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Search Results for " retina "
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Targets

NMDAR

29

Compounds

8

Natural Products

21

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T22733 DL-AP5 NMDAR
DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.
T6831 Etretinate Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359 Apoptosis , Others
Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of c...
T38219 11-cis Retinal
11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to for...
T29395 3-Diazirinophenylretinal
3-Diazirinophenylretinal is a bioactive chemical.
T34299 Retinaloxime trans-Retinaloxime
Retinaloxime is a retinoid.
T8600 N-ACETYLTRYPTAMINE Melatonin Receptor
N-ACETYLTRYPTAMINE is a partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase.
T22530 6-Chloromelatonin Melatonin Receptor , Dopamine Receptor
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...
T8736 Cidofovir dihydrate HPMPC,(S)-HPMPC,GS 0504 Others
Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ...
T68125 (Rac)-PD0299685 (Rac)-PF-299685 Calcium Channel
(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.
T38216 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol
1-Palmitoyl-2-oleoyl-3-arachidonoyl-rac-glycerol is a triacylglycerol that contains palmitic acid , oleic acid , and arachidonic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been found in lipid extrac...
T35505 (±)11-HDHA
(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelet...
T36607 (±)8-HDHA
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress...
T35512 (±)16-HDHA
(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stre...
T78197 5-Fluoromethylornithine dihydrochloride 5-FMOrn dihydrochloride
5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific, irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT), utilized in research pertaining to gyrate atrophy of the choroid and retina [1] [2]...
T35508 (±)13-HDHA
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 1...
TP1464 Risuteganib hydrochloride
Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order ...
T37532 Docosahexaenoyl Glycine
The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina an...
T36602 (±)4-HDHA
(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also...
T36606 (±)7-HDHA
(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and ...
TP2199 Rhodopsin peptide Others
Rhodopsin peptide is a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin is a biological pigment in photoreceptor cells of the retina that is responsible for the fir...
T81311 RASP-IN-1
RASP-IN-1 (Compound A), a lipophilic compound, serves as an inhibitor for macular degeneration and exhibits biological activity within the rabbit retina. In a mouse model [1], the administration of 14 C-RASP-IN-1 (10 mg/...
TP1749 IRBP (1-20), human
IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa gly...
T35504 (±)10-HDHA
(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of...
T37259 14(S)-HDHA
Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and...
T35497 (±)7(8)-EpDPA
Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenase...
T36601 (±)17-HDHA
(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of D...
T37503 Maresin 2 3R,14S-diHDHA
Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human mac...
T35509 (±)14-HDHA
(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelet...
T35578 Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th...

Compounds

DL-AP5
T22733
Synonym:
Target: NMDAR
Etretinate
T6831
Synonym: Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359
Target: Apoptosis, Others
11-cis Retinal
T38219
Synonym:
Target:
3-Diazirinophenylretinal
T29395
Synonym:
Target:
Retinaloxime
T34299
Synonym: trans-Retinaloxime
Target:
N-ACETYLTRYPTAMINE
T8600
Synonym:
Target: Melatonin Receptor
6-Chloromelatonin
T22530
Synonym:
Target: Melatonin Receptor, Dopamine Receptor
Cidofovir dihydrate
T8736
Synonym: HPMPC,(S)-HPMPC,GS 0504
Target: Others
(Rac)-PD0299685
T68125
Synonym: (Rac)-PF-299685
Target: Calcium Channel
1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol
T38216
Synonym:
Target:
(±)11-HDHA
T35505
Synonym:
Target:
(±)8-HDHA
T36607
Synonym:
Target:
(±)16-HDHA
T35512
Synonym:
Target:
5-Fluoromethylornithine dihydrochloride
T78197
Synonym: 5-FMOrn dihydrochloride
Target:
(±)13-HDHA
T35508
Synonym:
Target:
Risuteganib hydrochloride
TP1464
Synonym:
Target:
Docosahexaenoyl Glycine
T37532
Synonym:
Target:
(±)4-HDHA
T36602
Synonym:
Target:
(±)7-HDHA
T36606
Synonym:
Target:
Rhodopsin peptide
TP2199
Synonym:
Target: Others
RASP-IN-1
T81311
Synonym:
Target:
IRBP (1-20), human
TP1749
Synonym:
Target:
(±)10-HDHA
T35504
Synonym:
Target:
14(S)-HDHA
T37259
Synonym:
Target:
(±)7(8)-EpDPA
T35497
Synonym:
Target:
(±)17-HDHA
T36601
Synonym:
Target:
Maresin 2
T37503
Synonym: 3R,14S-diHDHA
Target:
(±)14-HDHA
T35509
Synonym:
Target:
Phosphatidylserines (sodium salt)
T35578
Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
Target:
Cat No. Product Name Synonyms Targets
T5256 All-trans-retinal All trans-Retinal,Retinaldehyde,Vitamin A aldehyde Others , Endogenous Metabolite
All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.
T19169 9-cis-Retinal Others
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and ma...
T5369 Docosahexaenoic Acid Cervonic acid,DHA Others , Endogenous Metabolite
Docosahexaenoic Acid (DHA) is an essential fatty acid and an omega-3 fatty acid abundant in brain and retina.
T0937 Riboflavin Vitamin B2,E101 Endogenous Metabolite
Riboflavin (E101) is a micronutrient that occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotid...
T3394 Timosaponin BII Prototimosaponin A III Beta Amyloid , Others , BACE
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the...
T1183 Retinol all-trans-Retinol,Vitamin A,Vitamin A1,Alphalin Others
Retinol (Alphalin) and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune r...
T4S0969 Obtusifolin Antioxidant , NF-κB
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...
T35577 Phosphatidylserines (bovine)
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th...

