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Cat No. | Product Name | Synonyms | Targets |
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T8796 | CAN508 | CDK | |
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50... | |||
T15771 | Lobaplatin | D-19466 | DNA Alkylation |
Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ... | |||
T2455 | PFK-015 | PFK15,PFK 015 | Glucokinase , Autophagy |
PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM). | |||
T7322 | Theliatinib | EGFR | |
Theliatinib, a potent and highly selective EGFR inhibitor, with anti-tumor activity. Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively. | |||
T0992 | Carbenoxolone disodium | Biogastrone,Duogastrone,Bioral | Gap Junction Protein |
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ... | |||
T0866 | Propafenone | Rythmol,Propafenonum | Potassium Channel , MRP , Sodium Channel |
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.... | |||
T11918 | Lysipressin | Lysine vasopressin,[Lys8]-Vasopressin | Others |
Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. | |||
T0044 | Oxethazaine | Oxetacaine | HBV , Sodium Channel |
Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain. | |||
T6136 | Canertinib | PD-183805,CI-1033 | EGFR |
Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp... | |||
T39640 | JAB-3068 | SHP2-IN-6 | Phosphatase |
JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor with anticancer and antitumor activity for the study of breast, lung, and esophageal cancers. | |||
T8341 | QX 314 | QX-314 | Others |
QX 314 (Lidocaine N-ethyl bromide) is a blocker of non-membrane-permeable,and Inhibits Acid-Induced Activation of Esophageal Nociceptive C Fiber Neurons. | |||
T24610 | Pegamotecan | Prothecan,PEG-camptothecin,PEG-beta-CPT | Topoisomerase |
Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung and pancreatic cancers. | |||
T76717 | Serplulimab | HLX 10 | COX |
Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal squamous cell carcinoma. | |||
T38387 | Compound C108 | GTPase | |
Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma. | |||
T61699 | Osunprotafib | AC 484,Osunprotafib,AC484,ABBV-CLS-484 | Phosphatase |
ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cance... | |||
T35394 | Sintilimab (anti-PD-1) | IBI308,Sintilimab (anti-PD-1) | PD-1/PD-L1 |
Sintilimab (IBI308) is a humanized IgG4 monoclonal antibody with significant anti-tumor activity that restores endogenous anti-tumor T-cell responses by binding to PD-1 and thereby blocking the interaction of PD-1 with i... | |||
T1291 | Cisapride | Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase | Potassium Channel , 5-HT Receptor , HER |
Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease... | |||
T9636 | Dalpiciclib | SHR-6390 | CDK |
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag... | |||
T71399 | Plogosertib | CYC140 | |
Plogosertib (CYC140), a selective and potent orally active ATP-competitive PLK1 inhibitor (IC 50: 3 nM), functions as an anticancer agent with antiproliferative effects. It is utilized in the research of various tumors s... | |||
T7057 | Methylstat | Histone Demethylase , Others | |
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD... | |||
T33471 | Monoethanolamine Oleate | FO-611,Ethamolin,brand name: Ethamolin,FO 611,FO611 | |
Monoethanolamine Oleate (Etamolin, FO-611) is a hardening agent used in the treatment of varicose and esophageal veins. | |||
T1552L | Itopride free base | HSR803,HSR-803,Itopride hydrochloride,HSR 803 | |
Itopride HCl is an AChE inhibitor and dopamine D2 receptor antagonist. It inhibits lower esophageal sphincter relaxation. It also used to treat functional dyspepsia and gastroesophageal reflux disease | |||
T80599 | Dectrekumab | QAX576 | |
Dectrekumab (QAX576), a humanized monoclonal antibody targeting IL-13, significantly reduces intraepithelial esophageal eosinophil counts and normalizes dysregulated esophageal disease-related transcripts in Eosinophilic... | |||
T11691 | IV-23 | Others | |
IV-23, a potent inhibitor of cell growth both in vitro and in vivo, effectively reduces colony formation, arrests the cell cycle at the M phase, and induces apoptosis in esophageal squamous cell carcinoma through Noxa-me... | |||
T74997 | ERK-IN-6 | ||
ERK-IN-6 (compound 6g) serves as a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC), inducing apoptosis through the ERK pathway. This compound has potential applications in ESCC research ... | |||
T36709 | N’-Nitrosonornicotine | ||
N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. ... | |||
T63199 | Dalpiciclib hydrochloride | ||
Dalpiciclib (SHR-6390) hydrochloride is a highly selective, orally active CDK4/6 inhibitor with IC50 values of 12.4 nM and 9.9 nM, respectively, and is capable of acting as an antitumor agent in breast and esophageal squ... | |||
T40572 | Lesogaberan napadisylate | AZD-3355 napadisylate | |
Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B recepto... | |||
T35822 | CAY10722 | ||
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functio... | |||
T35616 | Migrastatin | ||
Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectiv... | |||
T76997 | Socazolimab | ||
Socazolimab (ZKAB001), an anti-PD-L1 monoclonal antibody, demonstrates enduring safety and efficacy in treating recurrent or metastatic cervical cancer. Additionally, it shows promise for treating small cell lung cancer,... | |||
