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1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for Alzheimer's disease therapy.

Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.

Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psoriasis-like skin inflammation by modulating the PI3K/AKT signaling pathway.

ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through inhibition of the NF-κB signaling pathway, in the regulation of antioxidant response through activation of the Nrf2 signaling pathway, and in the regulation of cell survival and proliferation through inhibition of the Akt signaling pathway.

Neuroprotective agent 5 (compound 28) acts as a brain-penetrating agent with anti-neuroinflammatory, antioxidant, and neuroprotective properties. It exhibits potent inhibition of nitric oxide (NO) with an EC50 of 0.49 μM and suppresses the release of pro-inflammatory mediators PGE2 and TNF-α. Additionally, it downregulates the expression of iNOS and COX-2 proteins, facilitating the polarization of BV-2 cells from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. Neuroprotective agent 5 also dose-dependently inhibits acetylcholinesterase (AChE) activity and the aggregation of Aβ42. This compound is useful for research into Alzheimer's disease.

Neuroprotective agent 6 (Compound Y12) functions as an antioxidant and displays prominent neuroprotective effects in both oxygen-glucose deprivation/reperfusion (OGD/R) induced cell models and transient middle cerebral artery occlusion (tMCAO) induced animal models. Additionally, this compound shows significant metal chelating activity towards Cu2+.

Neuroprotective agent 7 (Compound 13) is a brain-penetrant neuroprotective agent that significantly reduces the infarct area in MCAO rat models. It serves as a potent neuroprotective compound and is applicable for studies related to cerebral ischemia and similar conditions.

Neuroprotective agent 10 (Compound 11c) is a brain-penetrant neuroprotective compound. It effectively scavenges ABTS radicals (IC50 for scavenging: 9.20 μM), DPPH radicals (IC50 for scavenging: 7.09 μM), and superoxide anion radicals (inhibition rate: 48.4%). Additionally, it mitigates oxidative damage induced by H2O2 and neuroinflammation induced by lipopolysaccharides, demonstrating antiepileptic properties. Neuroprotective agent 10 shows promise for research in epilepsy and neuroprotection.

Neuroprotective agent 8 (compound AA-9) is an orally active neuroprotective agent that functions through antioxidant stress reduction and anti-inflammatory mechanisms. In a rat model of MCAO ischemic stroke, it activates PGC-1α and inhibits the NLRP3 inflammasome.

Neuroprotective agent 9 (compound 7) is a neuroprotective compound with promising potential for use in research on neuronal damage, including conditions such as stroke, brain injury, and neuropathic pain.

Neuroprotective agent 12 is an orally active compound capable of crossing the blood-brain barrier, offering significant neuroprotective properties. It exhibits robust antioxidant and anti-inflammatory effects, markedly inhibiting cell death induced by glutamate and acrolein. This agent reduces the expression of PDE4B while elevating levels of HO-1, p-CREB, and BDNF. In a traumatic brain injury (TBI) mouse model, Neuroprotective agent 12 demonstrates potent neuroprotection and holds potential for research into TBI and other central nervous system disorders.

Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.

Neuroprotectant-7 is a neuroprotectant for Alzheimer's disease. It displays significant neuroprotection and antioxidative properties. It also can cross the blood-brain barrier.

beta-Neuroprotectin is a (3H)TCP binding inhibitor and provides protection against NMDA mediated neuronal cell death at low concentration.

17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)976-987(2011)

Protected meropenem is a useful organic compound for research related to life sciences. The catalog number is T66294 and the CAS number is 96036-02-1.

Compound 11, labeled as a weak Hepatoprotective agent-1, is a naturally occurring substance extracted from the fruits of Arctium lappa L. It demonstrates modest hepatoprotective effects when applied at a concentration of 10 μM [1].

Hepatoprotective agent-1 (compound 1b) functions as a hepatoprotective agent, exhibiting anti-inflammatory, antiapoptotic, and antifibrotic effects [1].

Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, not only demonstrates significant hepatoprotective effects but also possesses antiapoptotic activity. It effectively mitigates chemically induced increases in hepatic indicators, which are symptomatic of liver damage [1].

Neuroprotective Agent 2 (Compd 28) is a potent neuroprotective compound with protective effects in both salsolinol and glutamate-induced neurodegeneration models, reducing oxidative stress and caspase-3/7 activity in the glutamate model [1].

Compound 21a (Neuroprotective agent 3) is an antioxidant that demonstrates neuroprotective properties by significantly enhancing neuronal viability and inducing neuroprotection. Additionally, it improves neurological deficit scores in an in vivo model of transient cerebral ischemia [1].

Compound 24a, also known as Neuroprotective agent 4, is a novel and effective small molecule antioxidant with neuroprotective effects. It is utilized in the study of ischemic stroke and related diseases [1].

Neuroprotectin B is a cyclic peptide that safeguards cultured chicken neurons from excitotoxicity induced by glutamate and kainic acid.

Neuroprotectin A (Complestatin A) is a cyclic peptide that safeguards cultured chicken brain neurons from excitotoxicity caused by glutamate and kainic acid.