Natural Products

All-trans-retinal
T5256
Synonym: All trans-Retinal,Retinaldehyde,Vitamin A aldehyde
Target: Others, Endogenous Metabolite
9-cis-Retinal
T19169
Synonym:
Target: Others
Docosahexaenoic Acid
T5369
Synonym: Cervonic acid,DHA
Target: Others, Endogenous Metabolite
Riboflavin
T0937
Synonym: Vitamin B2,E101
Target: Endogenous Metabolite
Timosaponin BII
T3394
Synonym: Prototimosaponin A III
Target: Beta Amyloid, Others, BACE
Retinol
T1183
Synonym: all-trans-Retinol,Vitamin A,Vitamin A1,Alphalin
Target: Others
Obtusifolin
T4S0969
Synonym:
Target: Antioxidant, NF-κB
Phosphatidylserines (bovine)
T35577
Synonym:
Target:

Recombinant Proteins

Species：
Human (17)
Mouse (3)
Rat (1)
Expression System：
E. coli (10)
HEK293 Cells (8)
Baculovirus Insect Cells (3)
Tag：
C-6xHis (5)
His (4)
N-6xHis (4)
Tag Free (4)
C-His (1)
C-hFc (1)
His, GST (1)
N-His (1)
Cat No. Product Name Species Expression System
TMPY-03463 GCAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
GCAP1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 50.7 kDa and the accession number is P43080.
TMPY-03554 GCAP1 Protein, Human, Recombinant Human Baculovirus Insect Cells
GCAP1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 23.1 kDa and the accession number is P43080.
TMPJ-00842 FGF-2 Protein, Rat, Recombinant Rat E. coli
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. ...
TMPJ-00945 HPCAL1 Protein, Human, Recombinant (His) Human E. coli
Hippocalcin-Like Protein 1 (HPCAL1) is a neuron-specific calcium-binding member of the recoverin family which found in the retina and brain. HPCAL1 contains four EF-hand domains and it is highly similar to human hippocal...
TMPH-02888 SFRP5 Protein, Mouse, Recombinant (His) Mouse E. coli
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be ...
TMPJ-01299 RTBDN Protein, Human, Recombinant (His) Human HEK293 Cells
Human Retbindin is a 229 amino acid secreted protein that belongs to the folate receptor family. The gene that encodes retbindin exists as two alternatively spliced isoforms. Retbindin is first expressed in retina. It ma...
TMPJ-01134 CLUL1 Protein, Human, Recombinant (His) Human HEK293 Cells
Clusterin-Like Protein 1 (CLUL1) is a secreted protein that belongs to the clusterin family. CLUL1 is synthesized as a 466 amino acid precursor that contains a 20 amino acid signal sequence, and a 446 amino acid mature c...
TMPY-02955 CABP5 Protein, Human, Recombinant (His) Human E. coli
CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. ...
TMPJ-00265 Serpin F1 Protein, Mouse, Recombinant Mouse E. coli
Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and ...
TMPJ-00706 SNCG Protein, Human, Recombinant Human E. coli
Gamma-Synuclein (SNCG) is a member of the Synuclein protein family. Gamma-Synuclein is mostly expressed in the peripheral nervous system and retina. Gamma-Synuclein plays a role in neurofilament network integrity and may...
TMPJ-01398 ITM2B Protein, Human, Recombinant (His) Human HEK293 Cells
Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other ti...
TMPJ-00715 FGF-19 Protein, Human, Recombinant (His) Human E. coli
Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis...
TMPJ-00916 TIMP-2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP...
