indications — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9683	VX-150		Sodium Channel
	VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).		Sodium Channel
T60351	Acetazolamide sodium	OT-302 sodium	Carbonic Anhydrase
	Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and alt...		Carbonic Anhydrase
T5444	CLP290	CLP-290	Potassium Channel
	CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.		Potassium Channel
T2270	Trans-Tranilast	Tranilast trans-	RAAS
	Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993....		RAAS
T1012	Acebutolol hydrochloride	Acebutolol HCl	Adrenergic Receptor
	Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydro...		Adrenergic Receptor
T23936	D-4418
	D-4418 is a PDE4 inhibitor. It has been in development as a novel anti-inflammatory therapy with asthma and chronic obstructive pulmonary disease being primary indications.
T68557	PF-376304
	PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.
T21324	R306465	R-306465,JNJ 16241199,R 306465,JNJ-16241199,JNJ16241199
	R306465 is a potent inhibitor of HDAC1 and -8 (class I) in vitro. It potently inhibited cell proliferation of all main solid tumour indications, including colon, ovarian, breast, lung and prostate cancer cell lines with ...
T70393	PF-303
	PF-303 is a covalent-reversible BTK inhibitor. Inhibitors of Bruton's tyrosine kinase (BTK) possess much promise for the treatment of oncologic and autoimmune indications.
T71624	GB1874
	GB1874 inhibitor of the Wnt pathway that targets the β-cat-TCF4 PPI. GB1874 also affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro. Encouragingly, GB1874 inhibited the growth...
T61820	Ar-V7-IN-1
	Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indication...
T27568	IACS-010759 hydrochloride	IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759
	IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NA...
T37905	Hexanoyl Glycine
	Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. I...
T14614	Biperiden Hydrochloride	KL 373 (Hydrochloride)	Others
	Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker and it is used for the adjunctive treatment of all forms of Parkinson's disease (pos...		Others
T14359	AVX 13616		Others
	AVX 13616, Avexa's leading antibacterial candidate, demonstrates significant in vivo antibacterial efficacy, especially against drug-resistant Staphylococcus pathogens, with an IC50 value of 2-4 µg/ml (MICs) and is targe...		Others