nicotinamide

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Nicotinamide ascorbate is a bioactive chemical.

Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical.

Nicotinamide, N-(m-difluoromethoxyphenyl)-, hydrochloride is a bioactive chemical.

Nicotinamide Hydrochloride, a form of vitamin B3 (niacin), inhibits sirtuin 2 (SIRT2) activity in vitro with an EC50 of 2 μM, reducing melanoma cell number by up to 90% and increasing cellular NAD+, ATP, and ROS levels. It also inhibits tumor growth in vivo and improves survival in melanoma-bearing mice, making it useful for skin cancer research, including melanoma.

Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.

6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme.

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.

β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.

Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

N-(Hydroxymethyl)nicotinamide (Bilamid) is an antimicrobial agent.

Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy.

Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.

Nicotinamide riboside malate is a compound formed by the salt of nicotinamide riboside and malic acid. Nicotinamide riboside malate acts as a precursor to NAD⁺ and promotes the elevation of NAD⁺ levels within cells by supplementing the NR pathway, thereby participating in energy metabolism and the regulation of mitochondrial function.

Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.

Nicotinamide-13C6 (Standard) is a reference standard of Nicotinamide-13C6 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-13C6 is a 13C-labeled form of Nicotinamide. As a vitamin B3, Nicotinamide plays a crucial role in cellular physiology by supporting NAD+ redox homeostasis and serving as a substrate for a class of enzymes that catalyze non-redox reactions. It is also known as a SIRT1 inhibitor.

Nicotinamide-15N,13C3 (Standard) is a reference standard of Nicotinamide-15N,13C3 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-15N,13C3 is a form of nicotinamide labeled with 13C and 15N. Nicotinamide, a vitamin B3, is crucial in cellular physiology by maintaining NAD+ redox balance and supplying NAD+ as a substrate for enzymes catalyzing non-redox reactions. Nicotinamide also acts as an SIRT1 inhibitor.

Nicotinamide-D4 (Standard) is a reference standard of Nicotinamide-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.

YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.

YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effects on neurons and kidneys.

(E)-Daporinad (FK866) is a highly specific, non-competitive small molecule inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with potential anti-tumor and anti-angiogenic activities with an IC50 value of 0.09 nM.

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

Flonicamid (N-(cyanomethyl)-4-(trifluoromethyl)nicotinamide), a pyridinecarboxamide insecticide, inhibits aphid (M. persicae) salivation and sap ingestion during feeding on Japanese radish leaves. It induces toxicity in the aphid species A. gossypii, L. erysimi, R. padi, and S. graminum and rats.

TRIA-662 (Nicotinamide Chloromethylate) is a niacin metabolite excreted via the urinary system.