TMPY-02438 AKR1B1 Protein, Human, Recombinant (His) Human E. coli
Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest...
TMPJ-01130 NPTX1 Protein, Human, Recombinant (His) Human HEK293 Cells
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a...
TMPJ-00821 OM Protein, Human, Recombinant (His) Human E. coli
Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macropha...
TMPY-04761 Creatine kinase B Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical...
TMPJ-00292 CD36 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPY-01052 R-Cadherin/CDH4 Protein, Human, Recombinant (His) Human HEK293 Cells
The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) region...
TMPY-02248 Myocilin Protein, Human, Recombinant (His) Human HEK293 Cells
Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid o...
TMPY-02289 CIB2 Protein, Human, Recombinant (His) Human E. coli
Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is gen...
GCAP1 Protein, Human, Recombinant (His & GST)
TMPY-03463
Species: Human
Expression System: Baculovirus Insect Cells
GCAP1 Protein, Human, Recombinant
TMPY-03554
Species: Human
Expression System: Baculovirus Insect Cells
FGF-2 Protein, Rat, Recombinant
TMPJ-00842
Species: Rat
Expression System: E. coli
HPCAL1 Protein, Human, Recombinant (His)
TMPJ-00945
Species: Human
Expression System: E. coli
SFRP5 Protein, Mouse, Recombinant (His)
TMPH-02888
Species: Mouse
Expression System: E. coli
RTBDN Protein, Human, Recombinant (His)
TMPJ-01299
Species: Human
Expression System: HEK293 Cells
CLUL1 Protein, Human, Recombinant (His)
TMPJ-01134
Species: Human
Expression System: HEK293 Cells
CABP5 Protein, Human, Recombinant (His)
TMPY-02955
Species: Human
Expression System: E. coli
Serpin F1 Protein, Mouse, Recombinant
TMPJ-00265
Species: Mouse
Expression System: E. coli
SNCG Protein, Human, Recombinant
TMPJ-00706
Species: Human
Expression System: E. coli
ITM2B Protein, Human, Recombinant (His)
TMPJ-01398
Species: Human
Expression System: HEK293 Cells
FGF-19 Protein, Human, Recombinant (His)
TMPJ-00715
Species: Human
Expression System: E. coli
TIMP-2 Protein, Mouse, Recombinant (His)
TMPJ-00916
Species: Mouse
Expression System: HEK293 Cells
AKR1B1 Protein, Human, Recombinant (His)
TMPY-02438
Species: Human
Expression System: E. coli
NPTX1 Protein, Human, Recombinant (His)
TMPJ-01130
Species: Human
Expression System: HEK293 Cells
OM Protein, Human, Recombinant (His)
TMPJ-00821
Species: Human
Expression System: E. coli
Creatine kinase B Protein, Human, Recombinant (His)
TMPY-04761
Species: Human
Expression System: Baculovirus Insect Cells
CD36 Protein, Human, Recombinant (hFc)
TMPJ-00292
Species: Human
Expression System: HEK293 Cells
R-Cadherin/CDH4 Protein, Human, Recombinant (His)
TMPY-01052
Species: Human
Expression System: HEK293 Cells
Myocilin Protein, Human, Recombinant (His)
TMPY-02248
Species: Human
Expression System: HEK293 Cells
CIB2 Protein, Human, Recombinant (His)
TMPY-02289
Species: Human
Expression System: E. coli
Cat No. Product Name
L7110 Anti-Hypertension Compound Library

678 compounds
678 hypertension-related small molecules for high-throughput and high-content screening.

Libraries

Anti-Hypertension Compound Library
L7110
Compounds: 678
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