phospholipid

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Palmitoyloleoylphosphatidylcholine) is a phospholipid commonly found in cell membranes, with cholesterol compositions ranging from 0 to 60 mol%.

Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect.

Magainin II is a member of the antimicrobial peptides family

Imeglimin hydrochloride (EMD 387008 hydrochloride) is an oral hypoglycemic agent. Imeglimin improves insulin sensitivity, inhibits the production of reactive oxygen species, increases mitochondrial DNA, and improves mitochondrial function.

Lipofundin S is an emulsion containing soybean oil, glycerol, and soy phosphatides.

GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound effectively induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells with an EC50 value of 0.16 µM. Additionally, at a dose of 200 mg/kg, GPX4 24 elevates malondialdehyde (MDA) levels in both kidney and plasma of mice, highlighting its impact on lipid peroxidation.

Phospholipid-PEG-Biotin (MW 1000 and MW 3400) is a derivative of a phospholipid and PEG, featuring a biotin moiety and a phospholipid connected via a linear PEG linker. This compound, particularly with a molecular weight of 3400, is capable of interacting with avidinylated antibodies. It finds applications in modifying the surface of liposomes, cells, and pancreatic islets, making it useful in cell transplantation [1] [2] [3].

Phospholipid-PEG-Biotin (MW 2000), a biotin-labeled phospholipid PEG derivative, is designed for modifying the surfaces of liposomes, cells, and pancreatic islets intended for cell transplantation. This compound integrates the properties of three distinct components: phospholipids, which are lipids featuring a hydrophilic "head" and two hydrophobic "tails"; PEG, a low-toxicity, water-soluble, hydrophilic polymer; and biotin, an enzyme co-factor utilized in protein labeling [1].

Phospholipid-PEG-Biotin (MW 3400) is a derivative of phospholipid PEG featuring biotin and a phospholipid connected via a linear PEG linker. This compound can bind avidinylated antibodies and is used to modify liposome and cell surfaces, as well as pancreatic islets in cell transplantation applications [1] [2] [3].

Phospholipid-PEG-Biotin (MW 5000), a derivative of phospholipid PEG, serves to modify the surfaces of liposomes, cells, and pancreatic islets for cell transplantation. This compound incorporates a phospholipid (a lipid featuring a hydrophilic "head" and two hydrophobic "tails"), PEG (a hydrophilic, water-soluble polymer with low toxicity), and Biotin (an enzyme co-factor useful for protein labeling) [1].

Phospholipid-PEG-Biotin (MW 10000 and 3400) is a derivative comprising a biotin and a phospholipid connected via a linear PEG linker. This compound is capable of interacting with avidinylated antibodies and is utilized for modifying the surfaces of liposomes, cells, and pancreatic islets for cellular transplantation [1] [2] [3].

Phospholipid-PEG-Biotin (MW 20000 and MW 3400) is a derivative combining biotin and phospholipid via a linear PEG linker, capable of interacting with avidinylated antibodies. This compound facilitates the modification of liposome and cell surfaces, including pancreatic islets for cell transplantation [1] [2] [3].

Phospholipid PL1, a phospholipid-derived nanoparticle, efficiently delivers costimulatory receptor mRNA (CD137 or OX40) to T cells, thereby inducing the activation of immune cells such as T cells and dendritic cells (DCs) to enhance antitumor immunity [1].

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid utilized in liposomes for the study of lipid monolayers and bilayers.

Glycerophospholipids, cephalins (Phosphatidylethanolamines (egg)) are a mixture of phosphatidylethanolamines isolated from eggs, with various fatty acyl groups at the sn-1 and sn-2 positions. Glycerophospholipids and cephalins can be completely hydrolyzed to obtain 1 mol of glycerol, phosphoric acid, ethanolamine and 2 mol of fatty acids. Phosphatidylethanolamines play a role in membrane fusion and disassembly of contractile rings during cell division, regulating membrane curvature. Phosphatidylethanolamines are able to transmit infectious prions without the help of any proteins or nucleic acids. One of the main roles of Phosphatidylethanolamines in bacterial membranes is to disperse the negative charges caused by anionic membrane phospholipids.

SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.

S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6.

CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.

Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

AM095 (free acid) is a potent LPA1 receptor antagonist with IC50 values of 0.98 μM for recombinant human LPA1 and 0.73 μM for recombinant mouse LPA1.

Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.

Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).

CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.