neuraminidase(na)

Urolithin M5 (Decarboxyellagic acid) is a neuraminidase inhibitor isolated from olive leaves with antiviral and anticancer and antitumor activities. Urolithin M5 can be used to study influenza A virus infection and SARS-CoV-2 infection.

Neuraminidase-IN-1 (Compound Y-1) is a novel neuraminidase inhibitor.

Oseltamivir phosphate (GS 4104) is a neuraminidase (NA) inhibitor with oral activity. Oseltamivir phosphate has antiviral activity and is effective against a wide range of influenza viruses, inhibiting mature influenza viruses from breaking away from host cells.

Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses.

Laninamivir (R 125489) is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).

Neuraminidase-IN-23 (33c) is a potent inhibitor of the neuraminidase enzyme (NA) targeted against influenza viruses. It exhibits inhibitory concentration (IC50) values of 0.049 μM for H1N1, 0.26 μM for H3N2, 0.17 μM for H5N1, 0.013 μM for H5N8, and 0.74 μM for H5N1-H274Y.

ent-Oseltamivir, the enantiomer of Oseltamivir, acts as an inhibitor of the influenza virus neuraminidase (NA). It holds potential for research in the study of influenza virus infections.

Oseltamivir (GS 4104) is an orally active and highly potent viral neuraminidase (NA) with antiviral activity, inhibits A H3N2, A H1N2, A H1N1 and influenza B viruses, and can be used in studies of influenza and pneumonia.

Neuraminidase-IN-6 (Compound 5c), a derivative of 1,3,4-triazole-3-acetamide, is a potent neuraminidase inhibitor with an IC50 value of 0.11 μM, making neuraminidase (NA) an ideal target for anti-influenza drug development [1].

Neuraminidase-IN-5 (Compound 5b), a dihydrofurocoumarin derivative, acts as a potent neuraminidase (NA) inhibitor, exhibiting significant inhibition with an IC 50 of 0.02 μM. Given NA's role in influenza pathogenesis, this compound emerges as a promising candidate for anti-influenza drug development [1].

Influenza virus-IN-4 (compound 11e) is a potent inhibitor of influenza virus neuraminidase, effective against H5N1 (IC50: 3.4 μM), H5N2 (IC50: 0.094 μM), H5N6 (IC50: 0.79 μM), and H5N8 (IC50: 0.077 μM). It inhibits NA (neuraminidase) and exhibits low cytotoxicity (CC50 > 200 μM), and is not significantly toxic to mice at 1500 mg kg.

Neuraminidase-IN-4 (Compound 4b) is a potent inhibitor of neuraminidase (EC50: 1.59 μM) and exhibits significant antiviral activity against A chicken Hubei 327 2004 (H5N1-DW).

Influenza virus-IN-3 (compound 9) is a potent inhibitor of selective influenza viruses, with IC50 values of 0.88 μM for H5N1, 0.10 μM for H5N2, 5.5 μM for H5N6, and 0.51 μM for H5N8. Influenza virus-IN-3 exhibits antiviral and NA (neuraminidase) inhibitory effects with low cytotoxicity (CC50 > 200 μM).

Neuraminidase-IN-3 (compound 23d) is a potent inhibitor of influenza neuraminidase (NA) with IC50 values of 0.73 nM for H1N1, 0.26 nM for H5N1, and 0.63 nM for H5N8 NAs.

Neuraminidase-IN-11 (15e) is a selective and potent neuraminidase (NA) inhibitor, effective against the neuraminidase of H1N1 virus (IC50: 4.7 nM), H5N1 virus (IC50: 8.46 nM), and H5N8 virus (IC50: 1.5 nM).

DS-22-inf-021, a neuraminidase (NA) inhibitor, exhibits antiviral activity against influenza viruses [1].

Neuraminidase-IN-18 (compound N5), a novel polyheterocyclic neuraminidase (NA) inhibitor, demonstrates significant inhibitory activity against H5N1 NA, with an IC 50 of 0.14 μM against the wild-type H5N1 NA and 0.27 μM against the H5N1-H274Y mutant NA. This compound effectively binds to NAs, inhibiting influenza virus replication at the cellular level [1].

Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity.

Oseltamivir-d3 is a deuterated compound of Oseltamivir. Oseltamivir has a CAS number of 196618-13-0. Oseltamivir (GS 4104) is an orally active and highly potent viral neuraminidase (NA) with antiviral activity, inhibits A H3N2, A H1N2, A H1N1 and influenza B viruses, and can be used in studies of influenza and pneumonia.

The binding affinities of ganoderic acid DM andGanoderic acid ζ (ΔGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.

Dehydrocorybulbine chloride is an isoquinoline alkaloid with neuraminidase (NA) inhibitory activity. It can be isolated from the 95% ethanol extract of the roots and rhizomes of Corydalis.