mid-1

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake

Sulfacetamid-13C6 (Standard) is a reference standard of Sulfacetamid-13C6 intended for quantitative analysis, quality control, and related biochemical research applications.

Famiraprinium is a competitive antagonist at the GABA receptor site.

Ethambutol-d10 is the deuterated form of Ethambutol. Ethambutol acts as an antimycobacterial agent by inhibiting the activity of arabinosyl transferase, thereby preventing the formation of the bacterial cell wall.

Liraglutide-13C6,15N (TFA) is a version of Liraglutide labeled with 13C and 15N. Liraglutide acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and is clinically used for the treatment of type 2 diabetes.

4-Hydroxynonenal-d3 is the deuterated form of 4-Hydroxynonenal (4-HNE), an α,β-unsaturated hydroxyalkenal and a biomarker of oxidative/nitrosative stress. This compound acts as both a substrate and inhibitor of ALDH2. It modulates numerous signaling pathways primarily through covalent adduct formation with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. Additionally, 4-Hydroxynonenalal plays a significant role in cancer through mitochondrial interactions.

6-Mercaptopurine-13C2,15N is a 6-Mercaptopurine labeled with 13C and 15N. This compound is a purine analog that acts as an antagonist to endogenous purines and is widely used for its anti-leukemic and immunosuppressive properties.

PNU-100766-d8 is a deuterium-labeled form of Linezolid. Linezolid (PNU-100766) is the first member of the oxazolidinone class of synthetic antibiotics, functioning by inhibiting the initiation of bacterial protein synthesis, thereby exhibiting anti-infective properties.

Sodium (S)-2-hydroxypropanoate-d3 is the deuterated form of Sodium (S)-2-hydroxypropanoate.

Nepsilon-acetyl-L-lysine-d8 is the deuterated form of Nepsilon-acetyl-L-lysine, a derivative of the amino acid lysine.

Arachidonic acid-d11 is the deuterated form of Arachidonic acid, an essential fatty acid and a key component of biological membranes.

Oleic acid-13C18 is the 13C-labeled version of oleic acid. Oleic acid (9-cis-Octadecenoic acid) is the most prevalent monounsaturated fatty acid found in human adipose tissue and other tissues. It acts as an activator of the Na+/K+ATPase enzyme.

Propofol-d18 is the deuterated form of Propofol. Propofol effectively activates GABA_A receptors directly and inhibits excitatory synaptic transmission mediated by glutamate receptors.

Adenosine-13C is the 13C-labeled form of Adenosine. Adenosine (Adenine riboside) is a widely occurring endogenous secretion that operates through four G protein-coupled receptors (A1, A2A, A2B, and A3). It influences nearly every aspect of cell physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70 is the deuterated form of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. The compound 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a lipid that is utilized in the synthesis of liposomes and is part of the lipid nanoparticle (LNP) system.

Sulfanilamide-d4 is the deuterated form of Sulfanilamide. Sulfanilamide acts as an inhibitor of the bacterial enzyme dihydropteroate synthase, with an IC50 of 320 μM.

Thymidine-5'-monophosphate-13C10,15N2 (disodium) is the thymidine-5'-monophosphate disodium salt labeled with isotopes 13C and 15N. It is an endogenous metabolic compound.

Carfilzomib-d8 is the deuterated form of Carfilzomib. Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.

Bedaquiline impurity 2-d6 is a deuterated form of Bedaquiline. Bedaquiline (TMC207) is a diarlyquinoline active compound that inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase by targeting both the c-subunit and ε-subunit simultaneously. It exhibits uncoupling activity and has potential use for multidrug-resistant tuberculosis.

Tucidinostat-d4 is the deuterated form of Tucidinostat. Tucidinostat is an effective, orally bioavailable inhibitor of HDAC class I HDAC1/2/3 and class IIb HDAC10, with IC50 values of 95, 160, 67, and 78 nM, respectively.

L-Threonine-13C4 is an isotopically labeled form of L-Threonine (13C). L-Threonine, a naturally occurring amino acid produced through microbial fermentation, finds applications in food, pharmaceuticals, and animal feed.

N-Lactoyl-Phenylalanine-13C6 (Lac-Phe-13C6) is the 13C-labeled form of N-Lactoyl-Phenylalanine, a blood-derived signaling metabolite that can be induced by exercise. This compound has been shown to reduce obesity and improve glucose tolerance.

Olaparib-d4-1 (AZD2281-d4-1) is a deuterated form of Olaparib. Olaparib is an orally active PARP inhibitor, with IC50 values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Additionally, Olaparib acts as an activator of autophagy and mitophagy.

L-Ascorbic acid-13C-4 is 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate) functions as an electron donor and acts as an endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. Additionally, L-Ascorbic acid promotes collagen deposition and inhibits elastin formation.