
AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Target: RARα agonist Compoun...
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