fc-11

FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation.

BFC1108 targets Bcl-2 and converts it to a pro-apoptotic protein, inhibits the growth of triple-negative breast cancer xenografts with high Bcl-2 expression, inhibits breast cancer lung metastasis, and induces apoptosis of Bcl-2-expressing cancer cells.

Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.

Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).

Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome by blocking caspase-1 activation and thus preventing the activation of IL-1β/IL-18. Additionally, Fc 11a-2 inhibits the progression of Dextran sulfate sodium (DSS)-induced murine experimental colitis [1] [2] [3].

Argtide is an luteinizing hormone releasing hormone (LHRH) antagonist.

FC11409B is a CAIX inhibitor, inhibiting breast cancer invasion and metastasis.

BFC1103 is a small molecule compound that primarily interacts with a specific domain of Bcl-2, particularly its loop domain. This interaction causes a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homologous 3) domain and switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of either Bax or Bak, both of which are crucial proteins in the mitochondrial-mediated intrinsic apoptosis pathway. In mouse models, BFC1103 effectively inhibited lung metastasis of triple-negative breast cancer. BFC1103 can be used to study the role of Bcl-2 family proteins in cancer development and their impact on cancer cell survival and proliferation.