less active enantiomer

Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer.

Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Duvelisib.

(-)-Camphoric acid (L-Camphoric acid) is a less active enantiomer of Camphoric acid which induces GluR expression.

(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. Isolated from hyssop oil, it possesses antifungal, highly active whitening, and antioxidant properties, and it has potential applications in cosmeceutical materials. It downregulates proinflammatory cytokines in vitro and in vivo, reduces the number of total cells, neutrophils, and macrophages in BALF, attenuates histologic lung alterations, decreases the wet-to-dry weight ratio in BALF, and inhibits the activation of NF-kappa-B inhibitor alpha, extracellular regulated protein kinases, c-JunN-terminal kinase, and p38 mitogen-activated protein kinase.

(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties.

ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.

SAR405 (R enantiomer) is the less active form of SAR405, an inhibitor of PIK3C3 Vps34.

Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.

ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100, an activator of the stimulator of interferon genes (STING).

Bay 65-1942 (R form) is the less active enantiomer of Bay 65-1942, a selective and ATP-competitive IKKβ inhibitor.

(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).

Cobimetinib R-enantiomer, the less active R-enantiomer of Cobimetinib, is a selective MEK inhibitor.

Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.

Fulvestrant R enantiomer is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.

Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.

l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine.

Firsocostat S enantiomer is the less active S enantiomer of Firsocostat.

PD-1-IN-20 [476690-36-9] is the less active enantiomer of PD-1-IN-1 [1346528-06-1].

(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501, a selective and potent Human Neutrophil Elastase (HNE) inhibitor with an IC50 of 65 pM.

(R)-MIK665, the less active enantiomer of MIK665, is a specific inhibitor of Mcl-1 with an IC50 of 1.81 nM.

(R)-Nicardipine is the less active R enantiomer of Nicardipine. Nicardipine is a blocker of calcium channel(IC50 of 1 μM for blocking cardiac calcium channels).

(R)-Plevitrexed is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).

(R)-(+)-Anatabine, the less active R-enantiomer of Anatabine, is a potent agonist of α4β2 nAChR.

(R)-SCH 42495, the less active enantiomer of SCH 42495, is an orally active inhibitor of neutral metalloendopeptidase (NEP) with antihypertensive effects.