nota

NOTA is a multifunctional chelator capable of forming stable complexes with metal ions and is commonly used in radiopharmaceuticals, molecular imaging and targeted nuclear therapy.

NOTA-bis(tBu)ester (NOTA-bis(t-Butylester)) is a derivative of NOTA and serves as a bifunctional chelator suitable for drug conjugation.

NOTA-FAPI-4 is an analogue of FAPI-4 and a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI-4 is useful in the diagnosis or treatment of a disease characterized by overexpression of fibroblast activation protein (FAP). NOTA-FAPI-4 can be used as a PET tracer for detection of diseases or disorders related to fibroblast activation protein.

NOTA-P2-RM26 is a high-affinity NOTA-conjugated bombesin antagonist designed for GRPR-targeted tumor imaging.

p-SCN-Bn-NOTA is a stable and highly affinity integrator. It is a compound with a macrocyclic structure, consisting of two parts: SCN and Bn NOTA. Among them, SCN has the ability to chelate metal ions. This dual-functional group can simultaneously bind to metal ions and biological molecules, achieving specific biological goals.

Propargyl-NOTA(tBu)2 is a bifunctional chelating ligand that can bind to radionuclides to prepare radionuclide conjugates (RDCs).

Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, and hypertension.

Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury.

Repinotan HCl (Bay-x-3702) is an orally active, selective and potent 5-HT1A receptor agonist across the blood-brain barrier and is an aminomethylbenzidine derivative.Repinotan HCl has potent neuroprotective effects and can be used in studies of ischemic stroke and traumatic brain injury.

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.

Hexamethonium monotartrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.

Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases in sensory nerve conduction velocity. Melanotan II acetate increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol.

Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).

Acetaminotadalafil is a new analogue of Tadalafil used for the treatment of erectile dysfunction. It acts as a phosphodiesterase 5 inhibitor.

Melanotan I is a non-specific melanocortin receptor (MCR) agonist, an α-melanocyte-stimulating hormone (α-MSH) analog, which is injected subcutaneously to increase the amount of melanin in the skin Melanotan I is used as an adjunct to tanning Melanotan I has been used for the prevention of sunlight-induced skin cancers Melanotan I has been used in the study of melanoma and for male erectile dysfunction Melanotan I may be used to prevent sun-induced skin cancer and may be used to study melanoma and male erectile dysfunction.

NO2A-Butyne is a bifunctional chelator (Bifunctional Chelator; BFC) and a macropolycyclic NOTA derivative utilized in tumor pretargeting. It is suitable for the conjugation of peptides and radionuclides.

TCO-GK-PEG4-NHS ester serves as an ADC linker, suitable for synthesizing [18F] AlF-NOTA-Tz-TCO-GK-2Rs15d, which demonstrates high affinity and immunoreactivity to HER2 [1]. This compound is a click chemistry reagent containing a TCO group that can engage in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.