h89

H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a selective inhibitor of cAMP-dependent protein kinase A (PKA) with an IC50 value of 48 nM. It also mildly inhibits PKG, PKC, and casein kinase activity. H-89 dihydrochloride can be used in research areas such as cell proliferation, apoptosis, metabolism, neurotransmission, and endocrine regulation.

ZH8965 is an orally active TAAR1-Gs/Gq agonist (EC50: 6.1/14.8 nM) that shows efficacy in alleviating antipsychotic-like phenotypes and cognitive deficits in an MK-801-induced psychosis model in mice. It is applicable for research related to schizophrenia.

H-89 is a selective and potent protein kinase A inhibitor (IC50: 48 nM), a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.

Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).