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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11696 | Ivachtin | Caspase-3 Inhibitor VII | Caspase |
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. | |||
T68351 | Homodestcardin | ||
Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells. | |||
TQ0101 | MKC3946 | IRE1 | |
MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. | |||
T6139 | A-674563 | A674563 | ERK , GSK-3 , Akt , PKA , CDK |
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. | |||
T12338 | OXFBD04 | Epigenetic Reader Domain | |
OXFBD04 is a potent and selective BRD4 inhibitor (IC50= 166 nM). OXFBD04 is a potent BET bromodomain ligand and exhibits additional modest affinity for the CREBBP bromodomain. OXFBD04 exhibits anti-cancer activity. | |||
T6139L | A-674563 2HCl(552325-73-2(fb-2hcl)) | ERK , Akt , PKA , CDK , PKC | |
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. | |||
T11381 | Pictilisib dimethanesulfonate | GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt | Apoptosis , DNA-PK , PI3K , mTOR , Autophagy |
Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). | |||
T2329 | Dolutegravir sodium | GSK1349572,GSK-1349572A | HIV Protease |
Dolutegravir sodium (GSK-1349572A) salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | |||
T68095 | Losulazine | Dopamine Receptor , Norepinephrine | |
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-b... | |||
T11143 | EB-47 | PARP | |
EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC... | |||
T6865 | Quisinostat dihydrochloride | Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl | Apoptosis , HDAC , Autophagy |
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g... | |||
T6419 | BMS-536924 | HY-10262,BMS 536924,CS-0117 | Apoptosis , FAK , MEK , IGF-1R , Src |
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. | |||
T6055 | Quisinostat | JNJ-26481585 | Apoptosis , HDAC , Autophagy |
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... | |||
T3465 | Vesnarinone | OPC-8212,Arkin,Piteranometozine | HIV Protease , PDE |
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel... | |||
T68405 | KW-2450 free base | IGF-1R | |
KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.KW-2450 free base shows modest growth inhibitory activity and inhibits IGF-1-induced signaling in a mouse HT-29/GFP colo... | |||
T15781 | LP-935509 | Serine/threonin kinase , AAK1 (AP2 associated kinase 1) | |
LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-... | |||
TQ0291 | Firategrast | SB 683699 | Integrin |
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity... | |||
T32458 | L 653328 | L 653,328,L653328,L653,328,L-653,328,L-653328 | |
L 653328 is an ocular hypotensive agent that has modest beta-receptor blocking activity. | |||
T28163 | NEU-730 | ||
NEU-730, a novel inhibitor of TbrPDEB1, shows modest inhibition of T. brucei proliferation. | |||
TN4835 | Przewalskin | HIV Protease | |
Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively. |