manifestations

Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. D-Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

Lumasiran (ALN-G01) is a small interfering RNA therapeutic that targets hepatic glycolate oxidase mRNA, silences enzyme expression, reduces oxalate biosynthesis. Lumasiran addresses the pathogenic metabolic defect underlying primary hyperoxaluria type 1, supporting its use in translational and mechanistic disease research.

Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).