s-23

S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

XDS-23 is a selective biofilm inhibitor with an IC50 value of 1.26 µM against Pseudomonas aeruginosa. It exhibits dual inhibitory effects on the LasI/LasR system and the Pseudomonas Quinolone Signal system, suppressing key virulence factors such as elastase, pyocyanin, and extracellular polysaccharides. In both in vitro and in vivo models, XDS-23 demonstrates synergistic antibacterial activity, enhancing the efficacy of various antibiotics with good safety profile. XDS-23 is applicable for research related to treating biofilm-mediated resistant Pseudomonas aeruginosa infections.

NS-2359 is a serotonin-norepinephrine-dopamine reuptake inhibitor.

S-23906-1 is a potential alkylating agent for solid tumors.

MRS-2339 is a P2X receptor activator.

MLS-2384 is a dual JAK/Src kinase inhibitor, suppressing growth of diverse cancer cells.

trans-23-Methyltetracos-2-enoyl-CoA (trans-23-Methyltetracos-2-enoyl-coenzyme A) is a derivative of coenzyme A.

1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.

Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-protease inhibitor used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.

3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the p38MAPK , and PI3K/Akt/mTOR/p70S6K pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].

Batabulin (T138067) is an antitumor compound that binds covalently and selectively to a subset of the β-tubulin isotypes, disrupting microtubule polymerization. This disruption affects cell morphology, induces cell-cycle arrest, and ultimately leads to apoptotic cell death.

3,3'-[Iminobis(methylene)]bis-2(3H)furanone is a useful organic compound for research related to life sciences and the catalog number is T123845.

ROS 234 dioxalate is a potent antagonist of H3 (pKB of 9.46 for Guinea-pig ileum H3-receptor).

LY223982 is an effective and selective LTB4 (leukotriene B4 receptor) antagonist that inhibits LTB4-induced neutrophil activation and transient leukopenia.

Naminidil (BMS-234303) is an ATP-sensitive potassium channel opener with vasodilatory activity that was developed as a topical medication candidate for the treatment of androgenic alopecia. Naminidil is used in research to investigate potassium channel–mediated vasodilation, hair follicle biology, and localized drug delivery strategies.

TCS 2314 (compound 3) is a potent and selective VLA-4 (α4β1 integrin; CD49d/CD29) antagonist with an IC50 of 4.4 nM. It exhibits high plasma clearance and low oral bioavailability in rats, making it suitable for asthma research.

Velneperit (S2367) is potent and selective neuropeptide Y (NPY) Y5 receptor under evaluating for treatment of obesity.

Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.

S234984 (Compound 13) is a molecular adhesive that specifically binds with KBTBD4 and HDAC2 to form a stable ternary complex. S234984 is applicable for cancer research.

RS 23579-190 is a highly selective 5-HT receptor antagonist in neuropharmacology. Capable of specifically blocking serotonin-mediated downstream excitatory postsynaptic potentials at picomolar concentrations, it is frequently used to dissect serotonergic signaling pathways within the gastrointestinal enteric nervous system and central cognitive networks.

Highly potent, selective P2Y1 receptor agonist

RS 23597-190 hydrochloride is an indole derivative and a potent, selective 5-HT4 receptor antagonist (pKi = 9.1). It acts by blocking 5-HT4-mediated cAMP accumulation with high selectivity, used for gastrointestinal motility and arrhythmia research.