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Results for "

destabilizing

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    19
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
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    TargetMol | Peptide_Products
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    4
    TargetMol | Recombinant_Protein
Fosbretabulin Disodium
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, Combretastatin A4 Phosphate, Combretastatin A4 disodium phosphate, CA 4P, CA 4DP
T6272168555-66-6
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.
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Microtubule destabilizing agent-2
T203045
Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective anticancer compound targeting microtubule proteins. It disrupts microtubule stability, inhibiting microtubule polymerization. This agent causes human tumor cells to arrest in the G0 G1 phase and induces apoptosis (Apoptosis) through activation of the Caspase cascade pathway. Additionally, it exhibits anti-inflammatory properties, inhibiting the production of TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 also suppresses tumor growth in xenograft mice.
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Microtubule destabilizing agent-1
T741662850370-28-2
Compound 12b (Microtubule Destabilizing Agent-1), a hydroxamic acid-based microtubule destabilizing agent (MDA), exhibits potent antitumor activity, favorable metabolic stability, and high bioavailability, making it a promising candidate for further investigation as an MDA [1].
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Vincristine sulfate
Leurocristine sulfate, Leurocristine, 22-Oxovincaleukoblastine sulfate
T12702068-78-2
Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.
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Siramesine
Lu 28-179
T4620147817-50-3
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost
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1-2 weeks
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CHM-1
T22661154554-41-3
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
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6-8 weeks
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TargetMol | Inhibitor Sale
Tubulysin B
T13937205304-87-6
Tubulysin B is an agent of potent microtubule destabilizing and highly cytotoxic peptide isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis.
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Tubulysin
T139451943604-24-7
Tubulysin family are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, and are potent microtubule destabilizing agents.
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Siramesine hydrochloride
Lu 28-179 hydrochloride
T1885224177-60-0
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.
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Shield-2
T247881013621-70-9
Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
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6-8 weeks
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cmp3a
CMP-3a, CMP 3a
T270522225902-88-3
CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase E
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8-10 weeks
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IMC-76
NSC-59276,IMC 76,NSC 59276,NSC59276
T3214798129-27-2
IMC-76 is a BCL2 i-motif-interactive compound that can act by destabilizing or unfolding the i-motif.
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6-8 weeks
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Podoverine A
T34102107882-43-9
Podoverine A is a microtubule destabilizing natural product from the Podophyllum species.
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Vincristine
T3S020957-22-7
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hematologic cancers, such as leukemia and
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4-6 weeks
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DAP-81
T68686794466-17-4
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
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6-8 weeks
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PC-046
T712521202401-59-9
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4 SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with distribution to both plasma and bone marrow. No myelosuppression was seen in non-tumor bearing SCID mice given a single dose just under the acute lethal dose. The COMPARE algorithm in the NCI-60 cell line panel demonstrated that PC-046 closely correlated to other known tubulin destabilizing agents (correlation coefficients ≈0.7 for vincristine and vinblastine). Mechanism of action studies showed cell cycle arrest in metaphase and inhibition of tubulin polymerization. Overall, these studi......
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6-8 weeks
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Antiproliferative agent-23
T74844
Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein, upregulation of Bax and Cyt c proteins, and activation of the caspase cascade. Additionally, it induces reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549 CDDP cells (cisplatin-resistant cancer cell line) through the PERK ATF4 CHOP signaling pathway, demonstrating anti-tumor activity [1].
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Thanatin acetate
Thanatin acetate(214542-43-5 Free base)
T80999L
Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting the growth of bacteria and fungi by targeting the LptC-LptA interaction and destabilizing the LptA complex involved in lipopolysaccharide transport.
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Taccabulin A
TN78671464719-37-6
Taccabulin A, a new retro-dihydrochalcone, with microtubule-destabilizing activity has been identified from the roots and rhizomes of Tacca species.
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