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Search Results for " malignancies "

Targets

160

Compounds

7

Natural Products

179

Recombinant Proteins

4

Libraries

Cat No. Product Name Synonyms Targets
T12367 Parsaclisib INCB050465 PI3K
Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
T12317 Orelabrutinib ICP-022 BTK
Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).
T6055 Quisinostat JNJ-26481585 Apoptosis , HDAC , Autophagy
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against...
T6761 Ossirene AS101 IL Receptor , Caspase , Interleukin
Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
T12477 Uzansertib phosphate INCB053914 phosphate Pim
Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).
T22349 JNJ-38158471 CS-2660 VEGFR , c-RET , c-Kit
JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.
T12311 Tirabrutinib hydrochloride ONO-4059 (hydrochloride),GS-4059 (hydrochloride) BTK
Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) is a selective and novelBTK with IC50 2.2 nm inhibitor.
T4976 Umbralisib TGR-1202,RP5264,TGR 1202,TGR1202 PI3K
Umbralisib (TGR 1202) is a PI3Kδ inhibitor.
T0975 Chlorambucil CB-1348,Chloroambucil,WR-139013 DNA Alkylator/Crosslinker , DNA Alkylation
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...
T1038 Fludarabine NSC 118218,Fludarabinum,F-ara-A Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , STAT
Fludarabine (Fludarabinum) is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T6079 NVP-ADW742 ADW742,ADW,GSK 552602A Apoptosis , IGF-1R
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
T12574 PTC299 Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate VEGFR , Dehydrogenase
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at t...
T6104 Cerdulatinib hydrochloride Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19...
T6865 Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl Apoptosis , HDAC , Autophagy
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g...
T28297 Parsaclisib hydrochloride Parsaclisib HCl,INCB-50465,INCB 050465,INCB-050465,INCB050465 HCl,INCB 50465,INCB50465 HCl PI3K
Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
T10436 AZD4573 CDK
AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.
T1601 Lomustine CCNU,NSC 79037 Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T23903 CM037 CM-037,A-37,CM 037,A37,A 37 Dehydrogenase
CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminate gynecologic malignancies.
TNU0014 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil Apoptosis
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analog with a broad spectrum of antitumor activity targeting inert lymphoid malignancies and inducing apoptosis.1-(2-Deoxy-2-fluoro-beta-D-arabino...
T9756 AZD-9574 PARP
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
T1962 ASP3026 ASP 3026 Apoptosis , ALK
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.
T7221 Satraplatin BMS182751,JM216,BMY45594 DNA Alkylator/Crosslinker , DNA Alkylation
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
TNU0352 1-beta-D-Arabinofuranosylthymine Thymine 1-β-D-arabinofuranoside,Spongothymidine Apoptosis
1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing ...
T3069 AZD-1480 JAK
AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...
T76705 Utomilumab PF 05082566,PF-2566 TNF
Utomilumab (PF 05082566) is a humanized IgG2 antibody targeting the T-cell co-stimulatory receptor 4-1BB/CD137 and a 4-1BB/CD137 agonist.Utomilumab has antitumor activity and may be used in the study of patients with adv...
T63788 PCLX-001 Others
PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstra...
T17028 Tefinostat CHR-2845 HDAC
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefino...
T4428 CCT241736 FLT , Aurora Kinase
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica...
T68316 GAC0003A4 GAC0001E5 Liver X Receptor
GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits the proliferation of PDAC cells in a dose-dependent manner.G...
TQ0236 Tirabrutinib ONO-4059,GS-4059,Velexbru BTK
Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and ...
T3626 Acalabrutinib ACP-196 BTK
Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre...
T38960 QL-X-138 Virus Protease , MNK , BTK
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, MNK1 and MNK2 kinases are 9.4 nM, 107.4 nM and 26 nM, respe...
T19661 8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258 AMPK
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...
T36083 DS-7423 PI3K , mTOR
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...
T36944 Ara-G Nucleoside Antimetabolite/Analog
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate...
T20858 Metanilic acid m-Anilinesulfonic acid,m-Sulfanilic acid
Metanilic acid, an anti-cancer drug, is used to treat several malignancies including choriocarcinoma and pediatric acute lymphoblastic leukemia.
T27274 EP009
EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.
T27558 HT1042 HT 1042,HT-1042
HT1042 is an inhibitor of the β5i component of the 20S proteasome complex, it is used to aid in the treatment of inflammatory diseases, autoimmune and hematologic malignancies.
T11603 Ibrutinib-MPEA Others
Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.
T11544 HDACs/mTOR Inhibitor 1 HDAC
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα).
T68411 AT-7519M
AT-7519M is a small molecule inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies.
T70759 CUDC-907 mesylate
CUDC-907 mesylate is a small molecule inhibitor of histone deacetylase and PI3 kinase developed by Curis. It is investigated in clinical trials for the treatment of relapsed or refractory lymphomas, thyroid cancer, multi...
T21329 Gemcitabine monophosphate disodium salt Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP
R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.
T2610 BMS-599626 AC480 EGFR , MEK , HER , Src
BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T22859 Imatinib hydrochloride Others
Imatinib is a multi-target inhibitor of v-Abl, c-Kit, and PDGFR (IC50: 0.6 μM, 0.1 μM, and 0.1 μM, respectively). Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs), and...
T79067 PROTAC BTK Degrader-3 PROTACs
PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells. This compound shows promise for research into B-cell malignanci...
T62896 EZH2-IN-12
EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.
T63497 PI3Kδ/γ-IN-1
PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.
T79840 Bocodepsin hydrochloride OKI-179 hydrochloride HDAC
Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration. It is employed in the suppression of both solid tumors and hematological malignancies [1].
T76929 Betifisolimab
Betifisolimab (MSB-2311) is a humanized monoclonal antibody directed against the immunosuppressive ligand PD-L1 . Betifisolimab has the potential for advanced solid tumors and hematological malignancies research [1] .

