irf1-in-2

IRF1-IN-2 (Compound I-19) is an inhibitor of IRF1. It reduces the recruitment of IRF1 to the CASP1 promoter and hinders cell death signaling pathways by inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1, as well as by preventing the phosphorylation of TKB1. The compound also upregulates GPX4 and downregulates FACL4. Additionally, IRF1-IN-2 provides protective effects against skin inflammatory damage induced by ionizing radiation.

IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor that reduces IRF1 recruitment to the CASP1 promoter. It inhibits cell death signaling pathways by preventing the cleavage of Caspase 1, GSDMD, IL-1, and PARP1. Additionally, IRF1-IN-1 has a protective effect against ionizing radiation-induced skin inflammation.