nod1

NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.

Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.

7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.

NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation.

NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor, demonstrating an IC50 value of 1.4 nM in the ADP-Glo assay. It blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathway (IC50 values are 18 nM and 170 nM for NOD1 and NOD2, respectively), thereby reducing inflammatory responses. This compound is utilized in research related to colitis.

NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.

NOD1-RIPK2-IN-1 (Compound 37) is an inhibitor of the NOD1-RIPK2 signaling pathway, displaying potent IC50 values of 42 nM and 1.52 nM against NOD1 and RIPK2, respectively. This compound effectively reduces the secretion of the pro-inflammatory cytokine IL-8, making it valuable for research in inflammation and immune disorders.

NOD1antagonist-2 (compound 66) is an orally active and selective inhibitor that can suppress NOD1 in both humans and mice. It effectively blocks the NOD1-induced NF-κB and MAPK pathways.

NOD1antagonist-1 (compound 37) acts as an antagonist to NOD1 and exhibits a slight selectivity between NOD1 and NOD2, with IC50 values of 9.18 μM and 20.8 μM, respectively.

CSLP37 is a selective RIPK2 inhibitor with an IC50 of 16.3 nM and demonstrates no inhibitory activity against RIPK1 or RIPK3. Additionally, CSLP37 effectively suppresses cellular responses mediated by NOD1 and NOD2.

FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.

TriDAP dihydrochloride (L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride) is the dihydrochloride salt form of TriDAP. It is a bioactive peptide and serves as a specific NOD1 activator.

GSK223 is an iE-DAP-stimulated IL-8 release inhibitor via the NOD1 signaling pathway.

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor that inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1]. It blocks the synergy between NOD2 and TLR2 without affecting NOD1, TNFR1, and TLR2-mediated responses. At 5 μM, GSK717 inhibits the release of IL-8, IL-6, TNFα, and IL-1β in primary human monocytes stimulated with MDP[1]. [1]. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1.

RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3. Additionally, in a 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay, RIPK2/3-IN-1 demonstrates an IC50 value of 14 ± 4 nM against RIPK2 [1].

TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid), a biologically active peptide, functions as a specific Nod1 activator.

iE-DAP is a biologically active peptide that functions as a NOD1 agonist.

M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a bioactive peptide that functions as a NOD1/2 agonist.

C12-iE-DAP (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid) is a biologically active peptide featuring a lauroyl (C12) group bonded to the glutamate residue of iE-DAP, an agonist of NOD1.

iE-DAP dihydrochloride is a Nod1 agonist that activates the NF-κB pathway through recognition by Nod1, leading to an inflammatory cytokine response. This compound is useful for studying maternal-fetal inflammation and preterm birth.

M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a bioactive peptide that functions as an agonist for NOD1/2.