m40

Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

AM4085 is an orally effective FmlH antagonist with an IC50 of 0.19 μM. It demonstrates stability in both mouse liver microsomes and plasma.

AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.

CAM4066 is a novel potent and selective CK2alpha inhibitor.

Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12. Q-VD-OPh inhibits HIV infection and can cross the blood-brain barrier.

CORM-401 is an oxidant-sensitive CO-releasing molecule used in the research of oxidative stress-mediated pathologies and inflammation [inflammatory].

MM-401 is a specific inhibitor of histone H3K4 methyltransferase MLL1 activity that acts by reprogramming mouse epiblast stem cells to naive pluripotency.

Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.

VM4-037 is a PET imaging agent used for carbonic anhydrase IX.

VM4-037 F-18 is a fluorinated PET imaging agent used for carbonic anhydrase IX.

Lartesertib (ATM Inhibitor-5) is an inhibitor of serine/threonine protein kinase ATM with potential anticancer activity for the study of lung cancer.

Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.

Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.

Imisopasem manganese (M40403) is a manganese superoxide dismutase (MnSOD) non-peptidyl mimetic.

MM-401 (TFA), an MLL1 H3K4 methyltransferase inhibitor, effectively impedes MLL1 activity (IC 50 = 0.32 µM) by preventing MLL1-WDR5 interaction. It can induce cell cycle arrest, apoptosis, and differentiation, offering potential for MLL leukemia research [1].

Porustobart is a monoclonal antibody that targets and inhibits CTLA4.

3β-Cholic Acid (Standard) is a reference standard of 3β-Cholic Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Deoxycholic Acid 3-O-β-D-Glucuronide Disodium Salt (Standard) is a reference standard of Deoxycholic Acid 3-O-β-D-Glucuronide Disodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

3-Oxodeoxycholic Acid (Standard) is a reference standard of 3-Oxodeoxycholic Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Tauro-ω-Muricholic Acid Sodium Salt (Standard) is a reference standard of Tauro-ω-Muricholic Acid Sodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

4-CHOLENIC ACID-3-ONE (Standard) is a reference standard of 4-CHOLENIC ACID-3-ONE intended for quantitative analysis, quality control, and related biochemical research applications.

7α-Hydroxy-3-oxochol-4-en-24-oic Acid-[13C3] in Methanol (Standard) is a reference standard of 7α-Hydroxy-3-oxochol-4-en-24-oic Acid-[13C3] in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

L-3,3`-Diiodothyronine (T2) (Standard) is a reference standard of L-3,3`-Diiodothyronine (T2) intended for quantitative analysis, quality control, and related biochemical research applications.