enveloped

Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against enveloped and non-enveloped viruses, suppressing virus propagation and modulating the expression of inflammatory cytokines for use as an anti-influenza virus agent [3]. It effectively inhibits the fusion of the virus with host cells [1] [2] and is an efficient inhibitor of SARS-CoV-2 in vitro [2].

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. It inhibits the entry of enveloped viruses from several families, including Coronaviridae (SARS-CoV-1, SARS-CoV-2, MERS-CoV), Filoviridae (EBOV, MARV), and Paramyxoviridae (NiV, HeV), as well as the glycosylated non-enveloped rotavirus. SCR005 binds to viral envelope N-glycans, blocking the virus from attaching to host cells or disrupting both attachment and membrane fusion. It demonstrates a preventive effect in hACE2 mice infected with SARS-CoV-2. SCR005 is applicable for the study and prevention of enveloped viral pandemics.

SCR007 is a synthetic carbohydrate receptor (SCR) known for its broad-spectrum antiviral activity. It inhibits the entry of enveloped viruses across several families, including coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV), filoviruses (EBOV, MARV), and paramyxoviruses (NiV, HeV), as well as glycosylated non-enveloped rotaviruses. SCR007 targets the N-glycans on virus envelopes, blocking viral attachment to host cells or hindering both attachment and membrane fusion. It exhibits preventive effects in hACE2 mice infected with SARS-CoV-2 and can be employed for research and prevention of pandemics caused by enveloped viruses.

IHVR-11029 is a potent inhibitor of ER α-glucosidase. IHVR-11029 is active against multiple hemorrhagic fever viruses and efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses.

LJ-001 shows broad-spectrum activity against virtually all enveloped RNA and DNA viruses. LJ001 inhibits the infection of transmissible gastroenteritis virus (TGEV) and porcine delta coronavirus (PDCoV).

F8-S43-S3 is a highly effective entry inhibitor targeting enveloped viruses. It exhibits significant in vitro neutralizing activity against various influenza strains by binding to specific viral surface glycoproteins and interfering with the membrane fusion process.

Pradimicin A (PRM-A) is a compound with potent antifungal capabilities, demonstrating a minimum inhibitory concentration (MIC) of 4 μg/mL against Candida rugosa. It also exhibits antiviral activity against viruses such as CoV, HIV, and other enveloped viruses. Additionally, Pradimicin A possesses the ability to aggregate and specifically recognize d-Man in the presence of Ca2+ ions [1] [2].

SARS-CoV-2-IN-25 (Compound CP026) is a potent inhibitor of SARS-CoV-2 spike pseudoparticle transduction, with an inhibitory concentration (IC50) of 1.6 μM. It effectively inhibits both enveloped viruses and liposomes [1].

SARS-CoV-2-IN-25 (Compound CP026) disodium, a potent inhibitor of SARS-CoV-2 spike pseudoparticle transduction, demonstrates significant efficacy with an IC50 value of 1.6 μM. It also effectively inhibits enveloped viruses and liposomes, highlighting its broad-spectrum antiviral potential.

Human α-defensin 5 is an antiviral peptide that inhibits the infection of non-enveloped viruses such as AdV, HPV, and polyomaviruses, with an IC50 range of 0.6-1.25 μM specifically for HPV16. It functions by binding to the viral capsid and preventing viral escape from the endosome. Additionally, Human α-defensin 5 enhances HIV attachment to the cell surface and exhibits parasiticidal activity [1].

Antiviralagent 58 (Compound J1) is an orally active antiviral agent that exhibits broad-spectrum activity against enveloped viruses. It effectively targets various pathogens, including Influenza A virus (IAV), Respiratory Syncytial Virus (RSV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Human Coronavirus OC43 (HCoV-OC43), and Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2).

Monocaprin is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.

Arbidol-D6 hydrochloride is a deuterated compound of Arbidol Hydrochloride. Arbidol Hydrochloride (T0104) has a CAS number of 131707-23-8. Arbidol (Umifenovir) hydrochloride, an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.

Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. It exhibits inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi, and enveloped viruses. Tachyplesin-3 disrupts membrane integrity by binding to bacterial membrane lipopolysaccharides through its positive charge, leading to leakage of cellular contents. It also interferes with bacterial adhesion and aggregation, preventing biofilm formation, and shows a synergistic effect when used in combination with Piperacillin-Tazobactam (TZP).