nota

NOTA is a multifunctional chelator capable of forming stable complexes with metal ions and is commonly used in radiopharmaceuticals, molecular imaging and targeted nuclear therapy.

NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor and structural analogue of FAPI-4. NOTA-FAPI-4 serves as a diagnostic and therapeutic tool for diseases characterized by FAP overexpression, including its application as a positron emission tomography (PET) tracer for noninvasive imaging of FAP-associated pathological conditions and monitoring of therapeutic responses.

NOTA-bis(tBu)ester (NOTA-bis(t-Butylester)) is a derivative of NOTA and serves as a bifunctional chelator suitable for drug conjugation.

NOTA-P2-RM26 is a high-affinity NOTA-conjugated bombesin antagonist designed for GRPR-targeted tumor imaging.

Propargyl-NOTA(tBu)2 is a bifunctional chelating ligand that can bind to radionuclides to prepare radionuclide conjugates (RDCs).

p-SCN-Bn-NOTA is a stable and highly affinity integrator. It is a compound with a macrocyclic structure, consisting of two parts: SCN and Bn NOTA. Among them, SCN has the ability to chelate metal ions. This dual-functional group can simultaneously bind to metal ions and biological molecules, achieving specific biological goals.

NOTA-Pep-1L specifically targets the IL13RA2 receptor and is utilized for tumor imaging. Additionally, it is employed in the synthesis and research of radiolabeled conjugates (RDC).

NOTA-NOC is a peptide utilized in conjunction with radioactive tracers [such as Gallium-68 or Fluorine-18] for PET/CT scans, aiding in the diagnosis and monitoring of neuroendocrine tumors.

NOTA-AUNP-12 is a PD-L1 antagonist with an IC50 of 2.24×10−7 M. It shows potential for use in cancer research, particularly for conditions such as lung cancer and esophageal cancer.

NOTA-WL12 is a conjugate of WL12 (a peptide targeting PD-L1) and NOTA (a chelator). It exhibits high binding affinity to PD-L1 with a KD value of 3.012 nM. Additionally, NOTA-WL12 can be labeled with radioactive isotopes for tumor imaging.

NOTA-RHAU18 is a conjugate of the chelating agent NOTA and the peptide RHAU18. It is used for the synthesis of a radiolabeled peptide probe, [18F]AlF-NOTA-RHAU18, which targets mitochondrial (mitochondria) DNA G4. This compound enables visualization and detection of solid tumors in vivo in homozygous mice. Additionally, [18F]AlF-NOTA-RHAU18 is applicable in PET imaging studies.

p-SCN-Bn-NOTA (trihydrochloride) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used in tumor pre-targeting. It serves in the conjugation of peptides and radionuclides.

p-NH2-Bn-NOTA (hydrochloride hydrate) is a bifunctional chelator (BFC) and a macrocyclic NOTA derivative utilized for tumor pre-targeting. It can be employed for conjugation with peptides and radionuclides.

NOTA (trihydrochloride) is a bifunctional chelator (Bifunctional Chelator; BFC) and a derivative of the macrocyclic NOTA, designed for tumor pre-targeting. It facilitates the conjugation of peptides and radionuclides.

Maleimide-NOTA (TFA) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. It is suitable for conjugation with peptides and radionuclides.

(S)-P-SCN-BN-NOTA is a bifunctional chelating agent designed to covalently link the radionuclide ⁶⁴Cu with ZPDGFRβ affibody, thus creating a molecular probe [⁶⁴Cu]Cu-NOTA-ZPDGFRβ for positron emission tomography (PET) scanning.

NOTA-NHS ester is a molecule related to radiolabeled conjugates (RDC) that can be utilized in applications involving fluorescent labeling and radiolabeling.

Repinotan HCl (Bay-x-3702) is an orally active, selective and potent 5-HT1A receptor agonist across the blood-brain barrier and is an aminomethylbenzidine derivative.Repinotan HCl has potent neuroprotective effects and can be used in studies of ischemic stroke and traumatic brain injury.

Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, and hypertension.

Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury.

Cinitapride Monotartrate is a nonselective agonist of 5-HT1 and 5-HT4 receptors and an antagonist of 5-HT2 and dopamine D2 receptors, Cinitapride Monotartrate is widely applied in gastrointestinal research to investigate mechanisms underlying functional dyspepsia and gastroesophageal reflux disease, including modulation of gastrointestinal motility and visceral sensitivity.

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.

Hexamethonium monotartrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.

Acetaminotadalafil is a new analogue of Tadalafil used for the treatment of erectile dysfunction. It acts as a phosphodiesterase 5 inhibitor.