pancreas

Elastase from porcine pancreas is a serine protease derived from the porcine pancreas, consisting of 240 amino acid residues. It has the ability to hydrolyze proteins and peptides, can induce emphysema in hamsters, and is commonly used to establish animal models of chronic obstructive pulmonary disease (COPD).

RNase B, Bovine Pancreas, is the N-glycosylated form of bovine pancreatic ribonuclease, structurally analogous to RNase A. It assists in polypeptide chain folding and functions similarly to a molecular chaperone.

Insulin(cattle) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients.

Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.

α-Amylase, Human Pancreas (Amylase, a-Amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase) serves as a biological material or organic compound suitable for life sciences research.

RNase A, Bovine Pancreas (Ribonuclease A) (DNase & Protease Free) is a ribonuclease and a widely used endonuclease that functions by specifically hydrolyzing cytosine or uracil residues in RNA. It is commonly employed in cell cycle analysis experiments.

Lipase, Human Pancreas (Pancreatic TriacylglycerolLipase, PL, PTL, PancreaticLipase) serves as a biological material or organic compound suitable for life science research.

Dodecylphosphocholine (DPC) is a substrate-type inhibitor of pancreas phospholipase A2. Dodecylphosphocholine is a detergent.

Pancreastatin (swine), a 49-residue peptide derived from porcine pancreas [1], significantly suppresses the release of insulin in response to glucose.

Pancreastatin (33-49), porcine, a peptide fragment derived from the porcine pancreas, exerts insulin-suppressive effects in vitro and augments the glucose priming effect [1] [2].

Pancreastatin (37-52), human, is a biologically active fragment of CgA-derived peptide (residues 250–301) that inhibits insulin release from islet beta cells [1][2].

Pancreastatin (PST), a bioactive peptide, enhances hepatic glucose output, which can contribute to diabetes.

3-arylisoquinolinamine derivative is a compound with antitumor activity.

Devazepide is a competitive, selective, orally available non-peptide CCK1 (cholecystokinin 1) receptor antagonist that inhibits bladder cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest.

Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.

CCK2 (CCK-B) receptor antagonist

AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.

Pancreatin (pancrelipase) is a mixture of several digestive enzymes secreted by the exocrine cells of the pancreas. It is composed of amylase, lipase and protease.

Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury.

Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare instances of clinically apparent acute liver injury.

Collagenase Type I is a proteolytic enzyme that primarily targets collagen and is able to break down peptide bonds in collagen. Collagenase is used as a potential therapeutic option to break up the herniated disc material, thereby reducing compression of nearby nerves. Collagenase may aid in the breakdown and reorganization of excessive scar tissue, potentially improving tissue function and appearance. Collagenase has the potential to treat intervertebral disc herniation, keloid, fat mass, lipoma, as well as Peyronie's disease and palmar fibromatosis.

Chymotrypsin (Chymotrypsin A) is a serine protease synthesized by the pancreas, which cleaves protein chains on the carboxyl side of aromatic amino acids.

Alloxan Monohydrate is a diabetogenic agent that acts as a proteasome inhibitor and induces diabetes in experimental animals by damaging the insulin-secreting β-cells in the pancreas. It is commonly used to establish diabetes models.

GRP (porcine) acetate is the gastrin-releasing peptide extracted from porcine pancreata. GRP (porcine) acetate may have a role in the parasympathetic regulation of endocrine and exocrine secretion from the pig pancreas.