n106

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

EN106, a potent FEM1B inhibitor and a cysteine-reactive covalent ligand, effectively disrupts the recognition of FEM1B's crucial reductive stress substrate, FNIP1.

Memogain is a pro-drug of galantamine. It is used for the treatment of Alzheimer's disease.

SARS-CoV-2-IN-106 (compound 19) is a SARS-CoV-2 papain-like protease inhibitor, displaying IC50 values of 0.44 μM for papain-like proteases and 0.18 μM for viral replication.

EGFR-IN-106 (compound 6) is a potent inhibitor of EGFR, with an IC50 value of 0.2396 µM. It also exhibits cytotoxic and anti-inflammatory properties.

Aclimostat (ZGN-1061) is a highly potent inhibitor of the MetAP2 enzyme, demonstrating promising efficacy and safety profiles in preclinical trials. In a mouse model of obesity and insulin resistance, ZGN-1061 shows comparable weight loss efficacy to beloranib and improves metabolic parameters. Additionally, ZGN-1061 induces consistent changes in gene transcription in HepG2 cells, further supporting its positive pharmacological effects.

Cefonicid (free base) is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

TX-1123 is a potent inhibitor of protein tyrosine kinase (PTK), specifically targeting Src, eEF2-K, PKA, and EGFR-K/PKC. Additionally, it acts as a cyclo-oxygenase (COX) inhibitor, displaying IC50 values of 1.16 μM for COX2 and 15.7 μM for COX1, indicating a higher affinity towards COX2. With low mitochondrial toxicity, TX-1123 is beneficial for cancer research applications.

MEN-10627 is a polycyclic peptide and tachykinin NK2 receptor antagonist.

MEN-10612 is a cyclic pseudopeptide and potent tachykinin NK-2 receptor antagonist.

WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

Coumarin 478 is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 10.7 and 27.8 µ M, respectively.

Prion peptide fragment that exhibits neurotoxicity