Compounds

Parsaclisib
T12367
Synonym: INCB050465
Target: PI3K
Orelabrutinib
T12317
Synonym: ICP-022
Target: BTK
Quisinostat
T6055
Synonym: JNJ-26481585
Target: Apoptosis, HDAC, Autophagy
Ossirene
T6761
Synonym: AS101
Target: IL Receptor, Caspase, Interleukin
Uzansertib phosphate
T12477
Synonym: INCB053914 phosphate
Target: Pim
JNJ-38158471
T22349
Synonym: CS-2660
Target: VEGFR, c-RET, c-Kit
Tirabrutinib hydrochloride
T12311
Synonym: ONO-4059 (hydrochloride),GS-4059 (hydrochloride)
Target: BTK
Umbralisib
T4976
Synonym: TGR-1202,RP5264,TGR 1202,TGR1202
Target: PI3K
Chlorambucil
T0975
Synonym: CB-1348,Chloroambucil,WR-139013
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Fludarabine
T1038
Synonym: NSC 118218,Fludarabinum,F-ara-A
Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, STAT
NVP-ADW742
T6079
Synonym: ADW742,ADW,GSK 552602A
Target: Apoptosis, IGF-1R
PTC299
T12574
Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Target: VEGFR, Dehydrogenase
Cerdulatinib hydrochloride
T6104
Synonym: Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride
Target: MLK, c-Fms, Tyrosine Kinases, Hippo pathway, JAK, Syk
Quisinostat dihydrochloride
T6865
Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl
Target: Apoptosis, HDAC, Autophagy
Parsaclisib hydrochloride
T28297
Synonym: Parsaclisib HCl,INCB-50465,INCB 050465,INCB-050465,INCB050465 HCl,INCB 50465,INCB50465 HCl
Target: PI3K
AZD4573
T10436
Synonym:
Target: CDK
Lomustine
T1601
Synonym: CCNU,NSC 79037
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy
CM037
T23903
Synonym: CM-037,A-37,CM 037,A37,A 37
Target: Dehydrogenase
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
TNU0014
Synonym:
Target: Apoptosis
AZD-9574
T9756
Synonym:
Target: PARP
ASP3026
T1962
Synonym: ASP 3026
Target: Apoptosis, ALK
Satraplatin
T7221
Synonym: BMS182751,JM216,BMY45594
Target: DNA Alkylator/Crosslinker, DNA Alkylation
1-beta-D-Arabinofuranosylthymine
TNU0352
Synonym: Thymine 1-β-D-arabinofuranoside,Spongothymidine
Target: Apoptosis
AZD-1480
T3069
Synonym:
Target: JAK
Utomilumab
T76705
Synonym: PF 05082566,PF-2566
Target: TNF
PCLX-001
T63788
Synonym:
Target: Others
Tefinostat
T17028
Synonym: CHR-2845
Target: HDAC
CCT241736
T4428
Synonym:
Target: FLT, Aurora Kinase
GAC0003A4
T68316
Synonym: GAC0001E5
Target: Liver X Receptor
Tirabrutinib
TQ0236
Synonym: ONO-4059,GS-4059,Velexbru
Target: BTK
Acalabrutinib
T3626
Synonym: ACP-196
Target: BTK
QL-X-138
T38960
Synonym:
Target: Virus Protease, MNK, BTK
8-Chloroadenosine
T19661
Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258
Target: AMPK
DS-7423
T36083
Synonym:
Target: PI3K, mTOR
Ara-G
T36944
Synonym:
Target: Nucleoside Antimetabolite/Analog
Metanilic acid
T20858
Synonym: m-Anilinesulfonic acid,m-Sulfanilic acid
Target:
EP009
T27274
Synonym:
Target:
HT1042
T27558
Synonym: HT 1042,HT-1042
Target:
Ibrutinib-MPEA
T11603
Synonym:
Target: Others
HDACs/mTOR Inhibitor 1
T11544
Synonym:
Target: HDAC
AT-7519M
T68411
Synonym:
Target:
CUDC-907 mesylate
T70759
Synonym:
Target:
Gemcitabine monophosphate disodium salt
T21329
Synonym: Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP
Target:
BMS-599626
T2610
Synonym: AC480
Target: EGFR, MEK, HER, Src
Imatinib hydrochloride
T22859
Synonym:
Target: Others
PROTAC BTK Degrader-3
T79067
Synonym:
Target: PROTACs
EZH2-IN-12
T62896
Synonym:
Target:
PI3Kδ/γ-IN-1
T63497
Synonym:
Target:
Bocodepsin hydrochloride
T79840
Synonym: OKI-179 hydrochloride
Target: HDAC
Betifisolimab
T76929
Synonym:
Target:
1 2 3 4
Cat No. Product Name Synonyms Targets
T9715 Aplidine SARS-CoV , DNA/RNA Synthesis
Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).
TNU0052 Nebularine 9-(beta-D-Ribofuranosyl)-9H-purine Apoptosis
Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.The anticancer mechanism of Nebulari...
T3380 Homoharringtonine Myelostat,Ceflatonin,HHT,Omacetaxine mepesuccinate STAT
