mitf

Methyl Linoleate (Telfairic Acid methyl ester) linoleate has antioxidant activity.

Trans-caffeic acid (3,4-Dihydroxybenzeneacrylic acid) can be used as a highly sensitive fluorescent probe for the detection of laccase in food and can also stimulate the growth of germ tissue.

Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and microphthalmia-associated transcription factor (MITF). This inhibition ultimately leads to a decrease in melanin synthesis.

Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 signaling and blocking the NF-κB and MAPK signaling pathways and inhibits melanin biosynthesis by down-regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis-related proteins through modulation of MITF activity, which promotes phosphorylation of p38 and JNK in melan-a cells.

6-Acetylnimbandiol (6-O-Acetylnimbandiol), a non-cytotoxic tyrosinase inhibitor (IC 50 = 69.85 μM), effectively inhibits melanin production and MITF expression, making it valuable for melanoma research [1].

N,N′-Diferuloylputrescine acts as a pigment inhibitor, showing a 57% reduction in pigmentation. It also considerably diminishes the protein expression of MITF and displays potent antioxidant properties as a radical scavenger against reactive oxygen species [1].

Ganodermanondiol is a natural melanogenesis inhibitor capable of suppressing tyrosinase, TRP-1, TRP-2, and MITF in B16F10 cells, while influencing MAPK and cAMP pathways. It also exhibits anti-inflammatory and hepatoprotective effects by modulating Nrf2-dependent HO-1 and AMPK.

Swertiajaponin possesses antimicrobial activity.

Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of tyrosinase and TRP-1 production. Hag

(-)-Lyoniresinol 9'-O-glucoside is a natural product derived from Phyllostachys heterocycla [MITF].

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act