kv1.5 channel

BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome.

BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.

Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research.

MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization that is associated with atrial-specific ultra-rapid K+ current I Kur.

(R)-MK-0448 is an isomer of MK-0448.MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization that is associated with atrial-specific ultra-rapid K+ current I Kur.

DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels

KVI-020 is a selective, orally active blocker of the atrial potassium channel Kv1.5 (IC50: 480 nM). kVI-020 exhibits inhibition of hERG (IC50: 15100 nM). KVI-020 is a potent antiarrhythmic agent and can be used in the study of atrial fibrillation (AF).

S9947 is a Kv1.5 IKur channel blocker, suppressing both cloned (Kv1.5) and native (IKur) cardiac potassium current.

Mephetyl tetrazole is a potassium channel (Kv1.5) blocker with an IC50 value of 330 nM. It is applicable in cancer research.

DDO-02001 can be used in anti-arrhythmia research. DDO-02001 is a moderately potent inhibitor of Kv1.5 potassium channel with an IC50 value of 17.7 μM [1].

DDO-02005 is a potent inhibitor of the Kv1.5 calcium channel (IC50: 0.72 μM).DDO-02005 exhibits good anti-fibrillation effects in a CaCl2-ACh atrial fibrillation rat model and is effective against anti-aconitine-induced arrhythmias.

Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.

DDO-02005 (free base), a potent Kv1.5 potassium channel inhibitor, demonstrates an IC 50 of 0.72 μM. It exhibits effective anti-atrial fibrillation (AF) properties in the CaCl2-ACh AF rat model and anti-arrhythmic activity against aconitine-induced arrhythmias [1].