Homoharringtonine (HHT) is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome. Homoharringtonine enhances the ...
T35000 Uproleselan sodium GMI 1271,GMI1271,GMI-1271
Uproleselan sodium (GGI-1271) is a small molecule E-selector antagonist originally targeted at AML as an adjuvant to standard chemotherapy for hematological malignancies.
T12403 Penitrem A Others
Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
TN2299 Vindesine Others
Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms.
T16035 Meleagrin Others
Meleagrin is a class of FabI inhibitors. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies. Meleagrin is a roquefortine C-derived alkaloid p...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01257 UPAR/PLAUR Protein, Mouse, Recombinant (His) Mouse HEK293
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and ...
TMPY-04289 CD30L Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPY-00705 CD30L Protein, Human, Recombinant (hFc) Human HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPY-02141 UPAR/PLAUR Protein, Human, Recombinant (His) Human HEK293
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and ...
TMPY-05446 CD200 Protein, Human, Recombinant (hFc) Human HEK293
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-06842 BMP-4 Protein, Human, Recombinant (E399D) Human E. coli
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPY-00970 CD31/PECAM-1 Protein, Human, Recombinant (His) Human HEK293
The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transm...
TMPY-01896 HGFR/c-Met Protein, Mouse, Recombinant (His) Mouse HEK293
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-00548 HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-01296 HGFR/c-Met Protein, Human, Recombinant (His) Human HEK293
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-01827 CD30/TNFRSF8 Protein, Human, Recombinant (His) Human HEK293
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-02030 CD82 Protein, Human, Recombinant (His) Human HEK293
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras...
TMPY-02566 Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 an...
TMPY-01423 OX40/TNFRSF4 Protein, Human, Recombinant (His) Human HEK293
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a rea...
TMPY-01068 CD70 Protein, Human, Recombinant (hFc) Human HEK293
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, diff...
TMPY-04803 DLL4 Protein, Human, Recombinant Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-01321 DLL4 Protein, Human, Recombinant (His) Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-01337 DLL4 Protein, Mouse, Recombinant (His) Mouse HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-00776 DLL4 Protein, Human, Recombinant (hFc) Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-05094 Tissue Factor Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02530 Tissue Factor Protein, Human, Recombinant (His) Human HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-03644 CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-03776 CD25/IL2R alpha Protein, Cynomolgus, Recombinant Cynomolgus HEK293
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-05644 CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated Rhesus HEK293
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-01923 CD25/IL2R alpha Protein, Mouse, Recombinant (His) Mouse HEK293
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-03713 GM-CSF/CSF2 Protein, Rat, Recombinant (His) Rat HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-05090 CD25/IL2R alpha Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-01103 CD25/IL2R alpha Protein, Human, Recombinant (His) Human HEK293
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-05584 CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated ...
