modest

Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.

Ilexoside O, a triterpene saponin derived from Ilex pubescens roots, demonstrates modest inhibition of xanthine oxidase (XOD) activity with an IC50 value of 53.05 μM.

Harzianum A, a trichothecene isolated from the soil-borne fungus Trichoderma harzianum, exhibits no cytotoxicity against baby hamster kidney cells and lacks activity against both Gram-negative and Gram-positive bacteria. However, it demonstrates modest antifungal activity at a concentration of 100 μg mL [1].

11-Oxomogroside II A1 (compound 7), an oxidized cucurbitin derived from the ethanol extract of Rohanberry fruit, inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and modestly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor [1].

Aloveroside A, a triglucosylnaphthalene derivative extracted from Aloe vera using ethanol, exhibits modest inhibitory activity against bACE, demonstrating approximately 18.68% inhibition at a concentration of 100 μg mL [1].

Compound 11, labeled as a weak Hepatoprotective agent-1, is a naturally occurring substance extracted from the fruits of Arctium lappa L. It demonstrates modest hepatoprotective effects when applied at a concentration of 10 μM [1].

1,1′-Disinomenine, an alkaloid extracted from the stems of Sinomenium acutum, exhibits modest inhibitory activity against A549 and Hela cells [1].

Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-κB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM.

Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity.

Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg mL, respectively.

Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg mL, while showing only modest cytotoxicity.

Pinocembrin 7-O-[4 ,6 -(S)-HHDP]-β-D-glucoside (compound 3) is a polyphenol that exhibits modest antiproliferative activity in PDGF-induced HSC-T6 cells, with an IC50 of 200 μM.