T64075 | Afatinib oxalate | ||
Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) that acts on EGFRwt (IC50: 0.5 nM), EGFRL858R (IC50: 0.4 nM), EGFRL858R/T790M ( IC50: 10 nM) and HER2... | |||
T72215 | Lesogaberan hydrochloride | AZD-3355 hydrochloride | |
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and ... | |||
T36714 | Sucrose octasulfate (potassium salt) | ||
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium agains... | |||
T72912 | (R)-Afatinib | (R)-BIBW 2992 | |
(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S1844 | Tenacissoside H | Tenacissimoside C | Others |
Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade. | |||
T4S1796 | Heterophyllin B | PI3K | |
Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa... | |||
TN1721 | Gypenoside L | ERK , p38 MAPK , Calcium Channel , NF-κB , ROS | |
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... | |||
T2836 | Isorhamnetin | 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin | MEK , PI3K , Endogenous Metabolite |
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD... | |||
T75569 | Xerophilusin B | ||
Xerophilusin B, isolated from Isodon xerophilus as an anticancer agent, demonstrates antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines. It induces G2/M cell cycle arrest and mediates apopt... | |||
TN4166 | Griffipavixanthone | ERK , Raf , ROS , MEK , Caspase | |
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS productio... | |||
T36448 | (E)-Ajoene | ||
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fu... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01174 | DKK1 Protein, Rhesus, Recombinant (N256Q, His) | Rhesus | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-00775 | DKK1 Protein, Human, Recombinant (His) | Human | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-04811 | DKK1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-01897 | PRSS3 Protein, Human, Recombinant (His) | Human | HEK293 |
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains on... | |||
TMPY-02062 | SULT1A1 Protein, Human, Recombinant (His) | Human | E. coli |
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroid... | |||
TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d... | |||
TMPY-06984 | EGF Protein, Mouse, Recombinant (Yeast) | Mouse | Yeast |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-01062 | EGF Protein, Human, Recombinant (hFc) | Human | HEK293 |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-01560 | EGF Protein, Human, Recombinant | Human | E. coli |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPH-02681 | GPX7 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. | |||
TMPK-01076 | GPA34/VSIG1 Protein, Human, Recombinant (His) | Human | HEK293 |
VSIG1, a cell adhesion protein of the immunoglobulin superfamily, is preferentially expressed in stomach, testis, and certain gastric, esophageal and ovarian cancers. Here, we describe the expression patterns of three al... | |||
TMPK-01160 | GPA34/VSIG1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
VSIG1, a cell adhesion protein of the immunoglobulin superfamily, is preferentially expressed in stomach, testis, and certain gastric, esophageal and ovarian cancers. Here, we describe the expression patterns of three al... | |||
TMPJ-00703 | Gankyrin Protein, Human, Recombinant | Human | E. coli |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblast... | |||
TMPJ-01372 | Cornulin Protein, Human, Recombinant (His) | Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter... | |||
TMPY-01175 | DKK1 Protein, Rhesus, Recombinant (N256Q, mFc) | Rhesus | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-05479 | DKK1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-05797 | DKK1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-03459 | CRIP2 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth mus... | |||
TMPY-03342 | CRIP2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth mus... | |||
TMPY-02796 | KIAA0101 Protein, Human, Recombinant (His) | Human | E. coli |
KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA bind... | |||
TMPY-02129 | Transglutaminase 3/TGM3 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina... | |||
TMPY-02372 | Peroxiredoxin 1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is... | |||
TMPY-01276 | Peroxiredoxin 1 Protein, Human, Recombinant (His) | Human | E. coli |
Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is... | |||
TMPY-01204 | SMYD2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, ... | |||
TMPY-02267 | EGF Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-00220 | EGF Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-04884 | EGF Protein, Canine, Recombinant | Canine | Yeast |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-06493 | EGF Protein, Feline, Recombinant (hFc) | Feline | HEK293 |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-04220 | EGF Protein, Rat, Recombinant | Rat | E. coli |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-02539 | EGF Protein, Canine, Recombinant (His) | Canine | E. coli |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-03701 | EGF Protein, Mouse, Recombinant | Mouse | HEK293 |
EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ... | |||
TMPY-02228 | P53 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and... |