TMPY-00750 GM-CSF/CSF2 Protein, Human, Recombinant (hFc) Human HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03662 GM-CSF/CSF2 Protein, Mouse, Recombinant (His) Mouse HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03858 GM-CSF/CSF2 Protein, Human, Recombinant Human HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-04114 GM-CSF/CSF2 Protein, Mouse, Recombinant Mouse HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPK-00008 CCL5 Protein, Mouse, Recombinant (hFc) Mouse HEK293
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited n...
TMPK-00618 FcRH5/FcRL5 Protein, Human, Recombinant (His) Human HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPK-01039 FcRH5/FcRL5 Protein, Mouse, Recombinant (His) Mouse HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPK-00009 CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated Human E. coli
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited n...
TMPK-00619 FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPK-01145 FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPK-00800 CDH3 Protein, Mouse, Recombinant (His) Mouse HEK293
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPK-01306 CDH3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPK-00851 CDH3 Protein, Human, Recombinant (aa 108-654, His) Human HEK293
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPY-03748 BCL2L12 Protein, Human, Recombinant (GST) Human E. coli
BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the predicti...
TMPK-00270 TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled Human HEK293
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR...
TMPK-00271 TPBG/5T4 Protein, Human, Recombinant (His & Avi) Human HEK293
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR...
TMPY-03239 CD30L Protein, Rat, Recombinant (hFc) Rat HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPY-03582 CD30L Protein, Rat, Recombinant Rat HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPY-04581 CD30L Protein, Human, Recombinant Human HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPK-00812 Midkine Protein, Mouse, Recombinant (His) Mouse E. coli
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue hom...
TMPY-03001 CD52 Protein, Rat, Recombinant (hFc) Rat HEK293
CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view t...
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uPAR/PLAUR Protein, Mouse, Recombinant (His)
TMPY-01257
Species: Mouse
Expression System: HEK293
CD30L Protein, Cynomolgus, Recombinant (His)
TMPY-04289
Species: Cynomolgus
Expression System: HEK293
CD30L Protein, Human, Recombinant (hFc)
TMPY-00705
Species: Human
Expression System: HEK293
uPAR/PLAUR Protein, Human, Recombinant (His)
TMPY-02141
Species: Human
Expression System: HEK293
CD200 Protein, Human, Recombinant (hFc)
TMPY-05446
Species: Human
Expression System: HEK293
BMP-4 Protein, Human, Recombinant (E399D)
TMPY-06842
Species: Human
Expression System: E. coli
CD31/PECAM-1 Protein, Human, Recombinant (His)
TMPY-00970
Species: Human
Expression System: HEK293
HGFR/c-Met Protein, Mouse, Recombinant (His)
TMPY-01896
Species: Mouse
Expression System: HEK293
HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-00548
Species: Cynomolgus,Rhesus
Expression System: HEK293
HGFR/c-Met Protein, Human, Recombinant (His)
TMPY-01296
Species: Human
Expression System: HEK293
CD30/TNFRSF8 Protein, Human, Recombinant (His)
TMPY-01827
Species: Human
Expression System: HEK293
CD82 Protein, Human, Recombinant (His)
TMPY-02030
Species: Human
Expression System: HEK293
Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His)
TMPY-02566
Species: Human
Expression System: Baculovirus-Insect Cells
OX40/TNFRSF4 Protein, Human, Recombinant (His)
TMPY-01423
Species: Human
Expression System: HEK293
CD70 Protein, Human, Recombinant (hFc)
TMPY-01068
Species: Human
Expression System: HEK293
DLL4 Protein, Human, Recombinant
TMPY-04803
Species: Human
Expression System: HEK293
DLL4 Protein, Human, Recombinant (His)
TMPY-01321
Species: Human
Expression System: HEK293
DLL4 Protein, Mouse, Recombinant (His)
TMPY-01337
Species: Mouse
Expression System: HEK293
DLL4 Protein, Human, Recombinant (hFc)
TMPY-00776
Species: Human
Expression System: HEK293
Tissue Factor Protein, Cynomolgus, Recombinant (His)
TMPY-05094
Species: Cynomolgus
Expression System: HEK293
Tissue Factor Protein, Human, Recombinant (His)
TMPY-02530
Species: Human
Expression System: HEK293
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His)
TMPY-03644
Species: Cynomolgus
Expression System: HEK293
CD25/IL2R alpha Protein, Cynomolgus, Recombinant
TMPY-03776
Species: Cynomolgus
Expression System: HEK293
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated
TMPY-05644
Species: Rhesus
Expression System: HEK293
CD25/IL2R alpha Protein, Mouse, Recombinant (His)
TMPY-01923
Species: Mouse
Expression System: HEK293
GM-CSF/CSF2 Protein, Rat, Recombinant (His)
TMPY-03713
Species: Rat
Expression System: HEK293
CD25/IL2R alpha Protein, Rat, Recombinant (His)
TMPY-05090
Species: Rat
Expression System: Baculovirus-Insect Cells
CD25/IL2R alpha Protein, Human, Recombinant (His)
TMPY-01103
Species: Human
Expression System: HEK293
CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-05584
Species: Human
Expression System: HEK293
GM-CSF/CSF2 Protein, Human, Recombinant (hFc)
TMPY-00750
Species: Human
Expression System: HEK293
GM-CSF/CSF2 Protein, Mouse, Recombinant (His)
TMPY-03662
Species: Mouse
Expression System: HEK293
GM-CSF/CSF2 Protein, Human, Recombinant
TMPY-03858
Species: Human
Expression System: HEK293
GM-CSF/CSF2 Protein, Mouse, Recombinant
TMPY-04114
Species: Mouse
Expression System: HEK293
CCL5 Protein, Mouse, Recombinant (hFc)
TMPK-00008
Species: Mouse
Expression System: HEK293
FcRH5/FcRL5 Protein, Human, Recombinant (His)
TMPK-00618
Species: Human
Expression System: HEK293
FcRH5/FcRL5 Protein, Mouse, Recombinant (His)
TMPK-01039
Species: Mouse
Expression System: HEK293
CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00009
Species: Human
Expression System: E. coli
FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00619
Species: Human
Expression System: HEK293
FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01145
Species: Human
Expression System: HEK293
CDH3 Protein, Mouse, Recombinant (His)
TMPK-00800
Species: Mouse
Expression System: HEK293
CDH3 Protein, Cynomolgus, Recombinant (His)
TMPK-01306
Species: Cynomolgus
Expression System: HEK293
CDH3 Protein, Human, Recombinant (aa 108-654, His)
TMPK-00851
Species: Human
Expression System: HEK293
BCL2L12 Protein, Human, Recombinant (GST)
TMPY-03748
Species: Human
Expression System: E. coli
TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled
TMPK-00270
Species: Human
Expression System: HEK293
TPBG/5T4 Protein, Human, Recombinant (His & Avi)
TMPK-00271
Species: Human
Expression System: HEK293
CD30L Protein, Rat, Recombinant (hFc)
TMPY-03239
Species: Rat
Expression System: HEK293
CD30L Protein, Rat, Recombinant
TMPY-03582
Species: Rat
Expression System: HEK293
CD30L Protein, Human, Recombinant
TMPY-04581
Species: Human
Expression System: HEK293
Midkine Protein, Mouse, Recombinant (His)
TMPK-00812
Species: Mouse
Expression System: E. coli
CD52 Protein, Rat, Recombinant (hFc)
TMPY-03001
Species: Rat
Expression System: HEK293
Cat No. Product Name
L8400 Hematonosis Compound Library

524 compounds
A unique collection of 524 compounds related to hematologic diseases for high throughput screening (HTS) and high content screening (HCS);
L2194 Anti-Colorectal Cancer Compound Library

1565 compounds
1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L4300 Wnt/Hedgehog/Notch Compound Library

240 compounds
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L6740 Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library

386 compounds
A collection of 386 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies.
TargetMol